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Database: UniProt/TrEMBL
Entry: Q4PGV0_USTMA
LinkDB: Q4PGV0_USTMA
Original site: Q4PGV0_USTMA 
ID   Q4PGV0_USTMA            Unreviewed;       849 AA.
AC   Q4PGV0;
DT   19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   19-JUL-2005, sequence version 1.
DT   01-APR-2015, entry version 79.
DE   RecName: Full=E3 ubiquitin-protein ligase {ECO:0000256|PIRNR:PIRNR001569};
DE            EC=6.3.2.- {ECO:0000256|PIRNR:PIRNR001569};
GN   ORFNames=UM00663.1 {ECO:0000313|EMBL:EAK80831.1};
OS   Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX   NCBI_TaxID=237631 {ECO:0000313|EMBL:EAK80831.1, ECO:0000313|Proteomes:UP000000561};
RN   [1] {ECO:0000313|EMBL:EAK80831.1, ECO:0000313|Proteomes:UP000000561}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=521 / FGSC 9021 {ECO:0000313|Proteomes:UP000000561};
RX   PubMed=17080091; DOI=10.1038/nature05248;
RA   Kamper J., Kahmann R., Bolker M., Ma L.J., Brefort T., Saville B.J.,
RA   Banuett F., Kronstad J.W., Gold S.E., Muller O., Perlin M.H.,
RA   Wosten H.A., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA   Snetselaar K., McCann M., Perez-Martin J., Feldbrugge M., Basse C.W.,
RA   Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.,
RA   Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C.,
RA   Molina L., Schirawski J., Mendoza-Mendoza A., Greilinger D., Munch K.,
RA   Rossel N., Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U.,
RA   Sandrock B., Meng S., Ho E.C., Cahill M.J., Boyce K.J., Klose J.,
RA   Klosterman S.J., Deelstra H.J., Ortiz-Castellanos L., Li W.,
RA   Sanchez-Alonso P., Schreier P.H., Hauser-Hahn I., Vaupel M.,
RA   Koopmann E., Friedrich G., Voss H., Schluter T., Margolis J.,
RA   Platt D., Swimmer C., Gnirke A., Chen F., Vysotskaia V., Mannhaupt G.,
RA   Guldener U., Munsterkotter M., Haase D., Oesterheld M., Mewes H.W.,
RA   Mauceli E.W., DeCaprio D., Wade C.M., Butler J., Young S., Jaffe D.B.,
RA   Calvo S., Nusbaum C., Galagan J., Birren B.W.;
RT   "Insights from the genome of the biotrophic fungal plant pathogen
RT   Ustilago maydis.";
RL   Nature 444:97-101(2006).
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|PIRNR:PIRNR001569}.
CC   -!- SIMILARITY: Contains 1 C2 domain. {ECO:0000256|RuleBase:RU003412}.
CC   -!- SIMILARITY: Contains HECT (E6AP-type E3 ubiquitin-protein ligase)
CC       domain. {ECO:0000256|SAAS:SAAS00133827}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EAK80831.1}.
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DR   EMBL; AACP01000016; EAK80831.1; -; Genomic_DNA.
DR   RefSeq; XP_756810.1; XM_751717.1.
DR   ProteinModelPortal; Q4PGV0; -.
DR   SMR; Q4PGV0; 266-297, 371-401, 427-463, 470-841.
DR   STRING; 5270.UM00663.1; -.
DR   EnsemblFungi; UM00663T0; UM00663P0; UM00663.
DR   GeneID; 3628705; -.
DR   KEGG; uma:UM00663.1; -.
DR   eggNOG; COG5021; -.
DR   InParanoid; Q4PGV0; -.
DR   KO; K10591; -.
DR   OMA; HDTIQGK; -.
DR   OrthoDB; EOG735453; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000000561; Unassembled WGS sequence.
DR   GO; GO:0005934; C:cellular bud tip; IEA:EnsemblFungi.
DR   GO; GO:0010008; C:endosome membrane; IEA:EnsemblFungi.
DR   GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IEA:EnsemblFungi.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:EnsemblFungi.
DR   GO; GO:0000151; C:ubiquitin ligase complex; IEA:EnsemblFungi.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:EnsemblFungi.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   GO; GO:0034644; P:cellular response to UV; IEA:EnsemblFungi.
DR   GO; GO:0006333; P:chromatin assembly or disassembly; IEA:EnsemblFungi.
DR   GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IEA:EnsemblFungi.
DR   GO; GO:0007005; P:mitochondrion organization; IEA:EnsemblFungi.
DR   GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; IEA:EnsemblFungi.
DR   GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:EnsemblFungi.
DR   GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IEA:EnsemblFungi.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:EnsemblFungi.
DR   GO; GO:0051865; P:protein autoubiquitination; IEA:EnsemblFungi.
DR   GO; GO:0006513; P:protein monoubiquitination; IEA:EnsemblFungi.
DR   GO; GO:0000209; P:protein polyubiquitination; IEA:EnsemblFungi.
DR   GO; GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:EnsemblFungi.
DR   GO; GO:0032956; P:regulation of actin cytoskeleton organization; IEA:EnsemblFungi.
DR   GO; GO:0010794; P:regulation of dolichol biosynthetic process; IEA:EnsemblFungi.
DR   GO; GO:0032443; P:regulation of ergosterol biosynthetic process; IEA:EnsemblFungi.
DR   GO; GO:0031384; P:regulation of initiation of mating projection growth; IEA:EnsemblFungi.
DR   GO; GO:0010793; P:regulation of mRNA export from nucleus; IEA:EnsemblFungi.
DR   GO; GO:0010796; P:regulation of multivesicular body size; IEA:EnsemblFungi.
DR   GO; GO:0006808; P:regulation of nitrogen utilization; IEA:EnsemblFungi.
DR   GO; GO:0019220; P:regulation of phosphate metabolic process; IEA:EnsemblFungi.
DR   GO; GO:0032880; P:regulation of protein localization; IEA:EnsemblFungi.
DR   GO; GO:2000203; P:regulation of ribosomal large subunit export from nucleus; IEA:EnsemblFungi.
DR   GO; GO:2000232; P:regulation of rRNA processing; IEA:EnsemblFungi.
DR   GO; GO:2000238; P:regulation of tRNA export from nucleus; IEA:EnsemblFungi.
DR   GO; GO:2000235; P:regulation of tRNA processing; IEA:EnsemblFungi.
DR   GO; GO:0010795; P:regulation of ubiquinone biosynthetic process; IEA:EnsemblFungi.
DR   GO; GO:0042493; P:response to drug; IEA:EnsemblFungi.
DR   GO; GO:0034517; P:ribophagy; IEA:EnsemblFungi.
DR   GO; GO:0070086; P:ubiquitin-dependent endocytosis; IEA:EnsemblFungi.
DR   GO; GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IEA:EnsemblFungi.
DR   Gene3D; 2.60.40.150; -; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR024928; E3_ub_ligase_SMURF1.
DR   InterPro; IPR000569; HECT.
DR   InterPro; IPR001202; WW_dom.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF00632; HECT; 1.
DR   Pfam; PF00397; WW; 3.
DR   PIRSF; PIRSF001569; E3_ub_ligase_SMURF1; 1.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00119; HECTc; 1.
DR   SMART; SM00456; WW; 3.
DR   SUPFAM; SSF49562; SSF49562; 1.
DR   SUPFAM; SSF51045; SSF51045; 3.
DR   SUPFAM; SSF56204; SSF56204; 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS50237; HECT; 1.
DR   PROSITE; PS01159; WW_DOMAIN_1; 3.
DR   PROSITE; PS50020; WW_DOMAIN_2; 3.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000561};
KW   Ligase {ECO:0000256|PIRNR:PIRNR001569, ECO:0000256|SAAS:SAAS00133783};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000561};
KW   Ubl conjugation pathway {ECO:0000256|PIRNR:PIRNR001569,
KW   ECO:0000256|SAAS:SAAS00133781}.
FT   ACT_SITE    817    817       Glycyl thioester intermediate.
FT                                {ECO:0000256|PIRSR:PIRSR001569-1}.
SQ   SEQUENCE   849 AA;  94114 MW;  4A4FCFB3127E461A CRC64;
     MVNPRAPGSL SRKIRITVVA ADGLAKRDVF RLPDPFAIVT VDGEQTHSTS VIKKTLNPYW
     NDSFDVNVTD SSVIAVQIFD QKKFKKRDQG FLGVINIRVA DVLDLELGGK RLLNKELKKS
     NDNLVVHGKL IIDLNTNVST PINNNSTAGP TNLLVPGTSN ASSASLATPS SSSVTRSDAP
     PNTSGSGAIA AAATAASTAS TNGDTSSRPA STIDTASSSA SVTVPSSAAT TPSAGVNNEA
     RSSAAPTSTA SRPNPSQDTR SDEYGPLPAG WERRTDHLGR TYYVDHNTRS TTWTRPSTNP
     SANDAAAASS SAADRQRHSN RALADDFLGV NDGDTSRSSA TGSTATSPGA AAASANPLPA
     SSSTTAGNGP LPAGWEQRHT PEGRPYFVDH NTRTTTWVDP RRQQILRIMG PNGSNLTVQP
     QSVSQLGPLP SGWEMRLTST ARVYFVDHNT KTTTWDDPRL PSSLDQNVPQ YKRDFRRKLI
     YFRSQPALRP IPGQCHIKVR RTHIFEDSYA EIMRQQPNDL KKRLMIKFDG EDGLDYGGLS
     REFFFLLSHE MFNPFYCLFE YSAHDNYTLQ INPHSGINPE HLNYFKFIGR VLGLAIFHRR
     FLDAYFIVSF YKMILKKKIT LSDLESVDAD YHRSLQWMLD NSIEGIVEET FTAVEDKFGE
     MVTVELKKGG EEVEVTDENK KEYVDLMTEW RISKRVEEQF KAFISGFTEL IPQDLINVFD
     ERELELLIGG MSEIDVDDWK KFTDYRGFTE QDQVVQWFWQ CVRAWPTEKK SRLLQFATGT
     SRIPVNGFKD LQGSDGPRRF TIEKSGDVNQ LPKSHTCFNR IDLPPYPSFE TLESKLALAI
     EEGMGFGNE
//
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