ID Q334G8_CHICK Unreviewed; 358 AA.
AC Q334G8;
DT 06-DEC-2005, integrated into UniProtKB/TrEMBL.
DT 06-DEC-2005, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE RecName: Full=C-X-C chemokine receptor type 2 {ECO:0000256|ARBA:ARBA00020033};
DE AltName: Full=High affinity interleukin-8 receptor B {ECO:0000256|ARBA:ARBA00033468};
GN Name=CXCR1 {ECO:0000313|EMBL:CAJ00346.1,
GN ECO:0000313|Ensembl:ENSGALP00010027702.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:CAJ00346.1};
RN [1] {ECO:0000313|EMBL:CAJ00346.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Line 7 {ECO:0000313|EMBL:CAJ00345.1}, Line C
RC {ECO:0000313|EMBL:CAJ00347.1}, and Line N
RC {ECO:0000313|EMBL:CAJ00346.1};
RC TISSUE=Spleen {ECO:0000313|EMBL:CAJ00345.1};
RX PubMed=18417470; DOI=10.1074/jbc.M800998200;
RA Poh T.Y., Pease J., Young J.R., Bumstead N., Kaiser P.;
RT "Re-evaluation of Chicken CXCR1 Determines the True Gene Structure CXCLi1
RT (K60) AND CXCLi2 (CAF/INTERLEUKIN-8) ARE LIGANDS FOR THIS RECEPTOR.";
RL J. Biol. Chem. 283:16408-16415(2008).
RN [2] {ECO:0000313|Ensembl:ENSGALP00010027702.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010027702.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ973196; CAJ00345.1; -; mRNA.
DR EMBL; AJ973197; CAJ00346.1; -; Genomic_DNA.
DR EMBL; AJ973198; CAJ00347.1; -; mRNA.
DR RefSeq; NP_001269361.1; NM_001282432.1.
DR RefSeq; XP_015145344.1; XM_015289858.1.
DR STRING; 9031.ENSGALP00000054150; -.
DR Ensembl; ENSGALT00010046530.1; ENSGALP00010027702.1; ENSGALG00010019250.1.
DR Ensembl; ENSGALT00010046535.1; ENSGALP00010027706.1; ENSGALG00010019250.1.
DR Ensembl; ENSGALT00010046539.1; ENSGALP00010027709.1; ENSGALG00010019250.1.
DR GeneID; 430652; -.
DR KEGG; gga:430652; -.
DR CTD; 3577; -.
DR VEuPathDB; HostDB:geneid_430652; -.
DR GeneTree; ENSGT01050000244848; -.
DR OMA; VCSVVWL; -.
DR OrthoDB; 5347598at2759; -.
DR Reactome; R-GGA-380108; Chemokine receptors bind chemokines.
DR Reactome; R-GGA-418594; G alpha (i) signalling events.
DR Reactome; R-GGA-6798695; Neutrophil degranulation.
DR Proteomes; UP000000539; Chromosome 7.
DR Bgee; ENSGALG00000036627; Expressed in granulocyte and 7 other cell types or tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0019957; F:C-C chemokine binding; IBA:GO_Central.
DR GO; GO:0016493; F:C-C chemokine receptor activity; IBA:GO_Central.
DR GO; GO:0016494; F:C-X-C chemokine receptor activity; IEA:InterPro.
DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR CDD; cd15178; 7tmA_CXCR1_2; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000174; Chemokine_CXCR_1/2.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR10489:SF689; C-X-C CHEMOKINE RECEPTOR TYPE 2; 1.
DR PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00427; INTRLEUKIN8R.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Chemotaxis {ECO:0000256|ARBA:ARBA00022500};
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|RuleBase:RU000688, ECO:0000313|EMBL:CAJ00346.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 48..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 83..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 128..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 63..313
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 358 AA; 40271 MW; 6C8442218557FF7F CRC64;
MGTFYADELL DILYNYTSDY GNYSLVLPDI DVSSSPCRNE GSVANKYLVA FIYCLVFLLS
MVGNGLVVLV VTSGHINRSV TDVYLLNLAV ADLLFALSLP LWAVYWAHEW VFGTVMCKAI
SVLQESNFYS GILLLACISV DRYLAIVYAT RAATEKRHWV KFVCVGIWVF SVLLSLPVLL
FREAFVSDRN GTVCYERIGN ENTTKWRVVL RVLPQTFGFA LPLLVMLFCY GVTVHTLLQT
KNVQKQRAMK VILAVVLVFL VCWLPYNITL VSDTLMRTRA ITETCERRKH IDTALSITQV
LGFAHSCINP IIYAFIGQKF RNSFLKILAQ RGFISKDAVA RYGRTSYTST SGNTSTTL
//