ID   Q13FK5_PARXL            Unreviewed;       798 AA.
AC   Q13FK5;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   24-JAN-2024, entry version 100.
DE   SubName: Full=Betaine-aldehyde dehydrogenase {ECO:0000313|EMBL:ABE37134.1};
DE            EC=1.2.1.3 {ECO:0000313|EMBL:ABE37134.1};
GN   ORFNames=Bxe_C1274 {ECO:0000313|EMBL:ABE37134.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE37134.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE37134.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE37134.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M., Lao V.,
RA   Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A., Marx C.J.,
RA   Parnell J.J., Ramette A., Richardson P., Seeger M., Smith D., Spilker T.,
RA   Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B., Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome
RT   shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|PIRNR:PIRNR036490, ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; CP000272; ABE37134.1; -; Genomic_DNA.
DR   RefSeq; WP_011494360.1; NZ_CP008761.1.
DR   AlphaFoldDB; Q13FK5; -.
DR   STRING; 266265.Bxe_C1274; -.
DR   KEGG; bxb:DR64_8539; -.
DR   KEGG; bxe:Bxe_C1274; -.
DR   PATRIC; fig|266265.5.peg.9025; -.
DR   eggNOG; COG1012; Bacteria.
DR   OrthoDB; 6187633at2; -.
DR   Proteomes; UP000001817; Chromosome 3.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0043878; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; IEA:UniProtKB-EC.
DR   CDD; cd07111; ALDH_F16; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR011408; Aldehyde_DH.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR11699:SF211; ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1; 1.
DR   PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 2.
DR   PIRSF; PIRSF036490; Aldedh_dupl; 1.
DR   SUPFAM; SSF53720; ALDH-like; 2.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345}.
FT   DOMAIN          41..487
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   DOMAIN          541..765
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        266
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   798 AA;  85677 MW;  A670D297C41B61FE CRC64;
     MSVAEYFSSM EYGPAPESDQ AARAWLAQHE ARFGHFIGGA WREPGAGERF ASHAPASGEP
     LAQIAHGDAG DIDAAVCAAR AAQPAWLALG GAGRARHLYA LARMVQRHSR LFAVLEALDN
     GKPIRETRDI DVPLVARHFL HHAGWAQLQE SEFAAYAPLG VIGQIVPWNF PLLMLAWKIA
     PAIAMGNCVV LKPAEYTPLT ALLFAELAHR AGLPAGVLNV VTGDGRTGAA LVEHPQIDKI
     AFTGSTEVGK AIRAVTAGSG KSLTLELGGK SPFIVFDDAD LDGAVEGVVD AIWFNQGQVC
     CAGSRLLVQE GIEARFIARL KRRMETLRIG SSLDKSIDIG AIVDPVQLER IRSLVETGRR
     EGCAVWQSPG TVLPAQGCFY PPTLVTGVAP ASTLAQQEIF GPVLVAMSFR TPDEAIALAN
     NSRYGLAASV WSETIGRALD IAPRLACGVV WINATNLFDA AVGFGGYRES GYGREGGREG
     IYEYLKPRAW LNLGWRQPRN AETVADQPER SLNVMAIDRV DRTAKLFIGG KQVRPDSGYS
     LPVYAPDGTP VGEVGEGNRK DIRNAVEAAR AAHKWSQASA HNRAQVLFYL AENLSVRADE
     FARQLMQRNG ATEAVARAEV EASVTRLFTY AAWADKFDGA VHTPPLRGVA LAMHEPLGVI
     GIACPDEAPL LGFVSLMAPA LAMGNRVIVL PGQACPLAVT DFYQVAETSD VPGGVLNVIT
     GERGALLPAL ARHNDVDALW CFGSAADSTL VERESAGNLK RTFTDYGRQF DWFDPSSEGL
     PFLREAVQVK NIWVPYGD
//