ID Q31L56_SYNE7 Unreviewed; 259 AA.
AC Q31L56;
DT 06-DEC-2005, integrated into UniProtKB/TrEMBL.
DT 06-DEC-2005, sequence version 1.
DT 01-MAY-2013, entry version 51.
DE RecName: Full=Ribonuclease H;
DE Short=RNase H;
DE EC=3.1.26.4;
GN Name=rnhA; OrderedLocusNames=Synpcc7942_2183;
OS Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2).
OC Bacteria; Cyanobacteria; Oscillatoriophycideae; Chroococcales;
OC Synechococcus.
OX NCBI_TaxID=1140;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7942;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M.,
RA Kyrpides N., Lykidis A., Richardson P.;
RT "Complete sequence of chromosome 1 of Synechococcus elongatus PCC
RT 7942.";
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Endonuclease that specifically degrades the RNA of RNA-
CC DNA hybrids (By similarity).
CC -!- CATALYTIC ACTIVITY: Endonucleolytic cleavage to 5'-
CC phosphomonoester.
CC -!- COFACTOR: Binds 1 magnesium ion per subunit. May bind a second
CC metal ion at a regulatory site, or after substrate binding (By
CC similarity).
CC -!- SUBUNIT: Monomer (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the RNase H family.
CC -!- SIMILARITY: Contains 1 RNase H domain.
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DR EMBL; CP000100; ABB58213.1; -; Genomic_DNA.
DR RefSeq; YP_401200.1; NC_007604.1.
DR ProteinModelPortal; Q31L56; -.
DR STRING; 1140.Synpcc7942_2183; -.
DR EnsemblBacteria; ABB58213; ABB58213; Synpcc7942_2183.
DR GeneID; 3773740; -.
DR KEGG; syf:Synpcc7942_2183; -.
DR PATRIC; 23789875; VBISynElo51371_2458.
DR eggNOG; COG0328; -.
DR HOGENOM; HOG000040465; -.
DR KO; K03469; -.
DR ProtClustDB; CLSK895212; -.
DR BioCyc; SELO1140:GJWQ-2215-MONOMER; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:ribonuclease H activity; IEA:HAMAP.
DR GO; GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
DR GO; GO:0006401; P:RNA catabolic process; IEA:HAMAP.
DR HAMAP; MF_00042; RNase_H; 1; -.
DR InterPro; IPR022892; RNaseH.
DR InterPro; IPR012337; RNaseH-like_dom.
DR InterPro; IPR002156; RNaseH_domain.
DR Pfam; PF00075; RNase_H; 1.
DR SUPFAM; SSF53098; RNaseH_fold; 1.
DR PROSITE; PS50879; RNASE_H; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Endonuclease; Hydrolase; Magnesium;
KW Metal-binding; Nuclease.
FT DOMAIN 2 146 RNase H (By similarity).
FT METAL 11 11 Magnesium 1 (By similarity).
FT METAL 11 11 Magnesium 2 (By similarity).
FT METAL 50 50 Magnesium 1 (By similarity).
FT METAL 75 75 Magnesium 1 (By similarity).
FT METAL 138 138 Magnesium 2 (By similarity).
SQ SEQUENCE 259 AA; 29448 MW; 1CA9C8DAD87C16D9 CRC64;
MSDAILRLYT DGACTGNPGP GGWGVQIQFA DGTVQELGGR DAATTNNRME LQAAIAALEF
WRDHSDQQPV TLYTDSEYVI KGITQWLKGW QRKGWKTAAG KPVLNQDLWM HLDDLNSPAV
QWQYVRGHSG DPGNERCDQI ARSFAQQRPL PLCQRSDAPL QSGQPQQEPV RMPEVVTQEW
SSNPRDRSQR LRDVLDCLQI AAAIAEQQFL ITSSELADLM DVNASAVTSR GEEWIWRNWR
VKRDRREGNQ ILWQLERIH
//
