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Database: UniProt/TrEMBL
Entry: Q3Z895_DEHE1
LinkDB: Q3Z895_DEHE1
Original site: Q3Z895_DEHE1 
ID   Q3Z895_DEHE1            Unreviewed;       166 AA.
AC   Q3Z895;
DT   27-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2005, sequence version 1.
DT   19-FEB-2014, entry version 53.
DE   RecName: Full=3-isopropylmalate dehydratase small subunit;
DE            EC=4.2.1.33;
DE   AltName: Full=Alpha-IPM isomerase;
DE   AltName: Full=Isopropylmalate isomerase;
GN   Name=leuD; OrderedLocusNames=DET0827;
OS   Dehalococcoides ethenogenes (strain 195).
OC   Bacteria; Chloroflexi; Dehalococcoidia; Dehalococcoidales;
OC   Dehalococcoidaceae; Dehalococcoides.
OX   NCBI_TaxID=243164;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=195;
RX   PubMed=15637277; DOI=10.1126/science.1102226;
RA   Seshadri R., Adrian L., Fouts D.E., Eisen J.A., Phillippy A.M.,
RA   Methe B.A., Ward N.L., Nelson W.C., DeBoy R.T., Khouri H.M.,
RA   Kolonay J.F., Dodson R.J., Daugherty S.C., Brinkac L.M.,
RA   Sullivan S.A., Madupu R., Nelson K.E., Kang K.H., Impraim M., Tran K.,
RA   Robinson J.M., Forberger H.A., Fraser C.M., Zinder S.H.,
RA   Heidelberg J.F.;
RT   "Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides
RT   ethenogenes.";
RL   Science 307:105-108(2005).
CC   -!- FUNCTION: Catalyzes the isomerization between 2-isopropylmalate
CC       and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: (2R,3S)-3-isopropylmalate = (2S)-2-
CC       isopropylmalate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-leucine biosynthesis; L-
CC       leucine from 3-methyl-2-oxobutanoate: step 2/4.
CC   -!- SUBUNIT: Heterodimer of LeuC and LeuD (By similarity).
CC   -!- SIMILARITY: Belongs to the LeuD family. LeuD type 2 subfamily.
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DR   EMBL; CP000027; AAW39938.1; -; Genomic_DNA.
DR   RefSeq; YP_181554.1; NC_002936.3.
DR   ProteinModelPortal; Q3Z895; -.
DR   STRING; 243164.DET0827; -.
DR   EnsemblBacteria; AAW39938; AAW39938; DET0827.
DR   GeneID; 3229900; -.
DR   KEGG; det:DET0827; -.
DR   PATRIC; 21608713; VBIDehEth89364_0785.
DR   eggNOG; COG0066; -.
DR   HOGENOM; HOG000222940; -.
DR   KO; K01704; -.
DR   OMA; GFVIPYE; -.
DR   OrthoDB; EOG6PZXB8; -.
DR   ProtClustDB; PRK00439; -.
DR   BioCyc; DETH243164:GJNF-828-MONOMER; -.
DR   UniPathway; UPA00048; UER00071.
DR   GO; GO:0009316; C:3-isopropylmalate dehydratase complex; IEA:InterPro.
DR   GO; GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.20.19.10; -; 1.
DR   HAMAP; MF_01032; LeuD_type2; 1.
DR   InterPro; IPR015937; Acoase/IPM_deHydtase.
DR   InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR   InterPro; IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
DR   InterPro; IPR011827; IsopropMal_deHydtase_ssu.
DR   InterPro; IPR011824; IsopropMal_deHydtase_ssu_bac.
DR   PANTHER; PTHR11670; PTHR11670; 1.
DR   Pfam; PF00694; Aconitase_C; 1.
DR   SUPFAM; SSF52016; SSF52016; 1.
DR   TIGRFAMs; TIGR02084; leud; 1.
DR   TIGRFAMs; TIGR02087; LEUD_arch; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Branched-chain amino acid biosynthesis;
KW   Complete proteome; Leucine biosynthesis; Lyase.
SQ   SEQUENCE   166 AA;  17967 MW;  17FC9FB547C63611 CRC64;
     MLKGFVHKYG ENVDTDAIIP ARYLNVSEPK ALAEHCMEDI DLDFVKKVKP GDFIVATTNF
     GCGSSREHAP ISIKASGVSA VIAASFARIF FRNAINIGLP LLESAEAAEK INSGDELEID
     LESGVIKDLT TGKSFAAKPY PEFMSRLIKA GGLIEYTREK LCGRGV
//
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