GenomeNet

Database: UniProt/TrEMBL
Entry: Q0RKL6_FRAAA
LinkDB: Q0RKL6_FRAAA
Original site: Q0RKL6_FRAAA 
ID   Q0RKL6_FRAAA            Unreviewed;       739 AA.
AC   Q0RKL6;
DT   05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2006, sequence version 1.
DT   07-JUN-2017, entry version 73.
DE   SubName: Full=Isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase) (IDH) {ECO:0000313|EMBL:CAJ61941.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:CAJ61941.1};
GN   Name=icd {ECO:0000313|EMBL:CAJ61941.1};
GN   OrderedLocusNames=FRAAL3297 {ECO:0000313|EMBL:CAJ61941.1};
OS   Frankia alni (strain ACN14a).
OC   Bacteria; Actinobacteria; Frankiales; Frankiaceae; Frankia.
OX   NCBI_TaxID=326424 {ECO:0000313|EMBL:CAJ61941.1, ECO:0000313|Proteomes:UP000000657};
RN   [1] {ECO:0000313|EMBL:CAJ61941.1, ECO:0000313|Proteomes:UP000000657}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ACN14a {ECO:0000313|Proteomes:UP000000657};
RX   PubMed=17151343; DOI=10.1101/gr.5798407;
RA   Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA   Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N.,
RA   Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N.,
RA   Francino M.P., Goltsman E., Huang Y., Kopp O.R., Labarre L.,
RA   Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E.,
RA   Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z.,
RA   Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D.,
RA   Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R.;
RT   "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT   reflect host range and host plant biogeography.";
RL   Genome Res. 17:7-15(2007).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CT573213; CAJ61941.1; -; Genomic_DNA.
DR   RefSeq; WP_011604445.1; NC_008278.1.
DR   ProteinModelPortal; Q0RKL6; -.
DR   STRING; 326424.FRAAL3297; -.
DR   KEGG; fal:FRAAL3297; -.
DR   eggNOG; ENOG4105E9K; Bacteria.
DR   eggNOG; COG2838; LUCA.
DR   HOGENOM; HOG000240860; -.
DR   KO; K00031; -.
DR   OMA; RDSGKMW; -.
DR   Proteomes; UP000000657; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000657};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:CAJ61941.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000657}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  78830 MW;  4CE83F7D1CC98A7C CRC64;
     MTDSTIIYTH TDEAPALATY SFLPVVQAYA ATAGVPVESR DISLAGRIIA SFPEHLEPGQ
     RIDDALAELG ELAKTPGANI IKLPNISASI PQLKAAVAEL QQQGYALPDY PDDPRTDAER
     DIRARYDRIK GSAVNPVLRE GNSDRRAPAS VKAYARAHPH RMGAWSAESK TNVATMGADD
     FRSTEKSVIL PADDTLRIEL VGDDGSTSVL LPALPVLAGE VIDAAVLRVA ALREFLTAQI
     ARAKAEGVLF SLHLKATMMK VSDPIIFGHG VRAFFPRTFA TYGQVLAAAG LTPNDGLGGI
     LKGLDALPDG AAIRASFEAE LAEGPALAMV DSDRGITNLH VPSDIIVDAS MPAMIRTSGH
     MWGPDGAEAD TLAVLPDSSY AGIYQVVIDD CRAHGAYDPA TMGSVPNVGL MAQKAEEYGS
     HDKTFEIATT GTVRVVNAAG EAVLEQAVSA GDIFRACQTK DAPIRDWVKL AVTRARATGD
     PAVFWLDAAR AHDARLIEKV QAYLPEYDTA GLTIEIKAPV DAIAFSLQRI RRGENTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLM NGGGLFETGA GGSAPKHVQQ LVKENYLRWD
     SLGEFLALAV SFEQFALSTG NSRAKVLADT LDRATATFLN EDKSPARRVG GIDNRGSHFY
     LSLYWAQELA AQTDDAALAE AFAPLAKTLT DQEQTIAEEL LAVQGNPADI GGYYQPDPVK
     ATEIMRPSKS FNEALALLG
//
DBGET integrated database retrieval system