ID Q04IK2_STRP2 Unreviewed; 427 AA.
AC Q04IK2;
DT 14-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 14-NOV-2006, sequence version 1.
DT 29-MAY-2013, entry version 51.
DE RecName: Full=UDP-N-acetylglucosamine 1-carboxyvinyltransferase;
DE EC=2.5.1.7;
DE AltName: Full=Enoylpyruvate transferase;
DE AltName: Full=UDP-N-acetylglucosamine enolpyruvyl transferase;
GN Name=murA-2; Synonyms=murA; OrderedLocusNames=SPD_1764;
OS Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=373153;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D39 / NCTC 7466;
RX PubMed=17041037; DOI=10.1128/JB.01148-06;
RA Lanie J.A., Ng W.L., Kazmierczak K.M., Andrzejewski T.M.,
RA Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Winkler M.E.;
RT "Genome sequence of Avery's virulent serotype 2 strain D39 of
RT Streptococcus pneumoniae and comparison with that of unencapsulated
RT laboratory strain R6.";
RL J. Bacteriol. 189:38-51(2007).
CC -!- FUNCTION: Cell wall formation. Adds enolpyruvyl to UDP-N-
CC acetylglucosamine (By similarity).
CC -!- CATALYTIC ACTIVITY: Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-
CC glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-
CC D-glucosamine.
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the EPSP synthase family. MurA subfamily.
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DR EMBL; CP000410; ABJ55139.1; -; Genomic_DNA.
DR RefSeq; YP_817186.1; NC_008533.1.
DR ProteinModelPortal; Q04IK2; -.
DR SMR; Q04IK2; 1-422.
DR STRING; 373153.SPD_1764; -.
DR EnsemblBacteria; ABJ55139; ABJ55139; SPD_1764.
DR GeneID; 4442163; -.
DR KEGG; spd:SPD_1764; -.
DR PATRIC; 19684836; VBIStrPne27904_1928.
DR eggNOG; COG0766; -.
DR HOGENOM; HOG000075602; -.
DR KO; K00790; -.
DR OMA; SIWALAP; -.
DR ProtClustDB; PRK09369; -.
DR BioCyc; SPNE373153:GIX6-1764-MONOMER; -.
DR UniPathway; UPA00219; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008760; F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity; IEA:HAMAP.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:HAMAP.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR GO; GO:0019277; P:UDP-N-acetylgalactosamine biosynthetic process; IEA:InterPro.
DR Gene3D; 3.65.10.10; -; 2.
DR HAMAP; MF_00111; MurA; 1; -.
DR InterPro; IPR001986; Enolpyruvate_Tfrase_dom.
DR InterPro; IPR013792; RNA3'P_cycl/enolpyr_Trfase_a/b.
DR InterPro; IPR005750; UDP_GlcNAc_COvinyl_MurA.
DR PANTHER; PTHR21090:SF4; PTHR21090:SF4; 1.
DR Pfam; PF00275; EPSP_synthase; 1.
DR SUPFAM; SSF55205; RNA3'_cycl/enolpyr_transf_A/B; 1.
DR TIGRFAMs; TIGR01072; murA; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cell shape;
KW Cell wall biogenesis/degradation; Complete proteome; Cytoplasm;
KW Peptidoglycan synthesis; Transferase.
FT ACT_SITE 120 120 Proton donor (By similarity).
FT MOD_RES 120 120 2-(S-cysteinyl)pyruvic acid O-
FT phosphothioketal (By similarity).
SQ SEQUENCE 427 AA; 45895 MW; F0E341DAA5489C2E CRC64;
MDKIVVQGGD NRLVGSVTIE GAKNAVLPLL AATILASEGK TVLQNVPILS DVFIMNQVVG
GLNAKVDFDE EAHLVKVDAT GDITEEAPYK YVSKMRASIV VLGPILARVG HAKVSMPGGC
TIGSRPIDLH LKGLEAMGVK ISQTAGYIEA KAERLHGAHI YMDFPSVGAT QNLMMAATLA
DGVTVIENAA REPEIVDLAI LLNEMGAKVK GAGTETITIT GVEKLHGTTH NVVQDRIEAG
TFMVAAAMTG GDVLIRDAVW EHNRPLIAKL LEMGVEVIEE DEGIRVRSQL ENLKAVHVKT
LPHPGFPTDM QAQFTALMTV AKGESTMVET VFENRFQHLE EMRRMGLHSE IIRDTARIVG
GQPLQGAEVL STDLRASAAL ILTGLVAQGE TVVGKLVHLD RGYYGFHEKL AQLGAKIQRI
EANDEDE
//
