ID Q5KDF2_CRYNJ Unreviewed; 504 AA.
AC Q5KDF2;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=Alpha-amylase, putative {ECO:0000313|EMBL:AAW44866.1};
GN OrderedLocusNames=CNG04200 {ECO:0000313|EMBL:AAW44866.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW44866.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW44866.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 13 family.
CC {ECO:0000256|ARBA:ARBA00008061}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE017347; AAW44866.1; -; Genomic_DNA.
DR RefSeq; XP_572173.1; XM_572173.1.
DR AlphaFoldDB; Q5KDF2; -.
DR STRING; 214684.Q5KDF2; -.
DR CAZy; GH13; Glycoside Hydrolase Family 13.
DR PaxDb; 214684-Q5KDF2; -.
DR EnsemblFungi; AAW44866; AAW44866; CNG04200.
DR GeneID; 3258674; -.
DR KEGG; cne:CNG04200; -.
DR VEuPathDB; FungiDB:CNG04200; -.
DR eggNOG; KOG0471; Eukaryota.
DR HOGENOM; CLU_024572_2_0_1; -.
DR InParanoid; Q5KDF2; -.
DR OMA; CVVIMSN; -.
DR OrthoDB; 2728918at2759; -.
DR Proteomes; UP000002149; Chromosome 7.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd11318; AmyAc_bac_fung_AmyA; 1.
DR Gene3D; 2.40.30.140; -; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR013776; A-amylase_thermo.
DR InterPro; IPR015237; Alpha-amylase_C_pro.
DR InterPro; IPR006047; Glyco_hydro_13_cat_dom.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR43447; ALPHA-AMYLASE; 1.
DR PANTHER; PTHR43447:SF49; ALPHA-AMYLASE; 1.
DR Pfam; PF09154; Alpha-amy_C_pro; 1.
DR Pfam; PF00128; Alpha-amylase; 1.
DR PIRSF; PIRSF001021; Alph-amls_thrmst; 1.
DR SMART; SM00642; Aamy; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002149}.
FT DOMAIN 16..403
FT /note="Glycosyl hydrolase family 13 catalytic"
FT /evidence="ECO:0000259|SMART:SM00642"
SQ SEQUENCE 504 AA; 57327 MW; 4A6ADD8FB65FD65A CRC64;
MAHHANEDHH GKPGNFTMMQ YFEWYAEGGG VHWKKYESES ERLANMGITA CWIPPPTKGS
SPKGTGYDIY DVWDLGEFDQ KGSVGTKWGT KEDLLKAIKA ASEKGIITYI DAVLNHKAGA
DDKEEFMATM VDENNRNKEV GEMHNIEGWT KFTFPGRGDK YSDMKWNFNH FTGVDYDAKT
ETTAIFKIQG DGKHWATDVD KENGSFDYLM FADIDHSHPD VEAELNKWGK WVLQETGAYG
FRFDAVKHIS QSFIAQFVKQ LREGENSKTK AFCVGEFWHD SVDALEAYLD GLGTQFSCFD
SCLQDNFHQA GEARENYDLR KIFDDSLVQR RPLDAVTLVD NHDTQIGQSL ERWVSSAFKP
LAYALILLRV DGYPCVFYGD LYGCGGENPQ EPMNQLEDIV RCRKLFAHGE LRDYWDHPNC
LAWVRVGDEE HDGCVVVICN GKDDGSKRCE VGVEHKGEKW TDVLGWHQGE VTIGDDGWAE
FYSPPESISI WTKVDARGRD EFQK
//
