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Database: UniProt/TrEMBL
Entry: Q08CM2_DANRE
LinkDB: Q08CM2_DANRE
Original site: Q08CM2_DANRE 
ID   Q08CM2_DANRE            Unreviewed;       566 AA.
AC   Q08CM2;
DT   31-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2006, sequence version 1.
DT   24-JAN-2024, entry version 79.
DE   SubName: Full=GPI transamidase component PIG-S {ECO:0000313|RefSeq:NP_001070082.1};
DE   SubName: Full=Zgc:152927 {ECO:0000313|EMBL:AAI24179.1};
GN   Name=zgc:152927 {ECO:0000313|EMBL:AAI24179.1,
GN   ECO:0000313|RefSeq:NP_001070082.1};
GN   OrderedLocusNames=pigs {ECO:0000313|RefSeq:NP_001070082.1,
GN   ECO:0000313|ZFIN:ZDB-GENE-060929-436};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI24179.1};
RN   [1] {ECO:0000313|EMBL:AAI24179.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Whole body {ECO:0000313|EMBL:AAI24179.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|RefSeq:NP_001070082.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=22915831;
RA   Ahn D., You K.H., Kim C.H.;
RT   "Evolution of the tbx6/16 subfamily genes in vertebrates: insights from
RT   zebrafish.";
RL   Mol. Biol. Evol. 29:3959-3983(2012).
RN   [3] {ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23594743; DOI=10.1038/nature12111;
RG   Genome Reference Consortium Zebrafish;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA   Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA   Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA   Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA   Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA   Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA   Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA   Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA   Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA   Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA   Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA   Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA   Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA   Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA   Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA   Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA   Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA   Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA   Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA   Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA   Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA   Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [4] {ECO:0000313|RefSeq:NP_001070082.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26469318;
RA   Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA   Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA   Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA   Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA   Reith W., Hertzano R.;
RT   "RFX transcription factors are essential for hearing in mice.";
RL   Nat. Commun. 6:8549-8549(2015).
RN   [5] {ECO:0000313|RefSeq:NP_001070082.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=27189481;
RA   Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA   Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA   Bobe J.;
RT   "Gene evolution and gene expression after whole genome duplication in fish:
RT   the PhyloFish database.";
RL   BMC Genomics 17:368-368(2016).
RN   [6] {ECO:0000313|RefSeq:NP_001070082.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=28252024;
RA   Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA   Choudhary J.S., Emes R.D., Grant S.G.;
RT   "Evolution of complexity in the zebrafish synapse proteome.";
RL   Nat. Commun. 8:14613-14613(2017).
RN   [7] {ECO:0000313|RefSeq:NP_001070082.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC       biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the PIGS family.
CC       {ECO:0000256|ARBA:ARBA00005316}.
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DR   EMBL; BC124178; AAI24179.1; -; mRNA.
DR   RefSeq; NP_001070082.1; NM_001076614.1.
DR   GeneID; 767675; -.
DR   KEGG; dre:767675; -.
DR   CTD; 94005; -.
DR   ZFIN; ZDB-GENE-060929-436; pigs.
DR   OrthoDB; 5476244at2759; -.
DR   PhylomeDB; Q08CM2; -.
DR   UniPathway; UPA00196; -.
DR   Proteomes; UP000000437; Chromosome 21.
DR   GO; GO:0042765; C:GPI-anchor transamidase complex; IBA:GO_Central.
DR   GO; GO:0016255; P:attachment of GPI anchor to protein; IBA:GO_Central.
DR   InterPro; IPR019540; PtdIno-glycan_biosynth_class_S.
DR   PANTHER; PTHR21072; GPI TRANSAMIDASE COMPONENT PIG-S; 1.
DR   PANTHER; PTHR21072:SF13; GPI TRANSAMIDASE COMPONENT PIG-S; 1.
DR   Pfam; PF10510; PIG-S; 1.
PE   1: Evidence at protein level;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:Q08CM2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        18..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        529..551
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   566 AA;  62903 MW;  AF81414EF1D45939 CRC64;
     MLLKIVLLGI TEKQRGRYAA LAIAAVVIIV GIPLWWKTTE TYRAWLPFSD INELDSLQLR
     LSVDIEVVFS RGTLTPEQQK KIPLSHVNEK EHQVDAKTGL RYQYETRYRT ATVMEEDALN
     QPTAAEADLS LHTLTESSCG SVVVYVIPES SVLLPEDVKV YVGQRRTALL RSPPFKSSWS
     LNEVISNLNP RVEQIASTMS FSHQDITAAL SDRVRMTKVT KESMADSMRA IKSSPGYEIT
     FSLLNPDPKS HSLHWDIEGA LHSYIQPLLN KLAPIANFSV DSQILYYAVL GVNPRFDNSV
     SAYTLNADSL SHVINPVEAR LGSNAASSNP VLNFLLYVPD AHHSPLFIRD HSRREVPTNA
     FHSPRWGGIM VYNVNDLYGP ESERPVDISI NMAKVMGVFL AQLRLMLGVH QTHPPSGFVL
     QSPGSAGLAD WELDRLMWSR SVENIATAST TITSLAQLLD QIGNIVINDN IALQVSSAVT
     SLQAAVAELD AGNLVFALQY SREAILASER AFFDPSLLHL LYFPDDQKFA IYIPLFLPMC
     VPIVLSLLKI VSEVKKRRAE KQAKSD
//
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