ID Q15T02_PSEA6 Unreviewed; 897 AA.
AC Q15T02;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 01-MAY-2013, entry version 52.
DE RecName: Full=DNA gyrase subunit A;
DE EC=5.99.1.3;
GN Name=gyrA; OrderedLocusNames=Patl_2470;
OS Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC Pseudoalteromonadaceae; Pseudoalteromonas.
OX NCBI_TaxID=342610;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T6c / ATCC BAA-1087;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R.,
RA Gilna P., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Kim E., Karls A.C., Bartlett D., Higgins B.P., Richardson P.;
RT "Complete sequence of Pseudoalteromonas atlantica T6c.";
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC stranded DNA in an ATP-dependent manner and also catalyzes the
CC interconversion of other topological isomers of double-stranded
CC DNA rings, including catenanes and knotted rings (By similarity).
CC -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC of double-stranded DNA.
CC -!- SUBUNIT: Heterotetramer, composed of two GyrA and two GyrB chains.
CC Within the heterotetramer, GyrA contains the active site tyrosine
CC that forms a covalent intermediate with the DNA, while GyrB
CC contributes the cofactor binding sites and catalyzes ATP
CC hydrolysis (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the topoisomerase GyrA/ParC subunit family.
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DR EMBL; CP000388; ABG40986.1; -; Genomic_DNA.
DR RefSeq; YP_662040.1; NC_008228.1.
DR ProteinModelPortal; Q15T02; -.
DR SMR; Q15T02; 30-521, 535-860.
DR STRING; 342610.Patl_2470; -.
DR EnsemblBacteria; ABG40986; ABG40986; Patl_2470.
DR GeneID; 4174224; -.
DR KEGG; pat:Patl_2470; -.
DR PATRIC; 23050128; VBIPseAtl25434_2642.
DR eggNOG; COG0188; -.
DR HOGENOM; HOG000076278; -.
DR KO; K02469; -.
DR OMA; IAQEDVV; -.
DR BioCyc; PATL342610:GHGT-2554-MONOMER; -.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0003918; F:DNA topoisomerase type II (ATP-hydrolyzing) activity; IEA:HAMAP.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR GO; GO:0006261; P:DNA-dependent DNA replication; IEA:HAMAP.
DR Gene3D; 1.10.268.10; -; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 3.90.199.10; -; 1.
DR HAMAP; MF_01897; GyrA; 1; -.
DR InterPro; IPR024946; Arg_repress_C-like.
DR InterPro; IPR005743; GyrA.
DR InterPro; IPR006691; GyrA/parC_pinwhl.
DR InterPro; IPR002205; Topo_IIA_A/C.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a.
DR InterPro; IPR013760; Topo_IIA_like_dom.
DR Pfam; PF03989; DNA_gyraseA_C; 6.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR TIGRFAMs; TIGR01063; gyrA; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW Nucleotide-binding; Topoisomerase.
FT ACT_SITE 122 122 O-(5'-phospho-DNA)-tyrosine intermediate
FT (By similarity).
SQ SEQUENCE 897 AA; 99934 MW; F4F51E3E5DB21B2A CRC64;
MTDHAQEILP INIEEELKNS YLDYAMSVIV GRALPDVRDG LKPVHRRVLF AMNELKNDFN
KPYKKSARVV GDVIGKYHPH GDSAVYDTIV RMAQPFSLRY MLVDGQGNFG SVDGDSAAAM
RYTEIRMAKI SHELLADLEK ETVDFVPNYD GTEFIPDVLP TKVPNLLING SSGIAVGMAT
NIPPHNLTEV VNGCIALIDK PELSIEELME YIPGPDFPTA AFISGRKGIE EAYRTGRGKI
YMRARAEIER EDNGKETIVV HEIPYQVNKA RLIEKIAELV KEKKIEGISA LRDESDKDGM
RIVVEVKRNE SGEVLLNHLY SQTQMQTVFG INMVALDKTQ PKVFNLLEIL QAFVLHRREV
VTRRTVFELK KARERAHILE GLAIALANID PIIALIKASK SPSDAKISLT AQGWALGDVS
DMLERAGNDA ARPDWLEPEF GIRDGLYYLT EQQAQAILDL RLNKLTGLEH EKILSEYKEL
LDLIAELLHI LGSPERLMEV IREELEKIRD EFGDERRTEI TAASHDIDIE DLIEREEVVV
TLSREGYVKY QKLNDYESQR RGGKGKSATK MKEEDFIEKL LVANTHDHIL CFSTRGRLYW
LKVYQLPLAS RNARGRPIVN ILPLEANERI TAILPIQEFE EGKYVLMATA NGTVKKTALV
QYSRPRANGI IAVNLNDGDE LIGVDITDGS SDIMLFSDAG KVVRFNEKAR DSETGAVKID
PETGEEILAL RPMGRTATGV RGIRLQDGQK VVSLIVPQGD GAILTATENG FGKRTPVEDY
PAKSRATQGV VSIKVSERNG KVVGAVQVND SDEIMLISDQ GTLVRTRVGE VSTVGRNTQG
VRLIRTGEDE HVVGLQRIDE VEELEEELEA LAEGDETVEA AASDVDNTTD EDPQNEE
//
