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Database: UniProt/TrEMBL
Entry: Q4DD33_TRYCC
LinkDB: Q4DD33_TRYCC
Original site: Q4DD33_TRYCC 
ID   Q4DD33_TRYCC            Unreviewed;       477 AA.
AC   Q4DD33;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   14-MAY-2014, entry version 57.
DE   RecName: Full=Dihydrolipoyl dehydrogenase;
DE            EC=1.8.1.4;
GN   ORFNames=Tc00.1047053511025.110;
OS   Trypanosoma cruzi (strain CL Brener).
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Trypanosoma;
OC   Schizotrypanum.
OX   NCBI_TaxID=353153;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CL Brener;
RX   PubMed=16020725; DOI=10.1126/science.1112631;
RA   El-Sayed N.M.A., Myler P.J., Bartholomeu D.C., Nilsson D.,
RA   Aggarwal G., Tran A.-N., Ghedin E., Worthey E.A., Delcher A.L.,
RA   Blandin G., Westenberger S.J., Caler E., Cerqueira G.C., Branche C.,
RA   Haas B., Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E.,
RA   Bringaud F., Burton P., Cadag E., Campbell D.A., Carrington M.,
RA   Crabtree J., Darban H., da Silveira J.F., de Jong P., Edwards K.,
RA   Englund P.T., Fazelina G., Feldblyum T., Ferella M., Frasch A.C.,
RA   Gull K., Horn D., Hou L., Huang Y., Kindlund E., Klingbeil M.,
RA   Kluge S., Koo H., Lacerda D., Levin M.J., Lorenzi H., Louie T.,
RA   Machado C.R., McCulloch R., McKenna A., Mizuno Y., Mottram J.C.,
RA   Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M., Pentony M.,
RA   Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA   Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J.,
RA   Simpson A.J., Sisk E., Tammi M.T., Tarleton R., Teixeira S.,
RA   Van Aken S., Vogt C., Ward P.N., Wickstead B., Wortman J., White O.,
RA   Fraser C.M., Stuart K.D., Andersson B.;
RT   "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT   disease.";
RL   Science 309:409-415(2005).
CC   -!- CATALYTIC ACTIVITY: Protein N(6)-(dihydrolipoyl)lysine + NAD(+) =
CC       protein N(6)-(lipoyl)lysine + NADH.
CC   -!- COFACTOR: Binds 1 FAD per subunit (By similarity).
CC   -!- MISCELLANEOUS: The active site is a redox-active disulfide bond
CC       (By similarity).
CC   -!- SIMILARITY: Belongs to the class-I pyridine nucleotide-disulfide
CC       oxidoreductase family.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data.
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DR   EMBL; AAHK01000630; EAN90443.1; -; Genomic_DNA.
DR   RefSeq; XP_812294.1; XM_807201.1.
DR   ProteinModelPortal; Q4DD33; -.
DR   SMR; Q4DD33; 10-476.
DR   GeneID; 3543432; -.
DR   KEGG; tcr:511025.110; -.
DR   KO; K00382; -.
DR   GO; GO:0004148; F:dihydrolipoyl dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR   Gene3D; 3.30.390.30; -; 1.
DR   InterPro; IPR016156; FAD/NAD-linked_Rdtase_dimer.
DR   InterPro; IPR013027; FAD_pyr_nucl-diS_OxRdtase.
DR   InterPro; IPR006258; Lipoamide_DH.
DR   InterPro; IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
DR   InterPro; IPR023753; Pyr_nucl-diS_OxRdtase_FAD/NAD.
DR   InterPro; IPR012999; Pyr_OxRdtase_I_AS.
DR   InterPro; IPR001327; Pyr_OxRdtase_NAD-bd_dom.
DR   Pfam; PF00070; Pyr_redox; 1.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   Pfam; PF02852; Pyr_redox_dim; 1.
DR   PRINTS; PR00368; FADPNR.
DR   SUPFAM; SSF55424; SSF55424; 1.
DR   TIGRFAMs; TIGR01350; lipoamide_DH; 1.
DR   PROSITE; PS00076; PYRIDINE_REDOX_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome; FAD; Flavoprotein; NAD; Oxidoreductase;
KW   Redox-active center.
SQ   SEQUENCE   477 AA;  50588 MW;  53D5389EE290B291 CRC64;
     MFRRCAVKLN PYDVVVIGGG PGGYVASIKA AQLGMKTACV EKRGTLGGTC LNVGCIPSKA
     LLHATHLYHD AHANFARYGL MGGEGVTMDS AKMQQQKERA VKGLTGGVEY LFKKNKVTYY
     KGEGSFETAH SIRVNGLDGK QEMFETKKTI IATGSEPTEL PFLPFDEKVV LSSTGALALP
     RVPKTMVVIG GGVIGLELGS VWARLGAEVT VVEFAPRCAP TLDEDVTNAL VGALAKNEKM
     KFMTSTKVVG GTNNGDSVSL EVEGKNGKRE TLTCEALLVS VGRRPFTGGL GLDKINVAKN
     ERGFVKIGDH FETSIPDVYA IGDVVDKGPM LAHKAEDEGV ACAEILAGKP GHVNYGVIPA
     VIYTMPEVAS VGKSEEELKK EGVAYKVGKF PFNANSRAKA VSTEDGFVKV LVDKATDRIL
     GVHIVCTTAG ELIGEACLAM EYGASSEDVG RTCHAHPTMS EALKEACMAC FAKTINF
//
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