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Database: UniProt/TrEMBL
Entry: Q4QJU3_HAEI8
LinkDB: Q4QJU3_HAEI8
Original site: Q4QJU3_HAEI8 
ID   Q4QJU3_HAEI8            Unreviewed;       564 AA.
AC   Q4QJU3;
DT   19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   19-JUL-2005, sequence version 1.
DT   19-FEB-2014, entry version 59.
DE   RecName: Full=D-lactate dehydrogenase;
DE            EC=1.1.1.28;
GN   Name=dld; OrderedLocusNames=NTHI1952;
OS   Haemophilus influenzae (strain 86-028NP).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=281310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=86-028NP;
RX   PubMed=15968074; DOI=10.1128/JB.187.13.4627-4636.2005;
RA   Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B.,
RA   Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O.,
RA   Munson R.S. Jr.;
RT   "Genomic sequence of an otitis media isolate of nontypeable
RT   Haemophilus influenzae: comparative study with H. influenzae serotype
RT   d, strain KW20.";
RL   J. Bacteriol. 187:4627-4636(2005).
CC   -!- FUNCTION: First component of the membrane-bound D-lactate oxidase,
CC       which is believed to play an important role in the energization of
CC       the active transport of a variety of sugars and amino acids (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: (R)-lactate + NAD(+) = pyruvate + NADH.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- SIMILARITY: Contains FAD-binding PCMH-type domain.
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DR   EMBL; CP000057; AAX88704.1; -; Genomic_DNA.
DR   RefSeq; YP_249364.1; NC_007146.2.
DR   ProteinModelPortal; Q4QJU3; -.
DR   SMR; Q4QJU3; 4-562.
DR   STRING; 281310.NTHI1952; -.
DR   EnsemblBacteria; AAX88704; AAX88704; NTHI1952.
DR   GeneID; 3431204; -.
DR   KEGG; hit:NTHI1952; -.
DR   PATRIC; 20183924; VBIHaeInf100748_1797.
DR   eggNOG; COG0277; -.
DR   HOGENOM; HOG000122232; -.
DR   KO; K03777; -.
DR   OMA; GRKAFLH; -.
DR   OrthoDB; EOG6Z3KJX; -.
DR   ProtClustDB; PRK11183; -.
DR   BioCyc; HINF281310:GJ89-1800-MONOMER; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0008720; F:D-lactate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0008762; F:UDP-N-acetylmuramate dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006089; P:lactate metabolic process; IEA:InterPro.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 3.30.1370.20; -; 1.
DR   Gene3D; 3.30.43.10; -; 1.
DR   Gene3D; 3.30.465.10; -; 1.
DR   Gene3D; 3.30.70.610; -; 2.
DR   InterPro; IPR016169; CO_DH_flavot_FAD-bd_sub2.
DR   InterPro; IPR016172; D-lactate_DH_C-sub1.
DR   InterPro; IPR016173; D-lactate_DH_C-sub2.
DR   InterPro; IPR012256; D_lactate_DH.
DR   InterPro; IPR016166; FAD-bd_2.
DR   InterPro; IPR016167; FAD-bd_2_sub1.
DR   InterPro; IPR016164; FAD-linked_Oxase-like_C.
DR   InterPro; IPR015409; Lactate_DH_C.
DR   InterPro; IPR006094; Oxid_FAD_bind_N.
DR   Pfam; PF01565; FAD_binding_4; 1.
DR   Pfam; PF09330; Lact-deh-memb; 1.
DR   PIRSF; PIRSF000101; D-lactate_dh; 1.
DR   SUPFAM; SSF55103; SSF55103; 1.
DR   SUPFAM; SSF56176; SSF56176; 1.
DR   PROSITE; PS51387; FAD_PCMH; 1.
PE   3: Inferred from homology;
KW   Complete proteome; FAD; Flavoprotein; NAD; Oxidoreductase.
SQ   SEQUENCE   564 AA;  64092 MW;  A4879692317974BA CRC64;
     MSVQQLISRL TDIVGSRYII TDPTKTEAYR SGYRFGTGNA LAVVRPATLL EFWNIVKVCV
     EHDVIVINQA ANTGLTGGST PDGNDYDRDI VVINTMRIDG IKLINNASQV ICLPGSTLNE
     LENQLKPFGR EPHSVIGSSC IGASVIGGIC NNSGGALVQR GPAYTEMALY AQLNEKGELE
     LKNHLGIDLG ETPEEILTNL QEKRYQVKDI RQDCGHGHDH YYCNYVRQVD EGSPARFNAD
     PARHYEASGC AGKLAVFAVR LDTFPLEKET AVFYIGTNQT SVLSDIRRHM LVNFEVLPIS
     GEYIHRDAFD IAAKYGKDTF WVIKKFGTHW LPKLFSLKSN VDRIGKKFFF LPQHLSDKLM
     QTVSKFIPEH LPQSLWDYRN KYEHHLIIKM GGKGIQEARE YLESYIADGS KGGYFECNAI
     ETQAAMLHRF AVASAAIRYR AIHEKEVEEI VALDVALRRN DQDWFEVLPP EIDNRIISKL
     YYGHFMCHVF HQDYIVKKGY DYEELEYEML KLLDKRGAQY PAEHNVGHLY EAKPTLRKFY
     KELDPTNSFN PGIGKTTRKK YWAE
//
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