ID   Q5KEX3_CRYNJ            Unreviewed;       506 AA.
AC   Q5KEX3; Q55R97;
DT   15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2005, sequence version 1.
DT   27-MAR-2024, entry version 114.
DE   SubName: Full=Aldehyde dehydrogenase (Alddh), putative {ECO:0000313|EMBL:AAW44041.1};
GN   OrderedLocusNames=CNF03900 {ECO:0000313|EMBL:AAW44041.1};
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW44041.1, ECO:0000313|Proteomes:UP000002149};
RN   [1] {ECO:0000313|EMBL:AAW44041.1, ECO:0000313|Proteomes:UP000002149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; AE017346; AAW44041.1; -; Genomic_DNA.
DR   RefSeq; XP_571348.1; XM_571348.1.
DR   AlphaFoldDB; Q5KEX3; -.
DR   STRING; 214684.Q5KEX3; -.
DR   PaxDb; 214684-Q5KEX3; -.
DR   EnsemblFungi; AAW44041; AAW44041; CNF03900.
DR   GeneID; 3258063; -.
DR   KEGG; cne:CNF03900; -.
DR   VEuPathDB; FungiDB:CNF03900; -.
DR   eggNOG; KOG2450; Eukaryota.
DR   HOGENOM; CLU_005391_0_1_1; -.
DR   InParanoid; Q5KEX3; -.
DR   OMA; HGIGYYP; -.
DR   OrthoDB; 216092at2759; -.
DR   Proteomes; UP000002149; Chromosome 6.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IBA:GO_Central.
DR   CDD; cd07143; ALDH_AldA_AN0554; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR11699:SF211; ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1; 1.
DR   PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003345};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002149}.
FT   DOMAIN          35..494
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        271
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   506 AA;  54957 MW;  3DB403EDC8E08768 CRC64;
     MAPTFTHEFN HAGYKGKVEV PTGIFINGEW ASSVDKNAKT IDVYNPTTGE VLTKIPEALE
     ADVNKAVEVA HNAFNNSWGL SVPGFKRGEY LIKIAELMER DLDILASLEA LDNGKTFGAA
     KGFDVIESAR TFRYYGGWAD KIHGKVIETS SSKLTYTLHE PVGVCGQIIP WNFPLLMFSW
     KIAPALAAGN TVVIKPSELT PLTAMYMTKL FNEAGLPKGV INVVVGYGQT VGNALAGHPA
     IDKVAFTGST AVGRKVMEEA SKSNIKKVTL ELGGKSANIV FEDADFEEAV KYSAQGIFFN
     HGQTCCAGSR IYVQKPIYEK FVKAFKEQTS KLKVGDPFDP NTYQGPQVSQ IQAERIMSYV
     DHGKQEGATV ITGGKRCGDK GYFIEPTVFG DVTANMKIVK EEIFGPVVVV SPFETEEEAL
     EHANDSVYGL ASAVFTSNIS RATRVASKLK AGTVWINCYN ELHPQVPFGG FKQSGLGREL
     GEYALENYTE IKAVQINVGA KCAIPT
//