ID Q5RB43_PONAB Unreviewed; 709 AA.
AC Q5RB43;
DT 21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 21-DEC-2004, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
GN Name=DKFZp469O2418 {ECO:0000313|EMBL:CAH91017.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|EMBL:CAH91017.1};
RN [1] {ECO:0000313|EMBL:CAH91017.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Kidney {ECO:0000313|EMBL:CAH91017.1};
RG The German cDNA Consortium;
RA Ottenwaelder B., Obermaier B., Deutschenbaur S., Schaipp A., Mewes H.W.,
RA Weil B., Amid C., Osanger A., Fobo G., Han M., Wiemann S.;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
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DR EMBL; CR858812; CAH91017.1; -; mRNA.
DR RefSeq; NP_001125587.1; NM_001132115.1.
DR AlphaFoldDB; Q5RB43; -.
DR GeneID; 100172503; -.
DR KEGG; pon:100172503; -.
DR CTD; 23385; -.
DR OrthoDB; 1330770at2759; -.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0006509; P:membrane protein ectodomain proteolysis; ISS:UniProtKB.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0043085; P:positive regulation of catalytic activity; ISS:UniProtKB.
DR GO; GO:0016485; P:protein processing; ISS:UniProtKB.
DR CDD; cd03881; M28_Nicastrin; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR041084; Ncstrn_small.
DR InterPro; IPR008710; Nicastrin.
DR PANTHER; PTHR21092; NICASTRIN; 1.
DR PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR Pfam; PF18266; Ncstrn_small; 1.
DR Pfam; PF05450; Nicastrin; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..709
FT /note="Nicastrin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004261299"
FT TRANSMEM 670..690
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 49..223
FT /note="Nicastrin small lobe"
FT /evidence="ECO:0000259|Pfam:PF18266"
SQ SEQUENCE 709 AA; 78541 MW; A83C2EC65BA52294 CRC64;
MATAGGGSGA DPGSRGLLRL LSFSVLLAGL CRGNSVERKI YIPLNKTAPC VRLLNATHQI
GCQSSISGDT GVIHVLEKEE DLQWVLTDGP NPPYMVLLES KHFTRDLMEK LKGRTSRIAG
LAVSLTKPSP ASGFSPSVQC PNDGFGVYSN SYGPEFAHCR EIQWNSLGNG LAYEDFSFPI
FLLEDENETK VIKQCYQDHD LSQNGSTPTF PLCAMQLFSH MHAVISTATC MRRSSIQSTF
SINPEIVCDP LSDYNVWSML KPINTTGTLK PDDRVVVAAT RLDSRSFFWN VAPGAESAVA
SFVTQLAAAE ALQKAPDVTT LPRNVMFVFF QGETFDYIGS SRMVYDMEKG KFPVQLENVD
SFVELGQVAL RTSLELWMHT DPVSQKNESV RNQVEDLLAT LEKSGAGVPA VILRRPNQSQ
PLPPSSLQRF LRARNISGVV LADHSGAFHN KYYQSIYDTA ENINVSYPEW LSPEEDLNFV
TDTAKALADV ATVLGRALYE LAGGTNFSDR VQADPQTVTR LLYGFLIKAN NSWFQSILRQ
DLRSYLGDGP LQHYIAVSSP TNTTYVVQYA LANLTGTVVN LTREQCQDPS KVPSENKDLY
EYSWVQGPLH SNETDRLPRC VRSTARLARA LSPAFELSQW SSTEYSTWTE SRWKDIRARI
FLIASKELEF ITLIVGFGIL IFSLVITYCI NAKADVLFIA PREPGAVSY
//
