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Database: UniProt/TrEMBL
Entry: Q4WSZ6_ASPFU
LinkDB: Q4WSZ6_ASPFU
Original site: Q4WSZ6_ASPFU 
ID   Q4WSZ6_ASPFU            Unreviewed;       455 AA.
AC   Q4WSZ6;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 2.
DT   05-JUL-2017, entry version 79.
DE   SubName: Full=Histone-lysine N-methyltransferase Clr4 {ECO:0000313|EMBL:EAL90436.2};
DE            EC=2.1.1.43 {ECO:0000313|EMBL:EAL90436.2};
GN   ORFNames=AFUA_1G11090 {ECO:0000313|EMBL:EAL90436.2};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL90436.2, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL90436.2, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S.,
RA   Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.,
RA   Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S.,
RA   Farman M., Fedorova N., Fedorova N., Feldblyum T.V., Fischer R.,
RA   Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A.,
RA   Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.,
RA   Haas H., Harris D., Horiuchi H., Huang J., Humphray S., Jimenez J.,
RA   Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S.,
RA   Kulkarni R., Kumagai T., Lafon A., Latge J.P., Li W., Lord A., Lu C.,
RA   Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M.,
RA   Mouyna I., Mulligan S., Murphy L., O'Neil S., Paulsen I.,
RA   Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M.,
RA   Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S.,
RA   Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J.,
RA   White O., Woodward J., Yu J.H., Fraser C., Galagan J.E., Asai K.,
RA   Machida M., Hall N., Barrell B., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC       {ECO:0000256|SAAS:SAAS00591578}.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|SAAS:SAAS00563877}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00574581}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EAL90436.2}.
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DR   EMBL; AAHF01000004; EAL90436.2; -; Genomic_DNA.
DR   RefSeq; XP_752474.2; XM_747381.2.
DR   ProteinModelPortal; Q4WSZ6; -.
DR   STRING; 5085.CADAFUBP00001032; -.
DR   EnsemblFungi; CADAFUAT00007480; CADAFUAP00007480; CADAFUAG00007480.
DR   GeneID; 3510402; -.
DR   KEGG; afm:AFUA_1G11090; -.
DR   EuPathDB; FungiDB:Afu1g11090; -.
DR   HOGENOM; HOG000207341; -.
DR   InParanoid; Q4WSZ6; -.
DR   KO; K11419; -.
DR   OMA; FIDCYLG; -.
DR   OrthoDB; EOG092C2EWO; -.
DR   Proteomes; UP000002530; Chromosome 1.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR007728; Pre-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF05033; Pre-SET; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50867; PRE_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   Chromosome {ECO:0000256|SAAS:SAAS00508265};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002530};
KW   Methyltransferase {ECO:0000256|SAAS:SAAS00590675,
KW   ECO:0000313|EMBL:EAL90436.2};
KW   Nucleus {ECO:0000256|SAAS:SAAS00574642};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW   S-adenosyl-L-methionine {ECO:0000256|SAAS:SAAS00591079};
KW   Transferase {ECO:0000256|SAAS:SAAS00591533,
KW   ECO:0000313|EMBL:EAL90436.2}.
FT   DOMAIN      215    289       Pre-SET. {ECO:0000259|PROSITE:PS50867}.
FT   DOMAIN      292    418       SET. {ECO:0000259|PROSITE:PS50280}.
FT   DOMAIN      430    446       Post-SET. {ECO:0000259|PROSITE:PS50868}.
SQ   SEQUENCE   455 AA;  51187 MW;  CC360D5E08A784C0 CRC64;
     MLTGAFFPDI TRLIGPASRD CLIEGLGNHS NPITSNSNTA NNAIAKANTP DPNHVFNPKI
     QNPSTPSPTP SSQQEAVGVV IPSPSRQLRK EIEKSVWVKA PPVTPEKTAL STEYYPIDAH
     EKRALRGAYP SARKVKRSEI PFSIGTPGPI LADRIPVQRQ LHETLQRKLS KINGPPVTFA
     PGEEDLLAVF ASNFEFVNSY ILRKGVSHIP ADFIAGCDCK KICDPARCGC LEQDEESKEI
     IVPYQRAQDD ARLLVLTPDF LKRTDIIIEC SSKCTCDERK CWNRVVQHGR TVRLEIFHTG
     NRGFGLRSPD WIRAGQFIDC YLGEVITKQE ADVREEVVTS QHGHSYLFEL DFFHNDDEIY
     VVDGQKFGSP TRFMNHSCNP NCKLFPVTRT YGDERLYDLA FFSLHNIPPN TELTFDYNPN
     WEEGKKVDPN AVRCLCGEKN CRGQLWPNQR KGTKC
//
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