ID Q0AXS5_SYNWW Unreviewed; 365 AA.
AC Q0AXS5;
DT 17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 17-OCT-2006, sequence version 1.
DT 01-MAY-2013, entry version 53.
DE RecName: Full=6-phosphofructokinase;
DE Short=Phosphofructokinase;
DE EC=2.7.1.11;
DE AltName: Full=Phosphohexokinase;
GN Name=pfkA; OrderedLocusNames=Swol_1170;
OS Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen).
OC Bacteria; Firmicutes; Clostridia; Clostridiales; Syntrophomonadaceae;
OC Syntrophomonas.
OX NCBI_TaxID=335541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Goettingen;
RX PubMed=21966920; DOI=10.1111/j.1462-2920.2010.02237.x;
RA Sieber J.R., Sims D.R., Han C., Kim E., Lykidis A., Lapidus A.L.,
RA McDonnald E., Rohlin L., Culley D.E., Gunsalus R., McInerney M.J.;
RT "The genome of Syntrophomonas wolfei: new insights into syntrophic
RT metabolism and biohydrogen production.";
RL Environ. Microbiol. 12:2289-2301(2010).
CC -!- CATALYTIC ACTIVITY: ATP + D-fructose 6-phosphate = ADP + D-
CC fructose 1,6-bisphosphate.
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 3/4.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the phosphofructokinase family.
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DR EMBL; CP000448; ABI68479.1; -; Genomic_DNA.
DR RefSeq; YP_753850.1; NC_008346.1.
DR ProteinModelPortal; Q0AXS5; -.
DR STRING; 335541.Swol_1170; -.
DR EnsemblBacteria; ABI68479; ABI68479; Swol_1170.
DR GeneID; 4283745; -.
DR KEGG; swo:Swol_1170; -.
DR PATRIC; 23857165; VBISynWol51738_1242.
DR eggNOG; COG0205; -.
DR HOGENOM; HOG000248869; -.
DR KO; K00850; -.
DR OMA; TVPLERY; -.
DR UniPathway; UPA00109; UER00182.
DR GO; GO:0005945; C:6-phosphofructokinase complex; IEA:InterPro.
DR GO; GO:0003872; F:6-phosphofructokinase activity; IEA:HAMAP.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006002; P:fructose 6-phosphate metabolic process; IEA:InterPro.
DR GO; GO:0006096; P:glycolysis; IEA:HAMAP.
DR HAMAP; MF_00339; Phosphofructokinase; 1; -.
DR InterPro; IPR012003; ATP_PFK_prok.
DR InterPro; IPR012829; PFK.
DR InterPro; IPR022953; Phosphofructokinase.
DR InterPro; IPR015912; Phosphofructokinase_CS.
DR InterPro; IPR000023; Phosphofructokinase_dom.
DR Pfam; PF00365; PFK; 1.
DR PIRSF; PIRSF000532; ATP_PFK_prok; 1.
DR PRINTS; PR00476; PHFRCTKINASE.
DR SUPFAM; SSF53784; Ppfruckinase; 1.
DR TIGRFAMs; TIGR02483; PFK_mixed; 1.
DR PROSITE; PS00433; PHOSPHOFRUCTOKINASE; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Cytoplasm; Glycolysis; Kinase;
KW Magnesium; Metal-binding; Nucleotide-binding; Transferase.
FT NP_BIND 24 28 ATP (By similarity).
FT NP_BIND 168 172 ATP (By similarity).
FT NP_BIND 185 201 ATP (By similarity).
FT ACT_SITE 141 141 Proton acceptor (By similarity).
FT METAL 199 199 Magnesium; via carbonyl oxygen (By
FT similarity).
FT METAL 201 201 Magnesium (By similarity).
FT BINDING 176 176 Substrate (By similarity).
FT BINDING 281 281 Substrate (By similarity).
FT BINDING 287 287 Substrate (By similarity).
FT BINDING 290 290 Substrate (By similarity).
SQ SEQUENCE 365 AA; 39123 MW; 37E1B3E18CAD9047 CRC64;
MKEIRHIGIL TGGGDCPGLN AVIRAISKTA INYGVEVIGF IDGFKGLVEN RYIQLDLRAV
SGISHTGGTI LGTSNRDNPF QFFTISEGTP QHSDESDRAV ANMEHLGLDG LVVIGGDGSL
NIADRFAEKG VPIVGVPKTI DNDLSATDVT FGFNTAVNTA SEALDRLHTT AESHHRVMVL
EVMGRYAGWI ALHAGISGGA DVILIPEIPY NMDAVISKIT QRYRQGKNFS IIVVAEGAIP
EDGEMVIRNL VATSHDPIRL GGIGQKVAED IGNRLQNIEV RVTVLGHLQR GGSPIPYDRI
LSTRYGVAAV DAFMAGQFGT MVSLRGDMIA AVPIKEAIKE IRRVKPESDL VRAARAVGIS
FGDKY
//
