ID Q4D5B7_TRYCC Unreviewed; 572 AA.
AC Q4D5B7;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=PhoD-like phosphatase metallophosphatase domain-containing protein {ECO:0000259|Pfam:PF09423};
GN ORFNames=Tc00.1047053509803.30 {ECO:0000313|EMBL:EAN87718.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN87718.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN87718.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN87718.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN87718.1}.
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DR EMBL; AAHK01000991; EAN87718.1; -; Genomic_DNA.
DR RefSeq; XP_809569.1; XM_804476.1.
DR AlphaFoldDB; Q4D5B7; -.
DR STRING; 353153.Q4D5B7; -.
DR PaxDb; 353153-Q4D5B7; -.
DR EnsemblProtists; EAN87718; EAN87718; Tc00.1047053509803.30.
DR GeneID; 3540197; -.
DR KEGG; tcr:509803.30; -.
DR eggNOG; ENOG502QTGZ; Eukaryota.
DR InParanoid; Q4D5B7; -.
DR OMA; HAESHAM; -.
DR OrthoDB; 147576at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd07389; MPP_PhoD; 1.
DR Gene3D; 3.60.21.70; PhoD-like phosphatase; 1.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR018946; PhoD-like_MPP.
DR InterPro; IPR038607; PhoD-like_sf.
DR PANTHER; PTHR33987; CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN; 1.
DR PANTHER; PTHR33987:SF1; CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN; 1.
DR Pfam; PF09423; PhoD; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..37
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 38..572
FT /note="PhoD-like phosphatase metallophosphatase domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004236637"
FT TRANSMEM 532..559
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 90..420
FT /note="PhoD-like phosphatase metallophosphatase"
FT /evidence="ECO:0000259|Pfam:PF09423"
SQ SEQUENCE 572 AA; 63655 MW; 8A10A57624D23A4D CRC64;
MQIVMSDEKK SATTAAWAAP LLCFLFMILS IGTVAAAQEG SHELAQIVFV SCNQHDRDQN
YWDVIAATVE HGKDAGQLNK PLKRATGSCA ANSSVDALVW LGDAVYADNF SAFRGCYPNT
DLELVRSKFT KQRNAPEYVA FRQTCVRQRP TLAFREDGEE TQFVMGVWDD HDMGKNDGGA
EYADKDATQQ FFLDFLGVAK NSPRRKQKGV YVFETIPFRA LDSNASVNPA KSAAIKELHS
LYDHAVCFLL LDARYFREPS NATRSGDMLG EVQWKWLEER LRNDVAGQNP VSGRERCALT
IVGSGVQVIM DEKVSESWGA FPLSRNRLFL LLRRYKSERV IFISGDVHLG EIGMDTTQDA
MEALGYPILE ATSSGLTHSS ATFWGLPTLM RTLFPSPRRV GIYIERNFGV VRLTADPEAL
IMALKRDGKA QRHQFERYIN VSVFIHSIPQ QGKAVLQLSL PLDVFTIDGG GGTKGRFTTL
TSAVKRTCEN PSKENTENGD CSPAYYPRSA PLPVFTSLIQ FLQRHIWPQH TLLQVVSTVV
STSVLLLLAA TAVFCIRLWN TGSKGKKREK IS
//
