GenomeNet

Database: UniProt/TrEMBL
Entry: Q55XR2_CRYNB
LinkDB: Q55XR2_CRYNB
Original site: Q55XR2_CRYNB 
ID   Q55XR2_CRYNB            Unreviewed;       488 AA.
AC   Q55XR2;
DT   24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT   24-MAY-2005, sequence version 1.
DT   07-JUN-2017, entry version 71.
DE   RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007};
DE            EC=2.7.1.- {ECO:0000256|RuleBase:RU362007};
GN   OrderedLocusNames=CNBB3020 {ECO:0000313|EMBL:EAL22423.1};
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Tremellomycetes; Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643 {ECO:0000313|EMBL:EAL22423.1, ECO:0000313|Proteomes:UP000001435};
RN   [1] {ECO:0000313|Proteomes:UP000001435}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A {ECO:0000313|Proteomes:UP000001435};
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J.,
RA   D'Souza C.A., Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J.,
RA   Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I.,
RA   Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E.,
RA   Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L.,
RA   Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A.,
RA   Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R.,
RA   Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W.,
RA   Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen
RT   Cryptococcus neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|RuleBase:RU362007, ECO:0000256|SAAS:SAAS00672880}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EAL22423.1}.
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DR   EMBL; AAEY01000010; EAL22423.1; -; Genomic_DNA.
DR   RefSeq; XP_777070.1; XM_771977.1.
DR   ProteinModelPortal; Q55XR2; -.
DR   STRING; 283643.XP_777070.1; -.
DR   EnsemblFungi; EAL22423; EAL22423; CNBB3020.
DR   GeneID; 4934395; -.
DR   KEGG; cnb:CNBB3020; -.
DR   EuPathDB; FungiDB:CNBB3020; -.
DR   eggNOG; KOG1369; Eukaryota.
DR   eggNOG; COG5026; LUCA.
DR   KO; K00844; -.
DR   OrthoDB; EOG092C2JW4; -.
DR   Proteomes; UP000001435; Chromosome 2.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001678; P:cellular glucose homeostasis; IEA:InterPro.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-KW.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR019807; Hexokinase_BS.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; PTHR19443; 1.
DR   Pfam; PF00349; Hexokinase_1; 1.
DR   Pfam; PF03727; Hexokinase_2; 1.
DR   PROSITE; PS00378; HEXOKINASE_1; 1.
DR   PROSITE; PS51748; HEXOKINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672869};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001435};
KW   Glycolysis {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672870};
KW   Kinase {ECO:0000256|RuleBase:RU362007, ECO:0000256|SAAS:SAAS00672871};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672883};
KW   Transferase {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672884}.
FT   DOMAIN        8    206       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      213    465       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
SQ   SEQUENCE   488 AA;  53511 MW;  E032CE4290FC970D CRC64;
     MTLPEVCKQF EPYFILDDAK LVDIVKHFRK EMEEGLASYG KDMAMIPTFV TGVPDGTEEG
     VFLALDLGGT NLRVCLILLQ GHNQFKIKQQ KYKVSEELKT GQARVLFDYI AESVDNFLTE
     VESHEDIAIP ATGEPMHLGF TFSFPVEQTA IDAGKLLTWT KGFNTKNAIG HDVVRLLQDA
     FDRKHMHVRC SALVNDTVGT LLSRSYQSGP ALIGAIFGTG TNGAYIDKTR TISKLGKEKI
     EDAEEGGEHA GEFMVVNMEW GAFDNKRQCL PISLFDNKLD RESINPRKQA FEKLVSGMYL
     GEITRNMLLY MIDSSLLFGG HSSEIINTHY GFDTSFVSGI EGISSPEEVK KLIVKELKVD
     PKHVTDKCPE IVQWAVRLVS DRACKLAACA IAAVVLHTGN DKAPEGEEDK GVDVGVDGSV
     AEFLPMFSER VMAALKAILG EKSAARVKLG LAKDGSGVGA ALTALQAKKA LDRRSDRSMK
     FVPGERGP
//
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