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Database: UniProt/TrEMBL
Entry: Q17MD0_AEDAE
LinkDB: Q17MD0_AEDAE
Original site: Q17MD0_AEDAE 
ID   Q17MD0_AEDAE            Unreviewed;      1059 AA.
AC   Q17MD0;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   25-JUL-2006, sequence version 1.
DT   25-OCT-2017, entry version 81.
DE   RecName: Full=Histone deacetylase {ECO:0000256|SAAS:SAAS00894283};
DE            EC=3.5.1.98 {ECO:0000256|SAAS:SAAS00894283};
GN   Name=5568333 {ECO:0000313|VectorBase:AAEL001069-PA};
GN   ORFNames=AAEL001069 {ECO:0000313|EMBL:EAT47819.1};
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT47819.1, ECO:0000313|Proteomes:UP000008820};
RN   [1] {ECO:0000313|EMBL:EAT47819.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT47819.1};
RA   Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA   Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA   Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G.,
RA   Utterback T., Rogers Y.-H., Kravitz S., Fraser C.M.;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EAT47819.1, ECO:0000313|Proteomes:UP000008820, ECO:0000313|VectorBase:AAEL001069-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT47819.1}, and Liverpool/LVPib12
RC   {ECO:0000313|Proteomes:UP000008820,
RC   ECO:0000313|VectorBase:AAEL001069-PA};
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M.,
RA   Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J.,
RA   Sinkins S.P., Hogenkamp D.G., Amedeo P., Arensburger P.,
RA   Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V.,
RA   Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B.,
RA   DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M.,
RA   Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H.,
RA   Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S.,
RA   Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D.,
RA   Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A.,
RA   Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D.,
RA   White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A.,
RA   Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J.,
RA   Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B.,
RA   Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
RN   [3] {ECO:0000313|EMBL:EAT47819.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT47819.1};
RG   VectorBase;
RL   Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|VectorBase:AAEL001069-PA}
RP   IDENTIFICATION.
RC   STRAIN=Liverpool/LVPib12 {ECO:0000313|VectorBase:AAEL001069-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of
CC       a histone to yield a deacetylated histone.
CC       {ECO:0000256|SAAS:SAAS00894227}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00894298}.
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DR   EMBL; CH477207; EAT47819.1; -; Genomic_DNA.
DR   RefSeq; XP_001657988.1; XM_001657938.1.
DR   UniGene; Aae.5683; -.
DR   ProteinModelPortal; Q17MD0; -.
DR   STRING; 7159.AAEL001069-PA; -.
DR   EnsemblMetazoa; AAEL001069-RA; AAEL001069-PA; AAEL001069.
DR   KEGG; aag:AaeL_AAEL001069; -.
DR   VectorBase; AAEL001069-RA; AAEL001069-PA; AAEL001069.
DR   eggNOG; KOG1343; Eukaryota.
DR   eggNOG; COG0123; LUCA.
DR   HOGENOM; HOG000004769; -.
DR   InParanoid; Q17MD0; -.
DR   KO; K11407; -.
DR   OMA; QPHGFCI; -.
DR   OrthoDB; EOG091G0210; -.
DR   PhylomeDB; Q17MD0; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 1.
DR   Gene3D; 3.40.800.20; -; 2.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_domain.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001607; Znf_UBP.
DR   PANTHER; PTHR10625; PTHR10625; 2.
DR   Pfam; PF00850; Hist_deacetyl; 2.
DR   Pfam; PF02148; zf-UBP; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   SMART; SM00290; ZnF_UBP; 1.
DR   SUPFAM; SSF52768; SSF52768; 2.
DR   PROSITE; PS50271; ZF_UBP; 1.
PE   4: Predicted;
KW   Chromatin regulator {ECO:0000256|SAAS:SAAS00894233};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008820};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00870288};
KW   Nucleus {ECO:0000256|SAAS:SAAS00894277};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008820};
KW   Transcription {ECO:0000256|SAAS:SAAS00894309};
KW   Transcription regulation {ECO:0000256|SAAS:SAAS00894290}.
FT   DOMAIN      956   1017       UBP-type. {ECO:0000259|PROSITE:PS50271}.
FT   ZN_FING     956   1017       UBP-type. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00502}.
SQ   SEQUENCE   1059 AA;  118745 MW;  D036C580BFD2393A CRC64;
     MEGSALGPDQ AGVQLKDIYS NAMSSMELVR GETGLVYDER FAEHRCLWDE GYPECPERFT
     RVLERCRELG LVDRCKMIEP RMATEEEILT KHTPEQVEIL RGTKGSEDLE RLEELSSHYD
     AVFVHPSSYD CSLLACGSTI ELVDAVVGGR VQNGMAIIRP PGHHAMKAEY NGYCFFNNVA
     IAAQHALDRL GLKKILVVDW DIHHGQGTQR MFYDDPRVLY FSIHRYECGK FWPNLRESDF
     DYVGEGAGLG YNFNVPLNRI GMANGDYLAI WQQILLPVAM EFQPELVLIS AGYDAAYGCP
     EGQMEITPAF YPHLLTPLMS LAQGRVAVIL EGGYCLSSLA EGGALTLRTL LGDPCPLLVE
     KLQPPCESMQ QTILNCIHTH RPFWKNLQLN DTYGLEELNN VNPQPNFHQV IQYYVQPEPQ
     PEPVRYETRN CYPLQSTEEK ARIEERLAML QIATRLTFPA NRVCFVYDES LLEHRNVHED
     HPEQPDRVAK IYTRHEEYKL LARMKRLKPR HATTTELCMV HSRQHVNVIR RTVEREEMKQ
     VADQFNSVYF HPKTFECATL AAGSVLQVVD EVLNGQSRSG VCIVRPPGHH AESDMPHGFC
     IFNNVAIAAQ YAIRDHGLKR VLIVDWDVHH GNGTQHIFES DPRVLYISVH RYDNGTFFPK
     STDANFDVVG SGSGEGFNVN IPWNKKGMGD QEYSAAFQQV ILPVAYEFDP ELVLVSAGFD
     AAIGDPLGGC KVTPEAYGFF THWLSSLANG RIVVCLEGGY NVNSISHAMA LCTKSLLGDP
     LPMLHLSSRY NGPNAACVET LRNVLSVQEK FWKSLRFNKK LPDFSNVSDA EPDLNGAFSR
     MRLSTSATES SSSSSGSPSS AGSSPVKGKD ESDVPCDGDE QPGPSRKRKT EDPVEAEPSA
     GRCSTGEKHE TLRDFLAANL EALQNEEMFA VVPLRDCPHL KELNPENIPE AISTKSPCTG
     CDSAIENWVC LHCFRVHCAR YINEHAMLHS VEADHAMALS FSDLSVWCYK CESYIDNPVL
     YAYKNLVHRD KFDGEELVWS YGSDLFLDVA KPKPGKTKE
//
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