ID Q1D5W2_MYXXD Unreviewed; 14274 AA.
AC Q1D5W2;
DT 11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 140.
DE SubName: Full=Non-ribosomal peptide synthetase/polyketide synthase {ECO:0000313|EMBL:ABF87031.1};
GN OrderedLocusNames=MXAN_3779 {ECO:0000313|EMBL:ABF87031.1};
OS Myxococcus xanthus (strain DK1622).
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Myxococcaceae; Myxococcus.
OX NCBI_TaxID=246197 {ECO:0000313|EMBL:ABF87031.1, ECO:0000313|Proteomes:UP000002402};
RN [1] {ECO:0000313|EMBL:ABF87031.1, ECO:0000313|Proteomes:UP000002402}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DK1622 {ECO:0000313|Proteomes:UP000002402};
RX PubMed=17015832; DOI=10.1073/pnas.0607335103;
RA Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S.,
RA Eisen J.A., Ronning C.M., Barbazuk W.B., Blanchard M., Field C.,
RA Halling C., Hinkle G., Iartchuk O., Kim H.S., Mackenzie C., Madupu R.,
RA Miller N., Shvartsbeyn A., Sullivan S.A., Vaudin M., Wiegand R.,
RA Kaplan H.B.;
RT "Evolution of sensory complexity recorded in a myxobacterial genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- SIMILARITY: In the C-terminal section; belongs to the NRP synthetase
CC family. {ECO:0000256|ARBA:ARBA00029443}.
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DR EMBL; CP000113; ABF87031.1; -; Genomic_DNA.
DR RefSeq; WP_011553792.1; NC_008095.1.
DR STRING; 246197.MXAN_3779; -.
DR EnsemblBacteria; ABF87031; ABF87031; MXAN_3779.
DR GeneID; 41361111; -.
DR KEGG; mxa:MXAN_3779; -.
DR eggNOG; COG0318; Bacteria.
DR eggNOG; COG1020; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_222626_0_0_7; -.
DR OrthoDB; 5526154at2; -.
DR Proteomes; UP000002402; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 5.
DR CDD; cd17646; A_NRPS_AB3403-like; 3.
DR CDD; cd12117; A_NRPS_Srf_like; 2.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd05931; FAAL; 1.
DR CDD; cd19531; LCL_NRPS-like; 11.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.300.30; -; 12.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.40.50.980; -; 20.
DR Gene3D; 1.10.1200.10; ACP-like; 12.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 11.
DR Gene3D; 3.20.20.30; Luciferase-like domain; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 11.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR024011; Biosynth_lucif-like_mOase_dom.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR040097; FAAL/FAAC.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR011251; Luciferase-like_dom.
DR InterPro; IPR036661; Luciferase-like_sf.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR041698; Methyltransf_25.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 10.
DR NCBIfam; TIGR04020; seco_metab_LLM; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00501; AMP-binding; 12.
DR Pfam; PF13193; AMP-binding_C; 9.
DR Pfam; PF00296; Bac_luciferase; 1.
DR Pfam; PF00668; Condensation; 11.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF13649; Methyltransf_25; 1.
DR Pfam; PF00550; PP-binding; 12.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 12.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 13.
DR SUPFAM; SSF47336; ACP-like; 12.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF51679; Bacterial luciferase-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 22.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 10.
DR PROSITE; PS50075; CARRIER; 12.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 10.
PE 3: Inferred from homology;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002402};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 603..680
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2076..2151
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3135..3210
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4193..4268
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5260..5335
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 6325..6401
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 6429..6857
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 7354..7429
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 9672..9747
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 10735..10810
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 11807..11882
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 12865..12940
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 13924..13999
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 680..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5229..5255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6304..6324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6405..6424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7314..7358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9975..9994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 14274 AA; 1551746 MW; 8B2B71725A26103A CRC64;
MHETPRTLLE VLTQRAFSET AHRKQYAFLG DSEGEEASLS ARELHAQAAR IGALLQAQGA
QGQRVLLLYP PGLDYVAGFF GCLYAGAVAV PAYPPDPVRL ERTLPRLRAI IQDAEATVVL
TTSGILSLAD FVFEQAPDFR ALKWLATDEL PAGGESSWIE PQVSPDTLAF LQYTSGSTGT
PKGVMLSHAN LIHNLGLIAG AFQTGPQSSG VIWLPPYHDM GLIGGILQPL FAGFPVTLMS
PMSFLQRPMR WLEAVSRYGG TISGGPNFAF ELCARRATPE DIQALDLRAW DVAFCGAEPI
RAATLDRFAE VFAPSGFRRE AFYPCYGLAE GTLIVTGEEK GRVPRVHVLQ DAALGRGQAV
RVEPGSEGSR PHIGCGSTLA EQRLLIVDPE SRVPCAPGQV GEIWVSGGSV AQGYWRKPED
SVDIFQAVPV GAEAGPKYLR TGDLGLLLED GQLIVTGRRK DLIILRGRNL YPQDVESIVE
RAHRKVRPGC IAAFAIETPE GEALAVVAEV SRDVAEGADP AALGAVADTL RKAIVAELQV
QPHTLALLPP GSVMKTSSGK IQRFACRAAL VSGELPIVWR SGTGVISGPA SLPAPAPAIQ
PALSQEELET ALREELVAVL GAEAVGQDAS TPLTLLGLDS LGAADLQGRV EKRLGVRVSI
AALLQDLSLR SLAESVSAEG TGRRLPPLQR RPAGDAPTPA SFTQERLWYL LQLDPSWTSN
QIPVALTLRG TLDVAALERA LSEVLRRHEV LRTRFASRDG ALLQRVQAAG PVSLPCLDFM
GVRGDARQAT LEAQAVLDAQ HPMDLEAGPL VRCSLLRFGP EDHVLLTVLH HLVVDGTSVA
LFMRELAALY GAFVEGRPSP LAEPEFQYGD FAAWQRAYFT PDALTTELMW WKETLAGAPQ
LLALPTDRSR PQRLSVHGAR RLRLLPASLM ARLHALGRRQ GATPFMSVMS ALATVLHRWS
GQSDFVVGTV ISGRDAAGTR ELMGDCTNFI PLRVRLSEAA TSADMLSEVK SRMLGALAHG
YVPFEQILAA VQLPGAERRE LYNVGFILDD YELPRALSVR GGLTLDVSLV DNHTAELDMT
FEATHRPEGL LIGCKYSADL FDAETADRLL SHLEHVIRGM VDAPEAPLTT LPLMSEADRQ
HALHGWNPRV EAPPFGTLTD LIEAQVERTP DAVAVAFESE RLTYRELDAK ANKLAHHLRG
LGVAPESLVG VCLERSVDMV VALLGVLKAG AAYVPVDPAY PKERLGWMLE DTGASVLLTH
EKWKTVLPPS AARVVCLDSA AGEVAKQPVT KPAVQVGPQA LAYVIFTSGS TGRPKGAMNA
HEGVVNRLKW MQEEYGLSGT DVVLQKTPFS FDVSVWEFFW PLLAGAKLVV ARPGGHQEPA
YLVKLMKAEG VTTVHFVPSM LRAFVEEPGL EGLGSLRRVV CSGEALSAEL VKKAYARLPA
PVRVHNLYGP TEAAVDVTYW PCPRGEDFHR VPIGRPVANT VLYVLDVHGQ PAPVGIPGEL
HIGGVQVGRG YWQRPQLTAE RFIPDAFSGI PGARLYRTGD VARWLPDGTL EYLGRADFQV
KLRGFRIELG EIEAALAADP AVHDSVVLAR EDSTGDQRLV AYVVLDDAAA AQEVDASSQW
QAIYDEAYAR ETTESEDPTF NIVGWEDSYT GESLPPAQMR EWVDTTVAQI LSFQPKRVLE
LGCGTGLLLY RLAPRCEAYW GVDFARPALD RIERQRERMG GALDSVHLLH QSVDDFSALE
PGSFDTVVIN SVVQYFSSPE FLLDVLRGAV RVLKPGGRVF LGDVRSLELL EAFRASVRLH
RTAGPGATSQ FAYRVQRDIL AEKELVLSPA FFTALPERIP GIQRVEVLPK HGRYDNELSR
FRYEVILHVG DAARTPARRT KPDWVDGAGL TLDGLREQLS ARPGLLAVRG LPNARVLEPT
RLVELLSATP PPTVARLREA LHDWSGPRGV EPEDLYVLGS ELGYEVRVSW ASAHRDGALD
VVFAHPDEVG TLDLSPEPKQ VTSWDGLASD PLRGARSAQA VSRLRDALAD KLPPHMVPSA
FVVLPALPLS PNGKVDRKAL PAPEAERLGA ADAFIAPRTP TEEKVARIFG EILGQSRVGA
NDDFFALGGH SLLATQVVVR VRAQLNTEIS LRTLFDAPTV ARLAERIESQ VQLADAPGVP
ALVPLERGPS ADEGLAASFA QQRLWFLEQL HPGQAAYNLP AALRLTGPLD VEALRRTFLE
VVRRHEAVRT TFVTREGQPA QRIHPAPAEW PLPEEDLRGL EPIARDAAVQ ARMAEEAHRA
FDLEKGPLLR TVLLRTGADA HVLLLCMHHI VSDGWSMGVL VREVAALYEA LSQGHEAALP
ALSVQYADYA AWQRRVLEGP ALAPQLDWWR SRLEGAPTLE LPTDHARPAV RTLRGATHAF
TMPPSLVAGL ERVGQEQGAT LFMVLMAGWQ ALLARYSGQT DFCVGTPLAH RTRPELEGLI
GFFVNTLALR ANVDGDPRFD DLVARVREES LAAFANQDVP FDRLVEALGG QRDLSRTPLF
QAAFVLQNAP MQPPTLPGMV VDVLRTGTDT ARFDVTLLLV ERGGRLEGEL EYSLDLFTPD
AARRMVEHFQ RLLRGVSADA ARRISAVPLW SEAERDEVLV AWNDTAAPYP ADTTVHQRFM
EQARRTPERV AVTFEGRSLT YAELDARSNQ LARHLVSLGL ELEARIGVCG SRGLELVIGV
LGALKAGGCY VPLDPSWPMK RLEHVSSAAR LSAVLTWQSL LPSLKDGPWH VVALDADAAD
IARQSTEAVP VPVLPDALAF ATFTSGSTGT PKGVAIPHRG LLRLSEGTRF LTQSPEEVTL
QLSPLAFDVS SVELWGTLLH GGRLVVYPPG TPELDAVARL IIEHKVSWLL LPTSLFGLMQ
QHQPEALLRV PNLMVGGEAL PAPRLRERLA QGGALTNAYG PTECSTMVTR YTLSPGDTVG
LSVPIGRPID NTEVYVLDPA LCPVPVGVPG ELCLGGPGLA RGYLNRPDLT AECFVPHPFS
AVPGARLYRT GDRVRWRPDG VLEFLGRLDH QVKVRGFRIE LGEIEAVLRA HPFVAEATVV
VREDGSGSNR LVAYVVPPQP DVAPLREYLH QHLPDYMLPS AFIGLDAFPL TPTGKVDRKA
LPAPDLGLGA SDFVAPRTEL EQQLAALFRE ALDIERVGLN DDFFLLGGHS LLATQVVTRL
RARLGVELPL RTFFEAPTVA RLAARLESAP RTGAWLPLEP VSRPASGEAT FDVSSAQRRL
WFMEQLHPGL AVNHIPAALR LTGRLDVEAL RRTFLEVVRR HEAVRTTFVT RGGHPAQRIH
PVPSEWPLPV EDLSGLEPIA RDAAVQARMG EEAHRAFDLE RGPLLRTVLL CTGPDAHVLL
LCMHHIISDG WSMGVLVREV GALYEALAQG RESPLPALVV QYADYAAWQR RLLDDPALTP
QLDWWRSRLE GAPTLELPTD HARPAVHGAK GATYFFSLPA EQVAGLERVA LAHNATLYMV
LMAGWQALLA RYSGQTDFTV GTTVAARSRP ELEGLIGVFV NPLALRCRLD GNPTFSELVT
RVREESLGAF AHQEVPFEQL VDALGGERDL SRTPLFQTLF VLLSSDLLQA PSLPGLQIDV
LPNATDTSRF DLTLSMMDRG GALDGQLEYS LELFTPDTAR RMVEHLRVLL AAVADGAGAQ
RLSELPLMDA GERQQVLSTW NATQAAYPVD ATVPSLFAAQ ALKTPHAVAV EHDGRTLTYA
ELDTRSNQLA HHLNALGLGA EARVGVFLHR GLDLLVGLLG ILKAGCAYVP LDPEYPAQRL
AFMAEDSGVA AILTEAALED ELPAGAQVVI VLDDEWTWIE RQPSTPVTGG IVGPDQLAYI
TYTSGSTGTP KGVAIPHRGV VRLLIGSRFV DLGPSEVVLQ LAPLAFDAST LEIWGALLHG
ARLVLYPQRT LDLAELGQAL ERHHVSVLWL TAALFDQMQQ HQPEALRKVR QLLAGGDVLP
APRVRERLAQ GVGLVNGYGP TESTTFTACH RMAAGDAVGD SVSIGRPIAN TQVYVLDPAM
RAAPVGVPGE VFIGGDGLAR GYLGQPALTA ERFVPNPFGP PGARLYRSGD RARWLADGTL
QFLGRVDFQV KLRGFRIELG EIETALRSHS EVETAIALVR EDSPGDRRLV AYVTPEDVDT
ASLREHLRQR LPEYMVPNAV VVLSTLPLSP NGKVDRKALP APDLSPAEDT QTAALPLLQQ
QLATLFREVL RVERVRPQDD FFELGGHSLL ATQLVTRVRA ELGVEVPLRT LFEAPTLAGL
AERIEALMMQ ASRASMPPLE PVPRNAALPL SFAQQRLWFL SQFQKGHAVY NVPFALKLFG
PLDMDALRRT FAEVVSRHEV LRTSFPVTEG LPRQQVNPAP AVWDLPVEDL SAMVGPARDA
RVRQRMIAEA HFPFDLSTGP LFRSVLLRLD ADAYVLLLCV HHIVSDGWSL GVLVREVSAL
YAAFSEGKPS PLPPLAVQYA DFAAWQRQWV LHDGIQTQLT ELRSHLQGVP ALELIGDLSR
PAVRTVRGSS QFFTVSPELV QSLEKVARDQ GATLFMVLLA AYEVLVSRYS GQQDFCVGSP
IAHRTQSELE PLIGFFVNTL ALRARLEGAP TFAELVSRVR EEALAAYVRQ DVPFDRLVEA
MGVERGGGKS PLIQVMFALQ NSPMQLPALA GMRVEPLRSA TETARLDLTL SMMDLGDGAL
EGALEYSTDL FTPEAAKRLI RHFQTLLEAI VRDPEMRIQS LPMLPEDEQH QVLKGFQGRE
MAPASEASIH ALVEAQVART PDAVAVAFES ERLTYRELDA RANQVAHHLR GLGVAPESLV
GVCLERSVDM VVALLGVLKA GAAYVPVDPA YPKERLGWML EDTGASVLLT HEKWKSVLPP
SAARVVCLDS AAGEVAKQPV TKPSVQVGPQ ALAYVIFTSG STGRPKGAMN AHGGVVNRLK
WMQEEYGLSG TDVVLQKTPF SFDVSVWEFF WPLLAGAKLV VARPGGHQEP AYLVKLMKAE
GVTTVHFVPS MLRAFVEEPG LEGLGSLRRV VCSGEALSAE LVKKAYARLP APVGVHNLYG
PTEAAVDVTY WPCPRGEDFH RVPIGRPVAN TVLYVLDVHG QPAPVGIPGE LHIGGVQVGR
GYWQRPQLTA ERFIPDAFSG IPGARLYRTG DVARWLADGT LEYLGRADFQ VKLRGFRIEL
GEVEAALRAH LDVFDAVAVV REDAPGDQRL VAYVTGEPAL DVAALRARLV EQLPAHMVPT
AIETLPSLPL SPNGKVDRKA LPQPRATPAP GAAAPLPVQE RMTPFQQRVA ALFRELLRVE
RVGLHDDFFS LGGHSLLATQ LISRLRTTFG VELSLNALFD APSVASVTEL VEEGMLVRVT
APQIPVLRPV ARDGSLPLSF AQQRLWLIDQ LQPGGSQYNL PGAVRLEGAL DTEALRRALE
SLVKRHEPLR TRFVMRDGDP LQVIDPASDW ALPVTDLTGL PRGDRETEAR RLAATDAGQP
FDLSAGPLLR TLLLKLDADL HVLVLTMHHI VSDGWSLGVI VREVAAAYDA FAQGRGPALP
PLPIQYADFA SWQRQWLQGD VLTAHVDWWK EQLAGAPQVL DLPTDKARPN QRSQFGELYP
IHLSQDVVAP FLALARQAGA TPYMALLAVW QVLLSRYSRQ EDLLVGSPIA GRRHGEVEGL
VGFFVNTLVL RARVRPRDSF RAFLAQVRDT TLAAYEHQDL PFEKLVEELQ PRRDLGRNPL
VQTFFSLLNT PTGPMQATGL TLRPADVDIA TSRFDLGLAL MDDADGLRGA IEYSTDLFEP
ATVARLAGHL RVLVESVAAT PDQPLFTLEM LTPGERHQLL REWNDSPARY DGAGGTIAEV
IARHASLRPF AVALECGDET LTFEQLDTRA NQLANLLRSR GVSTEVLVAV SLERGTAWVI
AMLAVLKAGG AFVPLDASYP AQRLAIMLED APPHLLLASR ANHAKLPLPD GGLPTLLLEE
LDLSEWPTTS PVSDVGPNHL AYVMFTSGST GRPKGVAIPH RGVLRLSHSE PFIRFGVRET
GLVMAPASFD GSVMELWLPL LNGSGVVLYP PEAQASDLDT LSRVVERHGV TLIHFPAGLF
SQVVEHRSDL LKKLRAINVV GDILSAPHTR RTLTTTGVPV TNGYGPTENS IISTSYTAYE
ASQVGASVPI GRPVSNTQAY VLDSQLQLVP VGVPGELYVG GEGLGRGYVS RPDLTAERFI
PAPFATQPGA RLYRTGDLVR WRPDGTLEFI GRIDNQVKVR GFRIELADVE AALRTQPGVL
EAAAVVREDI PGDKRLVAYA MGRDDAPLDV AALRAGMRQR LPEYMVPSVF VVLPTLPLST
SGKVDRKALP APDSASTGRD GHFVEPSSPL AQQLAALWAK ELGTERIGLH DHLFDDLGGT
SLSVVRIAKR MRETLNREVP VVWLFEHPTV DALAAVLERD AKVDEVPAAP ARPEPASEPS
AEAKHATGSG LVAIVGMSGR FPGARSVQDF WRNLRDGVES ISRFTPEQLE RLPGLPEGLE
LSQHPAFVPA GGVLDGIDGF DPGFFDLSLR EAQWMDPQQR LFLQTAWSAL EDAGIDPERT
PEAISLYAGA IDSGYKDAVR ATLPLDGAAL FELYGTATHE SLATKASFKL GLTGESVLIY
TACSTGLVAV HLACQNLLAG RSGVALAGAT RIAVPQRTGY VYQEGMILSP DGHCRSFDAN
AQGTVSGNGV ACVVLKRLED AQRDGDSIYA VIRATATNND GRYKSGYTAP SVQGQAAVIS
QALARSGVRA QDIGYVETHG TATPLGDPIE VAALQRAYGL GVEHRGTIAL ASLKSNMGHL
DTVAGLAGLM KVALSLHHGE VPPSLHFERP NPQIDFDASP FFVNTTLRPW PRTETPRRAA
VSSFGIGGTN AHAVLEESPM AHSGSTTRSH QVVTLSARSA EALEAAARQL AGHAEAHAAD
LSLADVAFTH AVGRKAFEFR RTVVARDAAD LTARLRKPYT PVKVADADVN RRRVAFIFPG
QGAQQAGMGR ELYEAEPAFR AHADACLALL EPALRERVRE VLFAGPGMDA AAVADTRAAL
PALFTVEYSL ARMWMDWGLR PYAVLGHSFG EYAAACLSGV LSLEDAMRLA VARGELMHRM
PPGAMLAVAM PESQVLPLLT GRLSLAAINA PDRCVVAGPI AEVDRLQEEL RRSEVGTVRM
PAPHAFHSAD VEPLMPALAE VVASLQRQAP TLRYASSVTG RWAQANELAQ PDYWAAQMRQ
PVRFTNAVGA LLEEGCSLLL EVGPGQDLTP LVRACLGRDK ERVKAVATLR RGGTTTEHAS
LMTAVGELWT LGVSVDWSVF YGHEQRLRLH LPTYPFQEKR CWVEAPARPA PVAMPSLANG
AGHGSLAAPH ATSPRQVQVQ ETPVPAATPE REDAPRGDIE ERLASLWRER LGLPFVGRDD
NFLEIGGNSL MAAQLLNQVR STFGVQLPLA ALFEAPTVAG IAQRIESLLR QAPVVESSRE
LPIVPLPRNE PLPLSFVQER VWRLEQHLPG LSAYNIPFVL RLEGAVDAVL LERAVQEIIQ
RHESLRTTYD VVDGRPVQRF HARMHIPLVR VDLTGAPEHR EAEAMQLARE DAAKPFDLVK
GPVVRTTLVR LDERLHILLG NIHHIVSDTL SISIFIHELF QCYAAFQQGR PSPLLPLPVQ
YADFGAWQRK VVAEGRLPDQ ESWWRQQLAA MPRQLGIATD RPRPPTSPLT SVRMPVSFSA
ALSREVAGFG KREGYTSYMM VLAAWQALLH RYSGQTDIIV GTPIGNRTRP ELLPLIGYVA
HSAAFRTSFA DDPTFLELLA RVRQEVNDVQ LRPDVPFEHL VEALIPGKDI GRGRLTDTIV
VFHTTAGGAA AALELTGVRG TMMEVPDAPV QWGATLSDLS LVLGDDSGRI GGALEYATEL
FDEATARRIV EHLQVLLGSA LARPSERISR LPLATDADRS AWPAPLPRSV STPVPTRLSQ
RAARQPGATA VLQGATSWTW SDLAQRARNV AARLRALGVQ PGEPVAVCLK PSPTKLAVLW
GVLEAGGAVV AVGSTDLGRL SDFALPGAQV PVLITWRGIM TAARLDAARV LHVEDALESS
GALAERPAPA PEALAWLLPV GANQSPWALV HQGLTELFDA LDMRLRPSEG ATWVAAAESS
AERPELEALW ALSRGLTVTF PSEQVTAQWE VLQGGGPRQG AMDLSLIYFA NDEDSLVGPK
YELLIEGAKY ADANGFSAVW TPERHFHSFG GLYPQPAVVA GALATITRNL SLRSGSVVLP
LHDPLQVAEQ WSVVDNLSGG RAGLSIATGW HVADFTFAPQ NFEDRRNVLL RNLETVRALW
RGEKLRRPGG GGVTVEVGLR PKPVQKELPV WLTAAGSPET FRLAGEVGAG VLTGLLTQSL
EELKQKVALY REAWRRNGHP GRGHVALMLH AFIGDDEQEV LRTVRKPLLS YFRSSAEITA
TLLAAQGYQG EIDKVSEEDV NALLEHTFEH HAKGTGLIGT VESGVQRLLH VREADVDEVA
CLIDFGLDTP VVLEGLRRLT VIRERLVQDA SQRKVQRQAE GTLAVDELLA LARQSGAVLL
HASARLARTL VELPQAREAL EPVGALVLDG ASAELALSLH RNLGTEVLLA GAAGEGGLLP
RPPSERVPEG LQSWVLDAAG LPVPPGVVGE LALEGAGLPW DLWRANEQER RRFVQHPSSS
SARLFRTGRH ARLRVDGRVE HVTLPAAPKV QAPVAAQKPK PKAPSVPALQ PEHSAIPRVP
RTRPLPLSFA QQRLWYLQQL DPSSTAYNNG SSFRLTGPLN VEALQAALNE VVQRHEVLRT
TYQLTEEGAV QLIHAEGSLP MPVEDVPGET PEAREAEMLR RCAALGALPF DLDKGPVARA
VLLRMGLEEH VLSLMQHHVI SDAWCTLVLG RELSVLYACF SAGIPSPLPP LEVQYADYAV
WQRQWLEGAV MEEQVRWWKE RLTSVPALEL PTDRPRPAVQ SYAGGSFRFE LPSDVSEPLL
AFGRREGATS FMVLMALFQA LLGRTAGQED FAVGIPTAGR SRPEVEGLLG CFVNTLALRS
RLEGAPSFRE LLGRVKSQSL DAFAHQDAPF ERIIEALQLP RDQSRTPVFQ AVLNVVNTPT
VDVAHQSLKL SQLGIEADTS KFDLSLEIVE RKNTLFCRFE YASSLFDGGT VQRLAGHLIE
LARAVIVTPD LPLQRVAILS EDERRQVLKG FQGREMAPAS EASIHALMEA QVARTPDAVA
VAFESERLTY RELDAKANQV AHHLRGLGVA PESLVGVCLE RSVDMVVALL GVLKAGAAYV
PVDPAYPKER LGWMLEDTGA SVLLTHEKWK TVLPPSAARV VCLDSAAGEV AKQPVTKPAV
QVGPQALAYV IFTSGSTGRP KGAMNAHGGV VNRLKWMQEE YGLGGTDVVL QKTPFSFDVS
VWEFFWPLLA GAKLVVARPG GHQEPAYLVK LMKAEGVTTV HFVPSMLRAF VEEPGLEGLG
SLRRVVCSGE ALSAELVKKA YARLPAPVGV HNLYGPTEAA VDVTYWPCPR GEDFHRVPIG
RPVANTVLYV LDTHGQPAPV GIPGELHIGG VQVGRGYWQR PQLTAERFIP DAFSGIPGAR
LYRTGDVARW LPDGTLEYLG RADFQVKLRG FRIELGEIET ALRMHPGVRD AVAVVREETR
GDARLVAYVT GDSAPLEAET LRAQLLKQLP QHMVPSTFVH LGVLPLTPSG KVDRKALPAP
EAPTVQRGLY VAPRTPTEEA LAELFAQVLS VGRVGIHDGF FELGGHSLLA TQVVVRVRTR
FGIELPLRAF FESPTVAGLA AYLDGQKNAP AQSDAAVPAL THADRRASLP LSFSQQRLWV
ISQWSETGSS AYNHPLALQL TGALNLPALQ RSFDTLVARH EVLRTTFRME GGAPVQVIHP
PSQVPIEVLD LSGEAVAHLR EAETLRRVQE EVQRPFDLAK GPVVRGILLK QSAAEHVLVL
NMHHIVTDGW SNGVMVREMA AIYGAFRQGQ PSPLPPLPFQ YADFAAWQRK WLQGQVLEAQ
LDYWRGMLAD APPYLELPTD KPRPEQPSFQ GDNTPIQLPA ALSDAVDALA LKERATPFMV
LLSAFQVLLN RYSGQDDVLV GSPIAGRRHA QTEGLIGFFV NTLVLRARFG QDPTFRELLA
QVRDTTLGAY EHQDLPVERL VEDLRPTREE GRTPLFQVMF ALQNTPVPEL TLPELSLRGF
ESKHTVSRFE LELVLSRATE GYQGGLVYST DLFESATAER LVAHLQVLLE EAVTSPDTPV
SALPLEREEA PQPDDAADMA REATFHLRVE EQAARTPDAP AVSLESQVLT YAQLNAKANQ
LAAQLRTMGV GPEVRVGLCL ERTPDAIVAV LAVLKAGGAF VPIDPAAPAQ RKSFVLKDCN
ASVLLTLQHL ADAWKPQVRN LLCLDTEASK LASLPTRNAV VNVLGENLAY VIYTSGSTGT
PKGVMVQHRS LLAMHAGTTE AFQATGATRQ RISLNAPFHF DGALEPLVHL ADGHCLCLVP
EETRKDPEAM LAWVGQQRVD VLDCTPAQLT LLLQAGLLEQ THVPSRIVCA GEAMAPSLWK
QLASTERTTA FNAYGPTEST VCATTASVRN STAPVPVIGR PIQGTRAYVL DARQRVAPAG
IAGELYLSGD GLARGYQGQP QLTAERFIPD AFSGTPGARL YRTGDKARWR HDGTLEYLGR
LDFQVKLRGF RIELGEIEAV LRTHDQVQEA VVLVREDVPG DKRLVAYVVV VVTPEAPVTA
ELLRQHAQER LPEYMVPSAF VLMGTLPLTP TGKVDRKALP VPDVSNLAVK RDVEPPATPL
EAQLAEVWKE LLRVPTVGRR DTFFELGGHS LLATQLVARI RATFDVDLNL RTFFAAPTVA
ALAERLSSAS SGPRLPALTR ARGDGALPLS FAQQRLWFLD QLQPGNASYN MPTALRLSGA
LDVAALQRAV DEIVRRHESL RTTFQTEDGA PRQVIHAPHP VAVDRVDFSG IQDESHREAE
ALKRVTADAR RPFDLTQGPL LRVTLLKLAP SEHVLLLCMH HIISDGWSMG VLVREVTSLY
GAFHAGQPVS LPELPVQYAD YAVWQRGWLQ GDALNQQFSF WKEQLAGAPH ALELPTDKPR
PAFLSTRGAS VPVQLSLAHS QGVETLAQKE GVTPFMVLLA AYHMLLNRYS AQDDVLVGSP
IAGRHHAQTE SLIGFFVNTL VLRARFGREL TFRQLLAQVR DTTLGAYEYQ DLPVERLVEE
LQVERDPSRT PLFQTLFTLQ NAPIPELVLP GLTVRPADGE DTGVALFELS LDLFRGADGF
SGTLNYSTDL YEEATAQRLA SHYQRLLEGV LARPDERVAA LPMMPPEERQ AVLEAASGAR
ETLPKDAHIH ALFEAQVART PDALAVVAGA ESVTYRELDA RANALALRLR AAGVGLEQRV
AVCVERSVEL LVALLGVLKA GGAYVPLDSE YPAERLRFML EDSGARVIVA RAAFRERLGA
AAGCVWLDAE VPPSSGVPQA PAVLVPPEAS AYVLYTSGST GRPKGVVVQH QSLVNFTRAA
WTSFPVAPGD RVLQFASISW DTSAEEIYPC LTSGGTLVLR TPDMLDEPGA FLAKCGAAGV
TQLNLPTAFW HDVTASLDAG TARLPPGLKW VVIGGERVAP ERVAQWQRSV GVELPLLNTY
GLTEVTAVAT SVNLSAAGVL ASPGAEREVP IGRALTNVRM YVLDRELEPV PPGVPGELFI
GGWGVARGYL GRPELTAERF VPSPFVDSER LYRTGDLARW RRDGNLEYLG RGDTQVKVRG
VRIEPGEIEA ALRAHPTVHD AVVHVREDVA GDKRLVAYVV PSSAPSAGQL EASALREHLR
GNLPEYMVPG AFVSLAALPL TPSGKVDRKA LPAPEASQLA LKRDSMPPAT LMEARLAEVW
QELLRVPTVG RHDNFFELGG HSLLATRVVA RVRADFNVEL SLRAFFEAPT VAALAERLGS
ATPGSRLPPL TRARRDGPAP LSFAQQRLWF LDQLQPGNAS YNMPSALRLS GTLDVNALQR
AANALVERHE SLRTTFQAQG GEPRQVIHPP GALPLKVVDL SGLQGRAYRE SEALKRATHD
AQQPFDLSTG PLLRVTLLTL TPTEHVLVLC MHHIISDGWS MGVLVREVAA FYDAVLRGQP
ASLPELPVQF ADYAVWQRGW MQGETLKQHL GWWKEQLAGA PHALDVPTDK PRPAVVSHQG
AGVQVQLPFA LSQALEALAQ KEGVTPFMLL LAAFQALLCR HSGQDDVLVG SPIAGRRQAE
SEPLIGFFVN TLVMRARISP ETTFRQLLAQ VRDTTLGAYE HQDVPFERLV EELQPSRDLS
RTPLFQAIFA LQNAPGSDLA LQDLSLRELE PTHGVSRFEL ELALARLPEG YQGALIYSTE
LFEPATAEQL VEHLRLLLEG AVASPDDPVS TLPLHTEAEQ HQLMVDWNST TSSVQRGGIF
HTRFEQQVGR TPNAPAVALD EQVLSFSQLN AKANQLAAHL RTLGVGPEVR VGLCLERTLE
AIISLLAVLK AGGAFVPIDP MAPSQRRSFM LEDSGATVLL TVQHLAEAWR PQVRHVLCLD
TEAARLASLP TYNVPANVRG ENLAYIIYTS GSTGTPKGVM VQHRSLPWLL QGMTESLEMA
EPAGQRLSLN APLYFDGTVE RLMHLAEGHC LCLVPEATRK DPEAMVAWLE QQRVDMLDCT
PAQLALLLQA GLLERSHVPA RIFCGGEAMS PMLWNRLAST ERTTAFNVYG PTESTVCATS
ARVQGNPSPV PVIGRPIVGT RVYVLDSRQQ LAPLGTAGEL CIAGEGVARG YFGRPGLTAE
RFIPDAFSGQ PGARLYRTGD KARWRHDGTL EYLGRLDFQV KVRGFRIELG EIEAALRTHG
QVQDAVVLAR EDVPGDKRLV AYVVGDFITA ESLRQHLLQR LPEYMVPSVF VPLAALPLTS
TGKVDRNALP TPDASQLALT RDVEPPATPT EARLAEIWKE LLRIPTLGRH DNFFELGGHS
LLATQVVARI RDTFDVELNL RAFFAAPTVA TLAERLASTT PSLRLPPLTR AGRDGALPLS
FAQQRLWFLD QLNPGDVSYN MPSALRLSGT LDVEALRRAV SAMVERHEAL RTTFQSVAGE
PRQVIHPPHA TVVEVVDLSD IQDRAQREAE AMQCATRDAR QPFNLSAGPL LRATLLKLEP
SEHVLLLCLH HIVSDGWSLG VLVREVTTFY EAFHNGHPAA LPELPVQYAD YAVWQRGWLQ
GETLKAQLGW WKSQLAGAPH ALELHTDKPR PAVLRHHGAA VPVQLPQELA LMLDALAQRE
GVTPFMLLLA AFQSVLARHA GQDDVLVGSP IAGRRHAETE PLIGFFVNTL VLRARLTPAM
TFRQLLAQVR DTTLGAYEHQ DVPFERLVEE LQPSRDLSRT PLFQVMFALQ NTQVPELTLP
QLSVRPADAD DSGVTLFELS LDLARAQDGY EGALVYSTEL FERATAERLA THLRLLLERA
VAAPDLALAT LSLHTETEEQ QLMVDWHDLA PARERGALFH TRFEQQAART PEAPAVTLGA
QVLSFAQLDA RANQLASSLR SLGVGPEVRV GLCLERTPDA IVAVLAVLKA GGAFVPIDPS
APAQRKSFVL KDSDASVLLT VQPLADAWKP QVRHLLCLDT GASNLASRPT DDVTVEVRGE
NLAYVIYTSG STGTPKGVMV QHHSLASLHV ASNLAFHLGQ APGQRFSLNA PLYFDVSMDQ
LVHLADGHCL CLLPDDTRRD PEAMLAWLEQ QRVDVLDCTP AQLTLLLQAG LLERAHVPSR
ILCAGEAMDP SLWSRLANTE RTTAFNAYGP TESTVYATYA RVQHSPSPVP VIGKPLAGTR
AFVLDARQQL APLGTAGELY LAGDGLARGY LGQPGLTAER FVPHPFASTP GERLYRTGDK
ARWRHDGTLE YLGRLDFQVK LRGFRIELGE IEAALRAHEA VQDAVVLARE DVPGDKRLVA
YIVGGSATVE ALRQHLQQRL PEYMVPPAFV SLPALPLNPS GKVDRKALPS PTLADTRSQE
AHVAPRDGLE LRLVRTWEQL LGVEPISVRS SFFELGGHSL LAVRLVAALR ESLGRPLPLS
ALFQAPTVEQ LAALLRREDA GPTSSLVPFD AGRSGTEVPF FCVHPVGGNV LAYAELARLL
GPERPFYGLQ AQGLDGSTPP LGTVEEMAAA YVEAIRTVQP AGPYLLGGWS VGGVIAYEMA
RQLRERGDTV ALLALIDAYT PAVLNAAEPE PDAAQVVSAF ASDLLGIGFT DLATPDASLS
PEAQVEALWE AGQRAGALPP GMEPAHLRAL LQVFEANLWA ARRYQPPALN PGRVLRLQAT
EGAEGLPEDG GWKALVGTGL EQHAVSGDHY SVLRAPGVRE LADRLRSALK VTTA
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