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Database: UniProt/TrEMBL
Entry: Q0A9L5_ALKEH
LinkDB: Q0A9L5_ALKEH
Original site: Q0A9L5_ALKEH 
ID   Q0A9L5_ALKEH            Unreviewed;       744 AA.
AC   Q0A9L5;
DT   17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   17-OCT-2006, sequence version 1.
DT   07-JUN-2017, entry version 73.
DE   SubName: Full=Isocitrate dehydrogenase, NADP-dependent {ECO:0000313|EMBL:ABI56472.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:ABI56472.1};
GN   OrderedLocusNames=Mlg_1121 {ECO:0000313|EMBL:ABI56472.1};
OS   Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Chromatiales;
OC   Ectothiorhodospiraceae; Alkalilimnicola.
OX   NCBI_TaxID=187272 {ECO:0000313|EMBL:ABI56472.1, ECO:0000313|Proteomes:UP000001962};
RN   [1] {ECO:0000313|Proteomes:UP000001962}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1101 / DSM 17681 / MLHE-1
RC   {ECO:0000313|Proteomes:UP000001962};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T.,
RA   King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T.,
RA   Xie G., Stolz J.F., Richardson P.;
RT   "Complete sequence of Alkalilimnicola ehrilichei MLHE-1.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP000453; ABI56472.1; -; Genomic_DNA.
DR   RefSeq; WP_011628867.1; NC_008340.1.
DR   ProteinModelPortal; Q0A9L5; -.
DR   STRING; 187272.Mlg_1121; -.
DR   EnsemblBacteria; ABI56472; ABI56472; Mlg_1121.
DR   KEGG; aeh:Mlg_1121; -.
DR   eggNOG; ENOG4105E9K; Bacteria.
DR   eggNOG; COG2838; LUCA.
DR   HOGENOM; HOG000240860; -.
DR   KO; K00031; -.
DR   OMA; RDSGKMW; -.
DR   OrthoDB; POG091H0B3N; -.
DR   Proteomes; UP000001962; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001962};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:ABI56472.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001962}.
FT   REGION      135    142       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       352    352       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       554    554       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     148    148       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     549    549       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        257    257       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        422    422       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   744 AA;  83264 MW;  35FE26DE07D4CB1F CRC64;
     MTDTATNTIY YTLTDEAPAL ATRSLLPVVQ TFTGAAGIDV KLSDISLAGR ILSAFPERLS
     DDQKVEDGLA FLGDLTQDPN ANIIKLPNIS ASIPQLNACI RELQSQGYDV PSYPAEPKND
     EEQAIHDRYA KVLGSAVNPV LREGNSDRRA PRAVKNFVRK HPHSMGKWSK ASRTHADYMR
     GGDFYSAEQS VTMPQAGTVR IEFVDKDGNV TLKKKLELET GEIIDSMRMS VNALRDFLEE
     TMEDAKDSQV MWSLHVKATM MKVSHPIVFG HAVKVYYKEV FEKWGDLFKE LGVNPNDGLS
     SVYEKIETLP RSQQEEIHRD ILAVYEHRPE MAMVDSYKGI TNLHMPSDVI VDASMPAMIR
     NGGKMWGPDG KPKDCKAVMP ESTYSKIYQE MINFCKTNGA FDPTTMGTVP NVGLMAKKAE
     EYGSHDKTFE LEADGIMRIV DHKGHVLMQH EVEKGDIWRA CQTKDIAVRD WVKLAVRRAR
     EADTPAIFWL DRNRPHDIEL IKKVNCYLQE HDLSGLDIRI QTYEEAIRRS MERALRGRDT
     ISVTGNVLRD YLTDLFPILE LGTSAKMLSI VPLLKGGGMY ETGAGGSAPK HVQQLQEENH
     LRWDSLGEFL AIAVSLDELG MKQDNARARV LAQCLDQATE EALENEKSPS RKTGELDNRG
     SHYWLALYWA EAVAAQTEDK ELADHFGPVA KQLKEKKEQI LEELSVVQGS PADLDGYYHP
     SPEVADKVMR PSPTLNGILA DAMK
//
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