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Database: UniProt/TrEMBL
Entry: Q1BTA5_BURCA
LinkDB: Q1BTA5_BURCA
Original site: Q1BTA5_BURCA 
ID   Q1BTA5_BURCA            Unreviewed;       318 AA.
AC   Q1BTA5;
DT   11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2006, sequence version 1.
DT   11-JUN-2014, entry version 59.
DE   RecName: Full=Glutathione synthetase;
DE            EC=6.3.2.3;
DE   AltName: Full=GSH synthetase;
DE   AltName: Full=Glutathione synthase;
GN   Name=gshB; OrderedLocusNames=Bcen_2249;
OS   Burkholderia cenocepacia (strain AU 1054).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=331271;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AU 1054;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., LiPuma J.J.,
RA   Konstantinidis K., Tiedje J.M., Richardson P.;
RT   "Complete sequence of chromosome 1 of Burkholderia cenocepacia AU
RT   1054.";
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + gamma-L-glutamyl-L-cysteine + glycine =
CC       ADP + phosphate + glutathione.
CC   -!- COFACTOR: Binds 1 magnesium or manganese ion per subunit (By
CC       similarity).
CC   -!- PATHWAY: Sulfur metabolism; glutathione biosynthesis; glutathione
CC       from L-cysteine and L-glutamate: step 2/2.
CC   -!- SIMILARITY: Belongs to the prokaryotic GSH synthase family.
CC   -!- SIMILARITY: Contains 1 ATP-grasp domain.
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DR   EMBL; CP000378; ABF77150.1; -; Genomic_DNA.
DR   RefSeq; YP_622123.1; NC_008060.1.
DR   ProteinModelPortal; Q1BTA5; -.
DR   STRING; 331271.Bcen_2249; -.
DR   EnsemblBacteria; ABF77150; ABF77150; Bcen_2249.
DR   GeneID; 4092991; -.
DR   KEGG; bcn:Bcen_2249; -.
DR   PATRIC; 19048209; VBIBurCen11237_2348.
DR   eggNOG; COG0189; -.
DR   HOGENOM; HOG000265022; -.
DR   KO; K01920; -.
DR   OMA; DWKIARA; -.
DR   OrthoDB; EOG6WMHWB; -.
DR   BioCyc; BCEN331271:GHKX-2296-MONOMER; -.
DR   UniPathway; UPA00142; UER00210.
DR   GO; GO:0005829; C:cytosol; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0004363; F:glutathione synthase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.30.470.20; -; 1.
DR   Gene3D; 3.40.50.20; -; 1.
DR   HAMAP; MF_00162; GSH_S; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR013816; ATP_grasp_subdomain_2.
DR   InterPro; IPR006284; Glut_synth_pro.
DR   InterPro; IPR004218; GSHS_ATP-bd.
DR   InterPro; IPR004215; GSHS_N.
DR   InterPro; IPR016185; PreATP-grasp_dom.
DR   Pfam; PF02955; GSH-S_ATP; 1.
DR   Pfam; PF02951; GSH-S_N; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   TIGRFAMs; TIGR01380; glut_syn; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Glutathione biosynthesis; Ligase;
KW   Magnesium; Manganese; Metal-binding; Nucleotide-binding.
FT   DOMAIN      129    314       ATP-grasp (By similarity).
FT   NP_BIND     155    211       ATP (By similarity){EA2}.
FT   METAL       285    285       Magnesium or manganese (By
FT                                similarity){EA2}.
FT   METAL       287    287       Magnesium or manganese (By
FT                                similarity){EA2}.
SQ   SEQUENCE   318 AA;  34943 MW;  5F07D34AECEE48DF CRC64;
     MDILFIADPL DHFKIYKDST YAMMAEAARR GHAVYAGEPR HLAWTGSAVE ADVRRITFVG
     ELDDLHRDTW FEAGPVDARR LESFGAVLMR KDPPFDMEYV TSTWLLELAE RAGARVFNKA
     QSIRDHSEKL AIGEFPQFVA PTLVTRDAKR LRAFHAEHGD VILKPLDGMG GMGVFRVKPD
     GMNLGSIVEM LSHDRTRSVM AQKFIPEIKA GDKRILLIGG EPVPYSLARI PQGSEVRGNL
     AAGGLGVAQP LTARDREIAD TLGPVLASRG LLLVGLDAIG DWLTEVNVTS PTCFREIMEQ
     TGFDVAAMFI DALERAAA
//
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