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Database: UniProt/TrEMBL
Entry: Q5H5H9_XANOR
LinkDB: Q5H5H9_XANOR
Original site: Q5H5H9_XANOR 
ID   Q5H5H9_XANOR            Unreviewed;       429 AA.
AC   Q5H5H9;
DT   01-MAR-2005, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2005, sequence version 1.
DT   26-NOV-2014, entry version 82.
DE   RecName: Full=Phosphoribosylamine--glycine ligase {ECO:0000256|HAMAP-Rule:MF_00138};
DE            EC=6.3.4.13 {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=GARS {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Glycinamide ribonucleotide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Phosphoribosylglycinamide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
GN   Name=purD {ECO:0000256|HAMAP-Rule:MF_00138,
GN   ECO:0000313|EMBL:AAW73791.1};
GN   OrderedLocusNames=XOO0537 {ECO:0000313|EMBL:AAW73791.1};
OS   Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xanthomonas.
OX   NCBI_TaxID=291331 {ECO:0000313|EMBL:AAW73791.1, ECO:0000313|Proteomes:UP000006735};
RN   [1] {ECO:0000313|EMBL:AAW73791.1, ECO:0000313|Proteomes:UP000006735}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KACC10331 / KXO85 {ECO:0000313|Proteomes:UP000006735};
RX   PubMed=15673718; DOI=10.1093/nar/gki206;
RA   Lee B.-M., Park Y.-J., Park D.-S., Kang H.-W., Kim J.-G., Song E.-S.,
RA   Park I.-C., Yoon U.-H., Hahn J.-H., Koo B.-S., Lee G.-B., Kim H.,
RA   Park H.-S., Yoon K.-O., Kim J.-H., Jung C.-H., Koh N.-H., Seo J.-S.,
RA   Go S.-J.;
RT   "The genome sequence of Xanthomonas oryzae pathovar oryzae KACC10331,
RT   the bacterial blight pathogen of rice.";
RL   Nucleic Acids Res. 33:577-586(2005).
CC   -!- CATALYTIC ACTIVITY: ATP + 5-phospho-D-ribosylamine + glycine = ADP
CC       + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide.
CC       {ECO:0000256|HAMAP-Rule:MF_00138}.
CC   -!- COFACTOR:
CC       Note=Binds 1 magnesium or manganese ion per subunit.
CC       {ECO:0000256|HAMAP-Rule:MF_00138};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-
CC       ribose 1-diphosphate: step 2/2. {ECO:0000256|HAMAP-Rule:MF_00138}.
CC   -!- SIMILARITY: Belongs to the GARS family. {ECO:0000256|HAMAP-
CC       Rule:MF_00138}.
CC   -!- SIMILARITY: Contains 1 ATP-grasp domain. {ECO:0000256|HAMAP-
CC       Rule:MF_00138}.
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DR   EMBL; AE013598; AAW73791.1; -; Genomic_DNA.
DR   RefSeq; YP_199176.1; NC_006834.1.
DR   ProteinModelPortal; Q5H5H9; -.
DR   SMR; Q5H5H9; 1-425.
DR   STRING; 291331.XOO0537; -.
DR   EnsemblBacteria; AAW73791; AAW73791; XOO0537.
DR   GeneID; 3262487; -.
DR   KEGG; xoo:XOO0537; -.
DR   PATRIC; 24099901; VBIXanOry111333_0602.
DR   KO; K01945; -.
DR   OMA; DIHWDGS; -.
DR   OrthoDB; EOG69SKD1; -.
DR   BioCyc; XORY291331:GJBV-484-MONOMER; -.
DR   UniPathway; UPA00074; UER00125.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.30.470.20; -; 1.
DR   Gene3D; 3.40.50.20; -; 1.
DR   Gene3D; 3.90.600.10; -; 1.
DR   HAMAP; MF_00138; GARS; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR013816; ATP_grasp_subdomain_2.
DR   InterPro; IPR016185; PreATP-grasp_dom.
DR   InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp.
DR   InterPro; IPR000115; PRibGlycinamide_synth.
DR   InterPro; IPR020560; PRibGlycinamide_synth_C-dom.
DR   InterPro; IPR020559; PRibGlycinamide_synth_CS.
DR   InterPro; IPR020562; PRibGlycinamide_synth_N.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   Pfam; PF01071; GARS_A; 1.
DR   Pfam; PF02843; GARS_C; 1.
DR   Pfam; PF02844; GARS_N; 1.
DR   SUPFAM; SSF51246; SSF51246; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   TIGRFAMs; TIGR00877; purD; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS00184; GARS; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00138};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006735};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_00138, ECO:0000313|EMBL:AAW73791.1};
KW   Magnesium {ECO:0000256|HAMAP-Rule:MF_00138};
KW   Manganese {ECO:0000256|HAMAP-Rule:MF_00138};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00138};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00138};
KW   Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00138};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006735}.
FT   DOMAIN      109    316       ATP-grasp. {ECO:0000256|HAMAP-Rule:
FT                                MF_00138}.
FT   NP_BIND     135    196       ATP. {ECO:0000256|HAMAP-Rule:MF_00138}.
FT   METAL       286    286       Magnesium or manganese.
FT                                {ECO:0000256|HAMAP-Rule:MF_00138}.
FT   METAL       288    288       Magnesium or manganese.
FT                                {ECO:0000256|HAMAP-Rule:MF_00138}.
SQ   SEQUENCE   429 AA;  44668 MW;  151A5522BFFF3F59 CRC64;
     MKILVIGSGG REHALAWKIA QSAHVSEVLV APGNAGTATE AKCHNVAVKV NDLEGLLALA
     QREAVALTVV GPEVPLVLGV VDRFHAAGLR IFGPTAKAAQ LEGSKAFAKD FLARHGIPTA
     YYAVHTDVDA ALAYVREKGA PIVVKADGLA AGKGVIVATT LAEAEDAVRD MLSGNAFGDA
     GARVVIEEFL DGEEASFISM VDGTHALPMA TSQDHKRVGD GDTGPNTGGM GAYSPAPVVT
     PEVHARVMRE VVEPTVQGMI ADGVPFTGFL YAGLMIDAHG APKVIEFNVR FGDPETQPVM
     LRLQSDLVDL LNAAIDGKLD SAQAQWDPRP SLGVVIAAKP YPETPVTGEV ITGLDAVPAS
     AKVFHAGTAL NAAGEVVSAG GRVLCVAALG DSVHDAQRTA YAGLQPIHWP SAFQRSDIGW
     RAIARERDQ
//
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