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Entry: Q0RNP3_FRAAA
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ID   Q0RNP3_FRAAA            Unreviewed;       461 AA.
AC   Q0RNP3;
DT   05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2006, sequence version 1.
DT   11-JUN-2014, entry version 66.
DE   RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase;
DE            EC=6.3.2.9;
DE   AltName: Full=D-glutamic acid-adding enzyme;
DE   AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase;
GN   Name=murD; OrderedLocusNames=FRAAL2194;
OS   Frankia alni (strain ACN14a).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Frankineae; Frankiaceae; Frankia.
OX   NCBI_TaxID=326424;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ACN14a;
RX   PubMed=17151343; DOI=10.1101/gr.5798407;
RA   Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA   Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N.,
RA   Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N.,
RA   Francino M.P., Goltsman E., Huang Y., Kopp O.R., Labarre L.,
RA   Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E.,
RA   Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z.,
RA   Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D.,
RA   Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R.;
RT   "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT   reflect host range and host plant biogeography.";
RL   Genome Res. 17:7-15(2007).
CC   -!- FUNCTION: Cell wall formation. Catalyzes the addition of glutamate
CC       to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + UDP-N-acetylmuramoyl-L-alanine +
CC       glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-
CC       glutamate.
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the MurCDEF family.
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DR   EMBL; CT573213; CAJ60843.1; -; Genomic_DNA.
DR   RefSeq; YP_712422.1; NC_008278.1.
DR   ProteinModelPortal; Q0RNP3; -.
DR   STRING; 326424.FRAAL2194; -.
DR   GeneID; 4231936; -.
DR   KEGG; fal:FRAAL2194; -.
DR   PATRIC; 21914100; VBIFraAln347_2007.
DR   eggNOG; COG0771; -.
DR   HOGENOM; HOG000049429; -.
DR   KO; K01925; -.
DR   OMA; QLHYTHT; -.
DR   OrthoDB; EOG6JB189; -.
DR   BioCyc; FALN326424:GJ82-2161-MONOMER; -.
DR   UniPathway; UPA00219; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0008764; F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-HAMAP.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.1190.10; -; 1.
DR   Gene3D; 3.40.50.720; -; 1.
DR   Gene3D; 3.90.190.20; -; 1.
DR   HAMAP; MF_00639; MurD; 1.
DR   InterPro; IPR004101; Mur_ligase_C.
DR   InterPro; IPR013221; Mur_ligase_cen.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR005762; UDP-N-AcMur-Glu_ligase.
DR   Pfam; PF08245; Mur_ligase_M; 1.
DR   SUPFAM; SSF53244; SSF53244; 1.
DR   SUPFAM; SSF53623; SSF53623; 1.
DR   TIGRFAMs; TIGR01087; murD; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell cycle; Cell division; Cell shape;
KW   Cell wall biogenesis/degradation; Complete proteome; Cytoplasm;
KW   Ligase; Nucleotide-binding; Peptidoglycan synthesis.
FT   NP_BIND     125    131       ATP (By similarity){EA2}.
SQ   SEQUENCE   461 AA;  46576 MW;  FA8326E501061A83 CRC64;
     MASPAEPAGP RAWAGLSVLV VGVGVSGLAA ARALLARGAR VRVVDAGDTE RHRAAAADLR
     ALGATVVLGG LPAGPGGAGL VVTSPGVPPT APLITGSAAA GVPVWGEVEL AWRWRGATRW
     LAVTGTNGKT TTTEMLGAML AAGGRRAITA GNIGTPIVEA VAAEPPYDTL AVELSSFQLH
     YTHTVAPLAA AVLNVAPDHL DWHGGAQAYA EAKARIWRDP ATIAIGNADD AASARLLAGA
     PGRRVLFGRD PAARPAPGLT VEAGHLVDHA FGGGRLVAVR DLRVTGPHLI SNALAAAALA
     RAEGVDPAAI GAALAEFRAG AHRNAEVAVI DGVRWVDDSK ATNPHAAAAS LAGYPSVVWI
     AGGLNKGLAF DELVRDARGV LRGAVLIGRC ADEIAVALAR HAPDVPVERA AGMDDAVRAA
     AALARAGDTV LLAPAAASMD MFRDYAARGD LFAEAVRARE G
//
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