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Database: UniProt/TrEMBL
Entry: Q29JH1_DROPS
LinkDB: Q29JH1_DROPS
Original site: Q29JH1_DROPS 
ID   Q29JH1_DROPS            Unreviewed;      1295 AA.
AC   Q29JH1;
DT   04-APR-2006, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2008, sequence version 2.
DT   30-AUG-2017, entry version 72.
DE   RecName: Full=Histone deacetylase {ECO:0000256|SAAS:SAAS00818223};
DE            EC=3.5.1.98 {ECO:0000256|SAAS:SAAS00818223};
GN   Name=Dpse\GA14617 {ECO:0000313|EMBL:EAL32330.2};
GN   ORFNames=Dpse_GA14617 {ECO:0000313|EMBL:EAL32330.2}, GA14617
GN   {ECO:0000313|FlyBase:FBgn0074644};
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245 {ECO:0000313|EMBL:EAL32330.2, ECO:0000313|Proteomes:UP000001819};
RN   [1] {ECO:0000313|EMBL:EAL32330.2, ECO:0000313|Proteomes:UP000001819}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94
RC   {ECO:0000313|Proteomes:UP000001819};
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P.,
RA   Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J.,
RA   van Batenburg M.F., Howells S.L., Scherer S.E., Sodergren E.,
RA   Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D.,
RA   Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D.,
RA   Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R.,
RA   Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L.,
RA   Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura:
RT   chromosomal, gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
RN   [2] {ECO:0000313|EMBL:EAL32330.2, ECO:0000313|Proteomes:UP000001819}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94
RC   {ECO:0000313|Proteomes:UP000001819};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of
CC       a histone to yield a deacetylated histone.
CC       {ECO:0000256|SAAS:SAAS00818219}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00818221}.
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DR   EMBL; CH379063; EAL32330.2; -; Genomic_DNA.
DR   RefSeq; XP_001355273.2; XM_001355237.3.
DR   ProteinModelPortal; Q29JH1; -.
DR   STRING; 7237.FBpp0273105; -.
DR   EnsemblMetazoa; FBtr0274667; FBpp0273105; FBgn0074644.
DR   GeneID; 4815727; -.
DR   KEGG; dpo:Dpse_GA14617; -.
DR   FlyBase; FBgn0074644; Dpse\GA14617.
DR   InParanoid; Q29JH1; -.
DR   KO; K11406; -.
DR   OMA; KCENEEA; -.
DR   Proteomes; UP000001819; Partially assembled WGS sequence.
DR   Bgee; FBgn0074644; -.
DR   GO; GO:0000118; C:histone deacetylase complex; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:UniProtKB-EC.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.800.20; -; 1.
DR   InterPro; IPR033660; HDAC4.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR017320; Histone_deAcase_II_euk.
DR   PANTHER; PTHR10625; PTHR10625; 1.
DR   PANTHER; PTHR10625:SF158; PTHR10625:SF158; 1.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PIRSF; PIRSF037911; HDAC_II_euk; 4.
DR   PRINTS; PR01270; HDASUPER.
PE   4: Predicted;
KW   Chromatin regulator {ECO:0000256|SAAS:SAAS00818226};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001819};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00490343,
KW   ECO:0000313|EMBL:EAL32330.2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR037911-2};
KW   Nucleus {ECO:0000256|SAAS:SAAS00818233};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001819};
KW   Transcription {ECO:0000256|SAAS:SAAS00818215};
KW   Transcription regulation {ECO:0000256|SAAS:SAAS00818213};
KW   Zinc {ECO:0000256|PIRSR:PIRSR037911-2}.
FT   DOMAIN      886   1200       Hist_deacetyl. {ECO:0000259|Pfam:
FT                                PF00850}.
FT   ACT_SITE   1011   1011       {ECO:0000256|PIRSR:PIRSR037911-1}.
FT   METAL       878    878       Zinc. {ECO:0000256|PIRSR:PIRSR037911-2}.
FT   METAL       880    880       Zinc. {ECO:0000256|PIRSR:PIRSR037911-2}.
FT   METAL       886    886       Zinc. {ECO:0000256|PIRSR:PIRSR037911-2}.
FT   METAL       959    959       Zinc. {ECO:0000256|PIRSR:PIRSR037911-2}.
SQ   SEQUENCE   1295 AA;  140204 MW;  747F7E9BAC8F5DED CRC64;
     MSSPDDRIPI HDLPPEAGSD ERLLHIGPVP LTLDFKPHPA VDIDQQIMEL KKNQELQKQR
     LIHSFQEKSK QMELEHKLQL EHKYQFAVHS HGAFQELREQ TMVTAAAAAA AAVVEEHHRQ
     QQQQQQHHHH HHHQQQQQQQ QQQQQQHHHQ QQREQQQQRE RREREVMKRK ENCSANASPE
     VKQILNCFIM SRKSQAAASN GTTTTSPYRN RGVVKSSSGE SLPAGTVTSA HPYKIPQPPS
     SLLKYESDFP LRKTASEPNL LKIRLKQSVI ERKARNGGPA GARRHERLLQ AAQRRQQKNS
     VLTNSNSTPD SGPNSPPSST GLSVGVVGSR GSPTSAPIQE ENEEGSQYQP GQRSSINDLP
     LFSSPSLPNI SLGRPHLPNS AQVQAQAQAQ AQAQAQASAQ AQAQAQARAT AMFAALHQHV
     AAAGGQPTYY NQLGMSFVGR QPTGPLAMMP ATGIAPQQPS PVVRSASATS TSSSQASLVG
     DVAPPQAHAA STILPSSSSY MQQLGGVTAG SAVNLHAAAV AAAAAAAAAA AGSLPPTNSH
     GHGHGYGHGH GHGHGHGHGH GHALYGGHPH NTPITDAQVA QVHLHKQGHR PLGRTQSAPL
     PLGHPMLTGA GQLNVAQTHY ENSEAERQAY QHQVLTQKLR QTVLTRSGAA TAAGVRESQL
     KEEEDDSAAE VMDLTDKKKP PKTVLTSTIA TSTSQSLPEA LAAAAAVYRT SPSAATTPSA
     AVAGGSGTKV NSLQRDQEYL QQQRELLLLQ NKEELAKRLM RPLSRTLSSP LVPLGPHGLS
     QLADTGQGQG QQLPPIATSS SADHIPPVNL TLPHRQHRQF MNHFYTANLQ HQRQQQQQQQ
     QQQQEQQHLQ QTPPSASLPP HKITTGLAYD PLMLKHSCIC GDNAQHPEHS GRLQSVWARL
     NETDLVKRCD RLRARKATQE ELQTVHTEAH AMLFGSNQCQ LTRPKLETTL AASFVRLSCG
     GLGVDLDTTW NEHHTATAAR MAAGCVIDLA FKTAKGDLRN GFAVVRPPGH HAEANLAMGF
     CFFNSIAIAA KRLRQQMPEM RRILIVDWDV HHGNGTQQAF YQSPDILYLS IHRHDDGNFF
     PGTGGPTECG SGAGLGFNVN ISWSGALNPP LGDAEYIAAF RTVVMPIAKG FNPDIVLVSS
     GFDAATGHPA PLGGYHVSPA CFGFMTRELL QLANGKVVLA LEGGYDLAAI CDSAQECVRA
     LLGDPAAPIS QSELERPPCQ NAINTLQKTI AIQQTHWPCV RMLEHTVGLS ALETLKVEHE
     ESETINAMAG LSMQSMHRTL SRDDSEEPMD QDETK
//
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