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Database: UniProt/TrEMBL
Entry: Q17HJ9_AEDAE
LinkDB: Q17HJ9_AEDAE
Original site: Q17HJ9_AEDAE 
ID   Q17HJ9_AEDAE            Unreviewed;       735 AA.
AC   Q17HJ9;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   25-JUL-2006, sequence version 1.
DT   27-SEP-2017, entry version 67.
DE   RecName: Full=Angiotensin-converting enzyme {ECO:0000256|RuleBase:RU361144};
DE            EC=3.4.-.- {ECO:0000256|RuleBase:RU361144};
GN   Name=5575537 {ECO:0000313|VectorBase:AAEL002676-PA};
GN   ORFNames=AAEL002676 {ECO:0000313|EMBL:EAT46108.1};
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT46108.1, ECO:0000313|Proteomes:UP000008820};
RN   [1] {ECO:0000313|EMBL:EAT46108.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT46108.1};
RA   Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA   Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA   Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G.,
RA   Utterback T., Rogers Y.-H., Kravitz S., Fraser C.M.;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EAT46108.1, ECO:0000313|Proteomes:UP000008820, ECO:0000313|VectorBase:AAEL002676-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT46108.1}, and Liverpool/LVPib12
RC   {ECO:0000313|Proteomes:UP000008820,
RC   ECO:0000313|VectorBase:AAEL002676-PA};
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M.,
RA   Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J.,
RA   Sinkins S.P., Hogenkamp D.G., Amedeo P., Arensburger P.,
RA   Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V.,
RA   Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B.,
RA   DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M.,
RA   Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H.,
RA   Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S.,
RA   Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D.,
RA   Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A.,
RA   Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D.,
RA   White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A.,
RA   Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J.,
RA   Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B.,
RA   Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
RN   [3] {ECO:0000313|EMBL:EAT46108.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT46108.1};
RG   VectorBase;
RL   Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|VectorBase:AAEL002676-PA}
RP   IDENTIFICATION.
RC   STRAIN=Liverpool/LVPib12 {ECO:0000313|VectorBase:AAEL002676-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361144};
CC       Note=Binds 1 zinc ion per subunit.
CC       {ECO:0000256|RuleBase:RU361144};
CC   -!- SIMILARITY: Belongs to the peptidase M2 family.
CC       {ECO:0000256|RuleBase:RU361144}.
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DR   EMBL; CH477248; EAT46108.1; -; Genomic_DNA.
DR   RefSeq; XP_001662041.1; XM_001661991.1.
DR   ProteinModelPortal; Q17HJ9; -.
DR   STRING; 7159.AAEL002676-PA; -.
DR   EnsemblMetazoa; AAEL002676-RA; AAEL002676-PA; AAEL002676.
DR   KEGG; aag:AaeL_AAEL002676; -.
DR   VectorBase; AAEL002676-RA; AAEL002676-PA; AAEL002676.
DR   eggNOG; KOG3690; Eukaryota.
DR   eggNOG; ENOG410XPJ3; LUCA.
DR   HOGENOM; HOG000046399; -.
DR   InParanoid; Q17HJ9; -.
DR   KO; K01283; -.
DR   OMA; ICQASAW; -.
DR   OrthoDB; EOG091G033S; -.
DR   PhylomeDB; Q17HJ9; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008241; F:peptidyl-dipeptidase activity; IEA:InterPro.
DR   CDD; cd06461; M2_ACE; 1.
DR   InterPro; IPR001548; Peptidase_M2.
DR   PANTHER; PTHR10514; PTHR10514; 1.
DR   Pfam; PF01401; Peptidase_M2; 1.
DR   PRINTS; PR00791; PEPDIPTASEA.
PE   3: Inferred from homology;
KW   Carboxypeptidase {ECO:0000256|RuleBase:RU361144};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008820};
KW   Glycoprotein {ECO:0000256|RuleBase:RU361144};
KW   Hydrolase {ECO:0000256|RuleBase:RU361144};
KW   Metal-binding {ECO:0000256|RuleBase:RU361144};
KW   Metalloprotease {ECO:0000256|RuleBase:RU361144};
KW   Protease {ECO:0000256|RuleBase:RU361144};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008820};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Zinc {ECO:0000256|RuleBase:RU361144}.
FT   SIGNAL        1     28       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        29    735       Angiotensin-converting enzyme.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5010842154.
SQ   SEQUENCE   735 AA;  86153 MW;  1759CA64C5F05617 CRC64;
     MAAFAAKLAL LRVALCVIAI SSVVFGEAEP QLNLPPYGGA VTPTGRPQIL PNSYTGGPGG
     QQQQGDSRKE GNNYDQSRSE RFGPPYEDGD DDEENYPQGR SNDDRQDRQN RPFSYDDRNQ
     YRNDDDYDYR NRNRNPYDRD RNRYVSDVDN PDLYQNRQPY NPNQGDRFRN PDGRYNPNQR
     PYVSDVDNPD LYQDRNPPPY SRNPNDDRFD PNRRPQFGPP NERDFERGRP RDSFFQGPFR
     SPEEERRFQA ETEKLRSFLT EIDRKSSLEC SLNVGAQWNF ETNVNEATQV EAIAAQQRYN
     DFQRLLWVQM SRIDQSKIFD DKLYRQVRLM SIIGPSALPP DQLDRYNRIV NDMLAIFNGA
     DICAFERPFE CGLRLQPHLK EIMAKSRDWN ELQYTWLEWR RKSGRHMREL FEQLVDLTND
     AGRVNNFTNA AAYWQFPYES RNFREEMEQV WNEILPLYEM IHAYVRRKLR EFYGPDKINR
     NAPLPDHILG DMYGQSWNNI LDIVIPYPGR SFLEVTPEMI KQGYNPLVMF QIAEEFFVSM
     NMSALPPDFW LTSIFTQPPD RPVLCQPSAW DFCNGKDYRI KMCTSVTHKD FITVHHELAH
     VQYFLNYRNN PKVFRDGANP GFHEAIGDAV TLSVASPKHL QNLGLVQKNV DDTAHDINFL
     FSLALEKVVF LPFALALEAW RYDIFDKRVR KEQYNCHWWL LREQFGGVKP SVLRSELDFD
     PGAKYHVAAN IPYVK
//
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