ID   Q59E68_DROME            Unreviewed;       597 AA.
AC   Q59E68;
DT   26-APR-2005, integrated into UniProtKB/TrEMBL.
DT   26-APR-2005, sequence version 1.
DT   01-MAY-2013, entry version 68.
DE   SubName: Full=Lethal (1) G0232, isoform F;
DE            EC=3.1.3.48;
GN   Name=l(1)G0232; ORFNames=Dmel_CG32697;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA   Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA   Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
RA   Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC   -!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein
CC       tyrosine + phosphate.
CC   -!- SIMILARITY: Contains 1 CRAL-TRIO domain.
CC   -!- SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AE014298; AAX52482.1; -; Genomic_DNA.
DR   RefSeq; NP_001014728.1; NM_001014728.3.
DR   UniGene; Dm.20620; -.
DR   ProteinModelPortal; Q59E68; -.
DR   SMR; Q59E68; 288-581.
DR   PaxDb; Q59E68; -.
DR   PRIDE; Q59E68; -.
DR   EnsemblMetazoa; FBtr0100193; FBpp0099559; FBgn0028341.
DR   GeneID; 31907; -.
DR   KEGG; dme:Dmel_CG32697; -.
DR   UCSC; CG32697-RF; d. melanogaster.
DR   FlyBase; FBgn0028341; l(1)G0232.
DR   eggNOG; COG5599; -.
DR   GeneTree; ENSGT00700000104092; -.
DR   KO; K01104; -.
DR   OrthoDB; EOG444J1Z; -.
DR   ChiTaRS; l(1)G0232; drosophila.
DR   GenomeRNAi; 31907; -.
DR   NextBio; 775872; -.
DR   Bgee; Q59E68; -.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; NAS:FlyBase.
DR   GO; GO:0022008; P:neurogenesis; IMP:FlyBase.
DR   GO; GO:0006911; P:phagocytosis, engulfment; IMP:FlyBase.
DR   Gene3D; 3.40.525.10; -; 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR000387; Tyr/Dual-sp_Pase.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR000242; Tyr_Pase_rcpt/non-rcpt.
DR   Pfam; PF00650; CRAL_TRIO; 1.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00194; PTPc; 1.
DR   SUPFAM; SSF52087; CRAL_TRIO_C; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE   4: Predicted;
KW   Complete proteome; Hydrolase; Protein phosphatase; Reference proteome.
SQ   SEQUENCE   597 AA;  64629 MW;  CF403A1C815B1FDA CRC64;
     MSGSKYSNFD YDLSQKILTL LKGGYPARLK KVLIVTAPLW FKAPFKILRL FVREKLRERV
     FTVSVPQLAL HVPRKALPIH LGGTLEVDHA TWLLSCRQSM TNREDELLAN IVGVGGGSGS
     GSAAGSAAIV STNGTETEAA TTAATIISAV HQLGDNNTTV VTVSNGVGPA GSASGGATTA
     ASAATEPNEN ITINGLSPSH RQAANNSSSS SSSAATVANP LKLNTSGSAD NNSTITNATT
     AAGAAGAAAG TTTNGGGEFW SENPPSSASS GFSDDDSLAG QEGDPKPIDQ IVQMVKQRGR
     HGLIKEYADI RNRAPEGTFL HARMRANLTK NRYTDVLCYD HSRVVLAHED GDEPSDYINA
     NFVDGYKQKN AYISTQGPLP KTSQDFWRMI WEQHCLVIVM TTRVMERGRV KCGQYWEPTE
     ESSLEFGDYH VRTISVECNE DYMVASLELR NIKTDEIRNV SHWQFTSWPD YGVPSSAMAM
     LNFLQKVREK QAQLVQGLGD TWAGHPRGPP IVVHCSAGIG RTGTFITLDI CISRLEDVGT
     ADIRGTVEKI RSQRAYSIQM PDQYVFCHLA LIEYAYSRGM LQTVDLAGFD EREPDSE
//

ID   Q8IRM6_DROME            Unreviewed;       498 AA.
AC   Q8IRM6;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   01-MAY-2013, entry version 82.
DE   SubName: Full=Lethal (1) G0232, isoform D;
DE            EC=3.1.3.48;
DE   SubName: Full=Lethal (1) G0232, isoform E;
DE            EC=3.1.3.48;
GN   Name=l(1)G0232; ORFNames=Dmel_CG32697;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA   Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA   Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
RA   Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC   -!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein
CC       tyrosine + phosphate.
CC   -!- SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AE014298; AAN09611.1; -; Genomic_DNA.
DR   EMBL; AE014298; AAX52483.1; -; Genomic_DNA.
DR   RefSeq; NP_001014729.1; NM_001014729.3.
DR   RefSeq; NP_001188574.1; NM_001201645.2.
DR   RefSeq; NP_001259386.1; NM_001272457.1.
DR   RefSeq; NP_727358.1; NM_167199.3.
DR   UniGene; Dm.20620; -.
DR   HSSP; P10586; 1LAR.
DR   SMR; Q8IRM6; 189-482.
DR   EnsemblMetazoa; FBtr0071407; FBpp0099557; FBgn0028341.
DR   EnsemblMetazoa; FBtr0100192; FBpp0099558; FBgn0028341.
DR   EnsemblMetazoa; FBtr0303559; FBpp0292592; FBgn0028341.
DR   EnsemblMetazoa; FBtr0333427; FBpp0305618; FBgn0028341.
DR   GeneID; 31907; -.
DR   KEGG; dme:Dmel_CG32697; -.
DR   UCSC; CG32697-RD; d. melanogaster.
DR   FlyBase; FBgn0028341; l(1)G0232.
DR   GeneTree; ENSGT00700000104092; -.
DR   InParanoid; Q8IRM6; -.
DR   KO; K01104; -.
DR   ChiTaRS; l(1)G0232; drosophila.
DR   GenomeRNAi; 31907; -.
DR   NextBio; 775872; -.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; NAS:FlyBase.
DR   GO; GO:0022008; P:neurogenesis; IMP:FlyBase.
DR   GO; GO:0006911; P:phagocytosis, engulfment; IMP:FlyBase.
DR   InterPro; IPR000387; Tyr/Dual-sp_Pase.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR000242; Tyr_Pase_rcpt/non-rcpt.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00194; PTPc; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE   4: Predicted;
KW   Complete proteome; Hydrolase; Protein phosphatase; Reference proteome.
SQ   SEQUENCE   498 AA;  53329 MW;  8E5694DD08E6F887 CRC64;
     MTNREDELLA NIVGVGGGSG SGSAAGSAAI VSTNGTETEA ATTAATIISA VHQLGDNNTT
     VVTVSNGVGP AGSASGGATT AASAATEPNE NITINGLSPS HRQAANNSSS SSSSAATVAN
     PLKLNTSGSA DNNSTITNAT TAAGAAGAAA GTTTNGGGEF WSENPPSSAS SGFSDDDSLA
     GQEGDPKPID QIVQMVKQRG RHGLIKEYAD IRNRAPEGTF LHARMRANLT KNRYTDVLCY
     DHSRVVLAHE DGDEPSDYIN ANFVDGYKQK NAYISTQGPL PKTSQDFWRM IWEQHCLVIV
     MTTRVMERGR VKCGQYWEPT EESSLEFGDY HVRTISVECN EDYMVASLEL RNIKTDEIRN
     VSHWQFTSWP DYGVPSSAMA MLNFLQKVRE KQAQLVQGLG DTWAGHPRGP PIVVHCSAGI
     GRTGTFITLD ICISRLEDVG TADIRGTVEK IRSQRAYSIQ MPDQYVFCHL ALIEYAYSRG
     MLQTVDLAGF DEREPDSE
//

ID   Q8IRM7_DROME            Unreviewed;       797 AA.
AC   Q8IRM7;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   01-MAY-2013, entry version 92.
DE   SubName: Full=LD30065p;
DE   SubName: Full=Lethal (1) G0232, isoform C;
DE            EC=3.1.3.48;
GN   Name=l(1)G0232; Synonyms=l(1)G0232-RC; ORFNames=Dmel_CG32697;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA   Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA   Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
RA   Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Berkeley;
RA   Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein
CC       tyrosine + phosphate.
CC   -!- SIMILARITY: Contains 1 CRAL-TRIO domain.
CC   -!- SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AE014298; AAN09610.1; -; Genomic_DNA.
DR   EMBL; BT120027; ADA53566.1; -; mRNA.
DR   RefSeq; NP_727356.1; NM_167197.3.
DR   UniGene; Dm.20620; -.
DR   HSSP; P10586; 1LAR.
DR   SMR; Q8IRM7; 94-285, 488-781.
DR   EnsemblMetazoa; FBtr0071404; FBpp0099556; FBgn0028341.
DR   GeneID; 31907; -.
DR   KEGG; dme:Dmel_CG32697; -.
DR   UCSC; CG32697-RC; d. melanogaster.
DR   FlyBase; FBgn0028341; l(1)G0232.
DR   GeneTree; ENSGT00700000104092; -.
DR   InParanoid; Q8IRM7; -.
DR   KO; K01104; -.
DR   ChiTaRS; l(1)G0232; drosophila.
DR   GenomeRNAi; 31907; -.
DR   NextBio; 775872; -.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; NAS:FlyBase.
DR   GO; GO:0022008; P:neurogenesis; IMP:FlyBase.
DR   GO; GO:0006911; P:phagocytosis, engulfment; IMP:FlyBase.
DR   Gene3D; 3.40.525.10; -; 2.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR011074; CRAL/TRIO_N_dom.
DR   InterPro; IPR000387; Tyr/Dual-sp_Pase.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR000242; Tyr_Pase_rcpt/non-rcpt.
DR   Pfam; PF00650; CRAL_TRIO; 1.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM01100; CRAL_TRIO_N; 1.
DR   SMART; SM00194; PTPc; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF52087; CRAL_TRIO_C; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Hydrolase; Protein phosphatase; Reference proteome.
SQ   SEQUENCE   797 AA;  85757 MW;  1099AFA9A1E648C9 CRC64;
     MEAEQQEFAV KQFIDLCNNL GANCSTTTAT SPSTSSSSAS STQNLIAVVP PQLQQLQVQL
     PAPGGGGGAG AGGGGGGGGG AAPVRRHISH TTAVKFLYAR KFDIPRAVSL YEQHEQIRLK
     EYLYNIDPDV EPLRSELQTG KFTILPARTS SGAAIALFTA NRHSPLSVSH TTTLQGIVYQ
     LDSALQDSET QRAGLVFIYD MSGSKYSNFD YDLSQKILTL LKGGYPARLK KVLIVTAPLW
     FKAPFKILRL FVREKLRERV FTVSVPQLAL HVPRKALPIH LGGTLEVDHA TWLLSCRQSM
     TNREDELLAN IVGVGGGSGS GSAAGSAAIV STNGTETEAA TTAATIISAV HQLGDNNTTV
     VTVSNGVGPA GSASGGATTA ASAATEPNEN ITINGLSPSH RQAANNSSSS SSSAATVANP
     LKLNTSGSAD NNSTITNATT AAGAAGAAAG TTTNGGGEFW SENPPSSASS GFSDDDSLAG
     QEGDPKPIDQ IVQMVKQRGR HGLIKEYADI RNRAPEGTFL HARMRANLTK NRYTDVLCYD
     HSRVVLAHED GDEPSDYINA NFVDGYKQKN AYISTQGPLP KTSQDFWRMI WEQHCLVIVM
     TTRVMERGRV KCGQYWEPTE ESSLEFGDYH VRTISVECNE DYMVASLELR NIKTDEIRNV
     SHWQFTSWPD YGVPSSAMAM LNFLQKVREK QAQLVQGLGD TWAGHPRGPP IVVHCSAGIG
     RTGTFITLDI CISRLEDVGT ADIRGTVEKI RSQRAYSIQM PDQYVFCHLA LIEYAYSRGM
     LQTVDLAGFD EREPDSE
//

ID   Q9W323_DROME            Unreviewed;       827 AA.
AC   Q9W323; Q960Z9;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2002, sequence version 2.
DT   01-MAY-2013, entry version 102.
DE   SubName: Full=LD27988p;
DE   SubName: Full=Lethal (1) G0232, isoform A;
DE            EC=3.1.3.48;
GN   Name=l(1)G0232; Synonyms=CG3101; ORFNames=CG32697, Dmel_CG32697;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA   Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA   Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
RA   Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Berkeley;
RA   Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.,
RA   Champe M., Chavez C., Dorsett V., Farfan D., Frise E., George R.,
RA   Gonzalez M., Guarin H., Li P., Liao G., Miranda A., Mungall C.J.,
RA   Nunoo J., Pacleb J., Paragas V., Park S., Phouanenavong S., Wan K.,
RA   Yu C., Lewis S.E., Rubin G.M., Celniker S.;
RL   Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC   -!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein
CC       tyrosine + phosphate.
CC   -!- SIMILARITY: Contains 1 CRAL-TRIO domain.
CC   -!- SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AE014298; AAF46514.2; -; Genomic_DNA.
DR   EMBL; AY051749; AAK93173.1; -; mRNA.
DR   RefSeq; NP_572576.1; NM_132348.3.
DR   UniGene; Dm.20620; -.
DR   HSSP; P10586; 1LAR.
DR   SMR; Q9W323; 124-315, 518-811.
DR   EnsemblMetazoa; FBtr0071405; FBpp0099554; FBgn0028341.
DR   GeneID; 31907; -.
DR   KEGG; dme:Dmel_CG32697; -.
DR   UCSC; CG32697-RA; d. melanogaster.
DR   FlyBase; FBgn0028341; l(1)G0232.
DR   GeneTree; ENSGT00700000104092; -.
DR   InParanoid; Q9W323; -.
DR   KO; K01104; -.
DR   OMA; WEPTEES; -.
DR   ChiTaRS; l(1)G0232; drosophila.
DR   GenomeRNAi; 31907; -.
DR   NextBio; 775872; -.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; NAS:FlyBase.
DR   GO; GO:0022008; P:neurogenesis; IMP:FlyBase.
DR   GO; GO:0006911; P:phagocytosis, engulfment; IMP:FlyBase.
DR   Gene3D; 3.40.525.10; -; 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR011074; CRAL/TRIO_N_dom.
DR   InterPro; IPR000387; Tyr/Dual-sp_Pase.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR000242; Tyr_Pase_rcpt/non-rcpt.
DR   Pfam; PF00650; CRAL_TRIO; 1.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM01100; CRAL_TRIO_N; 1.
DR   SMART; SM00194; PTPc; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF52087; CRAL_TRIO_C; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Hydrolase; Protein phosphatase; Reference proteome.
SQ   SEQUENCE   827 AA;  89284 MW;  36E39FF0950EB242 CRC64;
     MQQTQWNKDR QEDRNNNSGS RSEQDSGCHR RLFLCIAKAV KQFIDLCNNL GANCSTTTAT
     SPSTSSSSAS STQNLIAVVP PQLQQLQVQL PAPGGGGGAG AGGGGGGGGG AAPVRRHISH
     TTAVKFLYAR KFDIPRAVSL YEQHEQIRLK EYLYNIDPDV EPLRSELQTG KFTILPARTS
     SGAAIALFTA NRHSPLSVSH TTTLQGIVYQ LDSALQDSET QRAGLVFIYD MSGSKYSNFD
     YDLSQKILTL LKGGYPARLK KVLIVTAPLW FKAPFKILRL FVREKLRERV FTVSVPQLAL
     HVPRKALPIH LGGTLEVDHA TWLLSCRQSM TNREDELLAN IVGVGGGSGS GSAAGSAAIV
     STNGTETEAA TTAATIISAV HQLGDNNTTV VTVSNGVGPA GSASGGATTA ASAATEPNEN
     ITINGLSPSH RQAANNSSSS SSSAATVANP LKLNTSGSAD NNSTITNATT AAGAAGAAAG
     TTTNGGGEFW SENPPSSASS GFSDDDSLAG QEGDPKPIDQ IVQMVKQRGR HGLIKEYADI
     RNRAPEGTFL HARMRANLTK NRYTDVLCYD HSRVVLAHED GDEPSDYINA NFVDGYKQKN
     AYISTQGPLP KTSQDFWRMI WEQHCLVIVM TTRVMERGRV KCGQYWEPTE ESSLEFGDYH
     VRTISVECNE DYMVASLELR NIKTDEIRNV SHWQFTSWPD YGVPSSAMAM LNFLQKVREK
     QAQLVQGLGD TWAGHPRGPP IVVHCSAGIG RTGTFITLDI CISRLEDVGT ADIRGTVEKI
     RSQRAYSIQM PDQYVFCHLA LIEYAYSRGM LQTVDLAGFD EREPDSE
//

ID   Q9W324_DROME            Unreviewed;       802 AA.
AC   Q9W324;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 2.
DT   01-MAY-2013, entry version 99.
DE   SubName: Full=LP18470p;
DE   SubName: Full=Lethal (1) G0232, isoform B;
DE            EC=3.1.3.48;
GN   Name=l(1)G0232; Synonyms=l(1)G0232-RB; ORFNames=Dmel_CG32697;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA   Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA   Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
RA   Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Berkeley;
RA   Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL   Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein
CC       tyrosine + phosphate.
CC   -!- SIMILARITY: Contains 1 CRAL-TRIO domain.
CC   -!- SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AE014298; AAF46513.2; -; Genomic_DNA.
DR   EMBL; BT099668; ACV32768.1; -; mRNA.
DR   RefSeq; NP_727357.1; NM_167198.2.
DR   UniGene; Dm.20620; -.
DR   HSSP; P10586; 1LAR.
DR   SMR; Q9W324; 99-290, 493-786.
DR   STRING; 7227.FBpp0099554; -.
DR   EnsemblMetazoa; FBtr0071406; FBpp0099555; FBgn0028341.
DR   GeneID; 31907; -.
DR   KEGG; dme:Dmel_CG32697; -.
DR   UCSC; CG32697-RB; d. melanogaster.
DR   FlyBase; FBgn0028341; l(1)G0232.
DR   GeneTree; ENSGT00700000104092; -.
DR   InParanoid; Q9W324; -.
DR   KO; K01104; -.
DR   ChiTaRS; l(1)G0232; drosophila.
DR   GenomeRNAi; 31907; -.
DR   NextBio; 775872; -.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; NAS:FlyBase.
DR   GO; GO:0022008; P:neurogenesis; IMP:FlyBase.
DR   GO; GO:0006911; P:phagocytosis, engulfment; IMP:FlyBase.
DR   Gene3D; 3.40.525.10; -; 2.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR011074; CRAL/TRIO_N_dom.
DR   InterPro; IPR000387; Tyr/Dual-sp_Pase.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR000242; Tyr_Pase_rcpt/non-rcpt.
DR   Pfam; PF00650; CRAL_TRIO; 1.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM01100; CRAL_TRIO_N; 1.
DR   SMART; SM00194; PTPc; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF52087; CRAL_TRIO_C; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Hydrolase; Protein phosphatase; Reference proteome.
SQ   SEQUENCE   802 AA;  86532 MW;  D509838CAC5B00B4 CRC64;
     MVHLYQRRRN REQAVKQFID LCNNLGANCS TTTATSPSTS SSSASSTQNL IAVVPPQLQQ
     LQVQLPAPGG GGGAGAGGGG GGGGGAAPVR RHISHTTAVK FLYARKFDIP RAVSLYEQHE
     QIRLKEYLYN IDPDVEPLRS ELQTGKFTIL PARTSSGAAI ALFTANRHSP LSVSHTTTLQ
     GIVYQLDSAL QDSETQRAGL VFIYDMSGSK YSNFDYDLSQ KILTLLKGGY PARLKKVLIV
     TAPLWFKAPF KILRLFVREK LRERVFTVSV PQLALHVPRK ALPIHLGGTL EVDHATWLLS
     CRQSMTNRED ELLANIVGVG GGSGSGSAAG SAAIVSTNGT ETEAATTAAT IISAVHQLGD
     NNTTVVTVSN GVGPAGSASG GATTAASAAT EPNENITING LSPSHRQAAN NSSSSSSSAA
     TVANPLKLNT SGSADNNSTI TNATTAAGAA GAAAGTTTNG GGEFWSENPP SSASSGFSDD
     DSLAGQEGDP KPIDQIVQMV KQRGRHGLIK EYADIRNRAP EGTFLHARMR ANLTKNRYTD
     VLCYDHSRVV LAHEDGDEPS DYINANFVDG YKQKNAYIST QGPLPKTSQD FWRMIWEQHC
     LVIVMTTRVM ERGRVKCGQY WEPTEESSLE FGDYHVRTIS VECNEDYMVA SLELRNIKTD
     EIRNVSHWQF TSWPDYGVPS SAMAMLNFLQ KVREKQAQLV QGLGDTWAGH PRGPPIVVHC
     SAGIGRTGTF ITLDICISRL EDVGTADIRG TVEKIRSQRA YSIQMPDQYV FCHLALIEYA
     YSRGMLQTVD LAGFDEREPD SE
//