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Database: UniProt/TrEMBL
Entry: Q2T9Y5_BOVIN
LinkDB: Q2T9Y5_BOVIN
Original site: Q2T9Y5_BOVIN 
ID   Q2T9Y5_BOVIN            Unreviewed;       943 AA.
AC   Q2T9Y5;
DT   24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT   24-JAN-2006, sequence version 1.
DT   25-OCT-2017, entry version 79.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   Name=LIG3 {ECO:0000313|EMBL:AAI11208.1};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI11208.1};
RN   [1] {ECO:0000313|EMBL:AAI11208.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Crossbred x Angus {ECO:0000313|EMBL:AAI11208.1};
RC   TISSUE=Liver {ECO:0000313|EMBL:AAI11208.1};
RA   Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA   Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA   Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA   Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA   Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D.,
RA   Siddiqui A., Holt R., Jones S.J., Marra M.A.;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; BC111207; AAI11208.1; -; mRNA.
DR   RefSeq; NP_001033196.1; NM_001038107.2.
DR   UniGene; Bt.25483; -.
DR   ProteinModelPortal; Q2T9Y5; -.
DR   PaxDb; Q2T9Y5; -.
DR   PRIDE; Q2T9Y5; -.
DR   GeneID; 514719; -.
DR   KEGG; bta:514719; -.
DR   CTD; 3980; -.
DR   eggNOG; KOG4437; Eukaryota.
DR   eggNOG; COG1793; LUCA.
DR   HOGENOM; HOG000007653; -.
DR   HOVERGEN; HBG005515; -.
DR   KO; K10776; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.30.1740.10; -; 1.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR001510; Znf_PARP.
DR   InterPro; IPR036957; Znf_PARP_sf.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   Pfam; PF00645; zf-PARP; 1.
DR   SMART; SM01336; zf-PARP; 1.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
DR   PROSITE; PS00347; PARP_ZN_FINGER_1; 1.
DR   PROSITE; PS50064; PARP_ZN_FINGER_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617, ECO:0000313|EMBL:AAI11208.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617}.
FT   DOMAIN       92    184       PARP-type. {ECO:0000259|PROSITE:PS50064}.
FT   DOMAIN      585    719       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
SQ   SEQUENCE   943 AA;  105101 MW;  05873FA748DA489F CRC64;
     MTLAFKILFP PTLRVLRKKE LCLFREHRRP DIRHFGRWSE TVFCGYHLLQ RRKPVPSFQE
     SNLKLRATCL VYLPGSHVGL CSGPCEMAEQ RFCVDYAKRG TAGCKKCKEK IVKGVCRIGK
     VVPNPFSESG GDMKEWYHIK CMFEKQERAP ATTKKIEDLT ELEGWEELEE NEKEQISQHI
     ADLSSKATST PKKKAVVQAK LTATGQVASP VKGASFVTNS NPRKFSGFSA KPNNSGEAHS
     SPTPKTPKTS MSSSKCDPKH KDCLLREFRK LCAMVAENPS YNTKTQIIQD FLQKGSAGDG
     FHGDVYLTVK LLLPGVIKSV YNLNDKQIVK LFSRIFNCNS DDMTRDLEQG DVSETIRVFF
     EQSKSFPPAA KSLLTIQEVD EFLLRLSKLT KEDEQQQALQ DIASRCTAND LKCIIRLIKH
     DLKMNSGAKH VLDALDPNAY EAFKASRNLQ DVVERVLRNE QEVEKEPGQR RALSVQASLM
     TPVQPMLAEA CKSIEYAMKK CPNGMFSEIK YDGERVQVHK KGDHFSYFSR SLKPVLPHKV
     AHFKDFIPRA FPGGHSMILD SEVLLVDNRT GKPLPFGTLG VHKKAAFQDA NVCQFVFDCI
     YFNDVSLMDR PLCERRKLLH DNMVEIPNRI MFSEMKQVTK ASDLVDMINR VIQEGLEGLV
     LKDVKGTYEP GKRHWLKVKK DYLNEGAMAD TADLVVLGAF YGQGSKGGMM SIFLMGCYDP
     SSQKWCTVTK CAGGHDDATL ARLQTELDMV KISKDPSKIP NWLKINKIYY PDFIVPDPKK
     AAVWEITGAE FSKSEAHTAD GISIRFPRCT RIRDDKDWKS ATTLPQLKEL YQLSKERAAF
     AITAGDEGSS ATGGSSGENE GTSGPAVPHK APRASPKQPP TSAKKAGGKP GGCTSRGGNL
     PAAEPSPVRA GVKRKAPDVT PCQAKRRPAS KRRGRRAVPT GRR
//
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