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Database: UniProt/TrEMBL
Entry: Q1D6A2_MYXXD
LinkDB: Q1D6A2_MYXXD
Original site: Q1D6A2_MYXXD 
ID   Q1D6A2_MYXXD            Unreviewed;      5741 AA.
AC   Q1D6A2;
DT   11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2006, sequence version 1.
DT   25-OCT-2017, entry version 91.
DE   SubName: Full=Non-ribosomal peptide synthase {ECO:0000313|EMBL:ABF91141.1};
GN   OrderedLocusNames=MXAN_3634 {ECO:0000313|EMBL:ABF91141.1};
OS   Myxococcus xanthus (strain DK 1622).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Myxococcaceae; Myxococcus.
OX   NCBI_TaxID=246197 {ECO:0000313|EMBL:ABF91141.1, ECO:0000313|Proteomes:UP000002402};
RN   [1] {ECO:0000313|EMBL:ABF91141.1, ECO:0000313|Proteomes:UP000002402}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DK 1622 {ECO:0000313|EMBL:ABF91141.1,
RC   ECO:0000313|Proteomes:UP000002402};
RX   PubMed=17015832; DOI=10.1073/pnas.0607335103;
RA   Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S.,
RA   Eisen J., Ronning C.M., Barbazuk W.B., Blanchard M., Field C.,
RA   Halling C., Hinkle G., Iartchuk O., Kim H.S., Mackenzie C., Madupu R.,
RA   Miller N., Shvartsbeyn A., Sullivan S.A., Vaudin M., Wiegand R.,
RA   Kaplan H.B.;
RT   "Evolution of sensory complexity recorded in a myxobacterial genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00258}.
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DR   EMBL; CP000113; ABF91141.1; -; Genomic_DNA.
DR   RefSeq; WP_011553652.1; NC_008095.1.
DR   ProteinModelPortal; Q1D6A2; -.
DR   STRING; 246197.MXAN_3634; -.
DR   PRIDE; Q1D6A2; -.
DR   EnsemblBacteria; ABF91141; ABF91141; MXAN_3634.
DR   KEGG; mxa:MXAN_3634; -.
DR   eggNOG; ENOG4105C0W; Bacteria.
DR   eggNOG; COG0318; LUCA.
DR   eggNOG; COG1020; LUCA.
DR   eggNOG; COG2141; LUCA.
DR   HOGENOM; HOG000229991; -.
DR   OMA; NRQHWNQ; -.
DR   OrthoDB; POG091H088I; -.
DR   BioCyc; MXAN246197:GIWU-3579-MONOMER; -.
DR   Proteomes; UP000002402; Chromosome.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   Gene3D; 1.10.1200.10; -; 5.
DR   Gene3D; 3.20.20.30; -; 1.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR024011; Biosynth_lucif-like_mOase_dom.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR011251; Luciferase-like_dom.
DR   InterPro; IPR036661; Luciferase-like_sf.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   Pfam; PF00501; AMP-binding; 6.
DR   Pfam; PF13193; AMP-binding_C; 4.
DR   Pfam; PF00296; Bac_luciferase; 1.
DR   Pfam; PF00668; Condensation; 5.
DR   Pfam; PF00550; PP-binding; 5.
DR   SMART; SM00823; PKS_PP; 5.
DR   SUPFAM; SSF47336; SSF47336; 5.
DR   SUPFAM; SSF51679; SSF51679; 1.
DR   TIGRFAMs; TIGR01733; AA-adenyl-dom; 3.
DR   TIGRFAMs; TIGR04020; seco_metab_LLM; 1.
DR   PROSITE; PS50075; ACP_DOMAIN; 5.
DR   PROSITE; PS00455; AMP_BINDING; 5.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002402};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002402}.
FT   DOMAIN      620    692       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     2039   2106       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     3099   3165       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     4577   4644       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     5635   5703       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   MOD_RES    5668   5668       O-(pantetheine 4'-phosphoryl)serine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00258}.
SQ   SEQUENCE   5741 AA;  623307 MW;  10253558FC1C20C9 CRC64;
     MLRVPPQRRS PAFPQLHPLE PLTMRSHPAA TLLELLETQT QSLGERRLYT FLEDGGDDAV
     LSYAGLDLRA RRIGAALQAL ARAGERAVLL YPPGLEYVAG FFGCLYAGLV AVPAYPPDPM
     RLERTLPRLR AIIRDARASV VLTTSFIQEM GEGLFEGAPE LAALRWVATD ALPEGTEAGW
     RRPEPSRDTL AFLQYTSGST GDPKGVQLSH GNLLHNLGLI SHAFQVRSDS VGVIWLPPYH
     DMGLIGGILQ PLYAGFPVAL MSPLAFLRRP RFWLESLSRF GGTISGGPCF AFDLCVRKVP
     PAEREGLDLR RWELAFCGAE PIRPEVMTRF SEAFAPVGFQ REALYPCYGL AEGTLIASGG
     RKGEGVLTRM WDAQALERNE ALAAEDGPGA RPLVGCGQTL PEQTLLVVDP ETRRACPPER
     VGEIWVSGPS VAHGYWERPE ESEAAFGARL ADSDSGPRFL RTGDLGLLKD GELFVVGRRK
     DLIILRGRNL HPQDLELTLE RSHSALRPGC GAAFSIDVGG EERLAVMYEV DSRKPWTAED
     VVGAVRRGLA ETHEVQLHTL VLIEPGALPK TSSGKIQRRA CRAELLAGTA RALLTWSESE
     ADAPQAKAPA PDITASQPLT VEALEAWLLA RIASRLRVRP EELATDAPIT SFGLDSLGAV
     ELANDVETLG VVLRMEVLLQ GPTVGALALT LFAARGASTG AELTRGEERT PAPLSSAQQR
     LWLFEQLAQG SAAYHLPAAV RLTGALDDVA LEHAFAAIVQ RHAALRATFR DEDGTPSQVT
     SSVPVSSLRR VDLRDVPVDA REEAALRLAH EEARAPFDLE RGPLLRATLF QLDAHEHLLV
     VVMHHIASDG ASFAILAREL SALYAGDVSL PPLAFQYPDF ARWRREVEAD GALATSLDWW
     KARLAGGAAA LELPADRSRP PMPSYRGGRV AVRFPEALTA RLEALGRSEG ATLFMTLLAA
     FEVLLARHSG QADFCVGTAV NGRERAGLEG LMGCFLDLIV LRASVSGSSR FRELLGQTRE
     GVLAAFAHRG VSFERLVDAV QPTRDPSRAP LFQVLFVLQP EPGAGLALPG LESRRVEVDP
     GATPYDLTLS LARGPEGLGG WLEYATDLFD ADTAARLVAR LGVLLESIVA DPDQRLAMLP
     LLPEAEQRQV LVDWNDTRAE FPEACIHALV ELQAQRTPDA VAVVCGDGVL TYRELNQRAN
     AVAWRLREQG VGPECIVGLF ADRSADLVVG LLGIFKAGGA YLPLDPSYPE ARLALMLEDS
     GASVVLAHRH LAGALPFGDR TVVPLDVAGE ADAAPPGAVG PDNLAYVLYT SGSTGKPKGV
     LIPHRNVVSF FTGMDARVGT EPGTWLAVTS VSFDISVLEL LWTLARGFKV AVQGEQGALG
     AAPRRVTRSR QKPLGFSLFY FAADEGAPGA ERYRLLLEGA RFADRHGFQA VWTPERHLHA
     FGGLYPNPSV TSAAIAAITE RVAIRAGSVV LPLHHPVRVA EEWSLVDNLS KGRVGISVAP
     GWHADDFVLA PERYAERREL ARRDLDTLRR LWRGESLSFP NGAGTPIDVR IRPSPVQREL
     PVWLTAAGNP DTFREAGRLG AGVLTHLLGQ RWEELESRIA LYREAWREAG HEGEGHVTLM
     LHTFVGHDVE RVRETVEAPL RRYLSNSADL MRGLGRTLGV DLDPASVRPE DLDALVGRAF
     GRFFDGAGLF GTPRTCREQV ARIEALGVDE VACLIDFGVD TDAVLASLPA LDAVRQRCER
     DFRLQSQEEI TVPAQLRRHG VTHLQCTPSL AQALLLEPGA AGALVGLERL LVGGEALSAE
     LAERLRGTMG GALLNMYGPT ETTIWSSSHA VDGSPGPVPI GTPIANTSLY VLDAELRPLP
     VGVPGELYIG GMGVARGYHA RPELTAERFL PDPASSNAGA RMYRTGDRAR WRADGTVEFL
     GRVDHQLKVR GFRVEPGEIE SVLARHSDVA QAVVVAREAS AGGARLVAYV VARPGTALSV
     EALLAFSRRS LPEHMVPSAF VPLDALPLTP NGKVDRKALP APEGVRDVAR EYVAPRTDTE
     RRLAELWASL LGVERVGAED DFFALGGHSL LATRAASRIR EAFGVDLPLR ELFESSSPAA
     LGARIDARLL GASGVPPLVA RSHEGALPLS FAQQRLWFLE QLEPGGAAYN DAVAVRVEGA
     LDVALLERSL REVVRRHEVL RATFHDDGGT PSWRIHPEAR LALDRVDLTA LSGADQAEAL
     SLRLAEESLR AFDLGAGPPL RATLLQVSAR EHVLLLVLHH LVTDGASMGV LVLEVAALYR
     AFSQGQVSPL SPLPLQYVDY AAWQRDWLRG EALEAQLAYW RTRLGGAPRA LDLPTDRPRP
     AVRSSRGVSR SMLLGPELSH ALKTLAQREG ATPFMVLLAG FSALLSRHGG QDDLCVGTPV
     EGRDRTELEG LIGCFVNTLV LRVSLAGTPS FRELIGRARE TVLGAFAHQD APFEELVKAL
     QPERDLGRSP LFQAMLVMQE DPLPELVIPG LRLNVQPQPS LTAKFDLRLI ITDTADGFSA
     NLELSTDLFE PDTATRLLEH LRVLLEAGVR EPEQQVHALP LMTSAERHRV LVAWNDTDRP
     RPGVSVLHRL IEARVDRTPD VVALSFESDT LTYRELDRRA NQLARYLRAR GVGPDTRVAL
     CVERSLEMVV GLLGVLKAGG AYVPLDPEYP RERLEYMLAD AAAPVLLTQA RLSERLPRDS
     ATVVCLDSEW DAVAREREER LDVTVDGSGL AYVLYTSGST GRPKGAMNTH AAICNRLLWM
     QEAYGLDSSD RVLQKTPFSF DVSVWEFFWP LLAGARLVMA RPGGHREPAY LTDTIARERI
     TTLHFVPSML RPFLEETELA VSCASLRRVF CSGEALPPEL RDRYFSCLLA ELHNLYGPTE
     AAVDVTAWAC AREDRGHVVP IGRPIANARM YVLDARLRPV PAGVPGELYI GGAPLARGYW
     QRPDLTAERF LPDAFAAQPG ARMYRTGDQA RFLANGAIEY LGRLDDQVKL RGFRIELGEI
     EAVLSLHPGV RAAAVAIRED VPGDRRLVAY VVAPSGDVAS ELRAFLGERL PEHMVPSAFV
     TLDALPLSPS GKLDRRGLPA PVRAVQGRGA AHVEPRNALE LEIAQIWAGV LGVERVGAED
     RFFELGGDSI LALQVIARAR QVGIHLTARQ LFQHPTVAGL AQVATSRRRL GDQGPVVGPV
     PLTPIQRWFV ERELPEAHHF NQALMLEPRE RLESDVLACA LRALVDHHDA LRLRLSRSDT
     GWAQSCAEPG RDVPLRLVDL SGLDAAARAV AMERTATEEQ AGLDLNAGCL LRAVLFDPGP
     NRRGRLLLVI HHLAADGVSW RVLLEDLETA LRQLARGEPV ALPAKTTSFQ AWARRLEVHA
     ASGVLAEEGA YWRDVLSADV AALPRDVPGG VNSQGSERVV TVALDADVTH SLLRASATMS
     QPGLEDVLLT GVASALARWS GERRLRIDLE GHGRDELFDD VDLSRTVGWF TALFPVRLEL
     PEGLASASVL ASVRAAREHR KGRGVGYGLL RYLRHDAGAS SEVLFNYLGQ LDSGTRDSAL
     FSLAPESTGA SQGTRGLRSH VLEVVARVVG GRLELAWHYS EALHSRARIE ALARHCVETL
     VELAGATEEC HALSPLQHGL LFQVLLEPGT GAYFEQRSWT LAGPLNAGAL RRAWEAVSER
     HSSLRTSFLW DGLEAPVQVV HARATPVWAE LDWRGRSSEE QSQSLAAFLR EDRAQGFVLS
     QAPLMRLALI RLEDHAWRFV WSFHHLLLDG WSLARVLGEV LDAYAAIAAG ADWLPPAASM
     DFRTYVEWLG RRRPEQDEAF WREQLEGIEA PTPLPAAGGS TAAHDTGEHA LDLGEADTAA
     LQEFARSHGL TPSTLVHGAW ALLLSRYGGG QDVMFATTLA GRPPELPGIE EAVGLFIHSL
     PVRARIQHGA GLLPWLSELQ SLLVELGQRE HVPLTRLQGW SDIPRGTPLF ESLLVFENYP
     VDAALVRGAS GLELRDFAAF ERTHYPLTAV VVPGRSMRLK LLYRQERISK VAAEQLLTHW
     RGLLQAMWSR PEQRLGDVSL LSEAERRRVL VEWNATATTY PREATVHSLF ESQAARAPET
     VAVRYGGTSL TYAELNAWAN QVARRLGALG VRRGTHVGLC VERSAELVVG MLGILKAGAA
     YVPLDPAYPR ERLAWMIADA GAPVLLTQER LRGAVPSEGV SVLTVEEVSA QGDVAETAAL
     GAGVGAADAA YVIYTSGSTG TPKGVCVSHQ AVVRLVVETD FIRVVPEDRV AQASNASFDA
     ATFEIWGALL NGARVVGVER ETALSPSAFA SWLREEGIRV LFLTTAWFNQ VAAEVPDAFS
     GLRQLHFGGE AVDPRPVRRV LREGAPERLL HVYGPTENTT FSTWHLVTDV PEGAVSIPIG
     RPLANTVQYV LDEDMAPVPP GGVGELWLGG DGLAWGYLGQ PALTAERFVP NPFSERPGTR
     LFRTGDRVRL LADGAVTFEG RVDAQVKVRG FRVEPGEVEA ALLRHPDVRQ AVVLAREDEA
     GGSRRLVAYV VPTAEAAATP EPSLLRTFLA AHLPAYMVPA AFMVLGRLPL TPNGKVDRRA
     LPAPTVESEV IAPRGPEEEL LAQLFGELLG VSRVGASDSF FDLGGHSLLA TRVVTRIHAT
     FGVALSLREL FDDPTVARLA GRIREARQSS GTARPPPIVP VSRDNPLPLS AMQERLWLLE
     QLQPGTALYN VPWAAWLAGP LDVPALERAL AGLFLRHEAL RTTFSSNAGE PVQIIHPSAN
     VALLVVDLEG LPEEAREAQA VIAASEEARR PFDLVNGPLC RALLIRTADD SHLLVLTLHH
     IVSDGWSLGV AVRELSALYA AELQGRPSSL PVPTIQPADH AVWQRQWMQG EALAAQVGYW
     RRQLAGAPPV LELPKDFPRP SLQRFRGDTL AVRFPAELSE AFRALCIREG VTPFMGLLAA
     FQLLLSRVSG QEDVCVGSPI AGRQQPGLEN LIGFFVNTLV LRARLPRSSS FRELLRQVRE
     TTLDAYAHQD VPFEKLVEAL QPPRSLSHAP LVQVVLALHE ASRQDVAPQG LALRPVELAS
     GTAKFDLTLS LTDAAEGFTG TLEFDADLFT RETAARLMKG LRVLLESAVA DAGQRLGELP
     MMDSADRQRL LVAWNDTAVE YPREACLAEL FEAQAARSPE AVAVVCEEAR LTYAELDRRA
     NQLAWYLRNR GVGPGTPVGL CVQRSLDLVV GMLGILKAGG AYVPLDPTYP RERLAFMVED
     TRLPVVLAQQ SVVALLPSGS ADVVLLDSAW DEIAREPTVS PRVTVPAESL AYVMYTSGST
     GRPKGVCVPQ RAVARLVLGS RFARWGADEV FLQLAPICFD AATFEVWGAL LHGAKLVLFP
     AQPPTVDTLK DVLARHGVTT LWLTAALFEA LSAARPDALD GVRQLLAGGD VLPPAAVRER
     LGRGGILVNG YGPTEGTTFT CCHVMEGAVA PGAIPIGRPI ANTRVYVVDA ALRPVPVGVP
     GELLIGGDGL AWGYQGRPEL TAERFVPNPF GSEAGGRLYR TGDSVRYRED GTLEFLERLD
     GQVKVRGYRV EPGEVEEALR LHPSVAEAVV VARPDPAGGK RLVAYAVPRA GETLDPRGLR
     GFLAESLPEF MVPSTLVPLM ALPLTPVGKL DRRALPEPEV SRPAGSAFVE PTTALERQVA
     ALWAKVLGVE RVGVEDHFFA DLGGSSMSVV KACALLRDEL KRDVPATRFF EHPTVRAFVM
     SLERDGETAA DTQDNEAHVD RAQQRRQAIR RQGRRGNHGN G
//
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