ID Q2FDQ9_STAA3 Unreviewed; 286 AA.
AC Q2FDQ9;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 01-MAY-2013, entry version 53.
DE RecName: Full=2-dehydropantoate 2-reductase;
DE EC=1.1.1.169;
GN Name=panE; OrderedLocusNames=SAUSA300_2535;
OS Staphylococcus aureus (strain USA300).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcus.
OX NCBI_TaxID=367830;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=USA300;
RX PubMed=16517273; DOI=10.1016/S0140-6736(06)68231-7;
RA Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA Perdreau-Remington F.;
RT "Complete genome sequence of USA300, an epidemic clone of community-
RT acquired meticillin-resistant Staphylococcus aureus.";
RL Lancet 367:731-739(2006).
CC -!- FUNCTION: Catalyzes the NADPH-dependent reduction of ketopantoate
CC into pantoic acid (By similarity).
CC -!- CATALYTIC ACTIVITY: (R)-pantoate + NADP(+) = 2-dehydropantoate +
CC NADPH.
CC -!- SIMILARITY: Belongs to the ketopantoate reductase family.
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DR EMBL; CP000255; ABD20450.1; -; Genomic_DNA.
DR RefSeq; YP_495169.1; NC_007793.1.
DR ProteinModelPortal; Q2FDQ9; -.
DR STRING; 451515.SAUSA300_2535; -.
DR EnsemblBacteria; ABD20450; ABD20450; SAUSA300_2535.
DR GeneID; 3913849; -.
DR KEGG; saa:SAUSA300_2535; -.
DR PATRIC; 19594673; VBIStaAur129981_2712.
DR HOGENOM; HOG000280297; -.
DR KO; K00077; -.
DR OMA; SKNICKL; -.
DR ProtClustDB; PRK12921; -.
DR BioCyc; SAUR451515:GH3C-2535-MONOMER; -.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:EC.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0015940; P:pantothenate biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1040.10; -; 1.
DR Gene3D; 3.40.50.720; -; 1.
DR InterPro; IPR008927; 6-PGluconate_DH_C-like.
DR InterPro; IPR003710; ApbA.
DR InterPro; IPR013752; ApbA_C.
DR InterPro; IPR013332; ApbA_N.
DR InterPro; IPR013328; DH_multihelical.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6DGDH_C_like; 1.
DR TIGRFAMs; TIGR00745; apbA_panE; 1.
PE 3: Inferred from homology;
KW Complete proteome; NADP; Oxidoreductase; Pantothenate biosynthesis.
SQ SEQUENCE 286 AA; 32358 MW; 833DB4AD9F5AF254 CRC64;
MLSVAIIGPG AVGTTIAYEL QQSLPHTTLI GRHAKTITYY TVPHAPAQDI VVKGYEDVTN
TFDVIIIAVK THQLDAVIPH LTHLAHEDTL IILAQNGYGQ LEHISFKNVC QAVVYISGQK
KGDVVTHFRD YQLRIQDNAL TRQFRDLVQD SQIDIVLEAN IQQAIWYKLL VNLGINSITA
LGRQTVAIMH NPEIRTLCRQ LLLDGCRVAQ AEGLNFSEQT VDTIMTIYQG YPDEMGTSMY
YDIAHQQPLE VEAIQGFIYR RAREHNLDTP YLDTIYSFLR AYQQNM
//
