ID Q5ZK99_CHICK Unreviewed; 709 AA.
AC Q5ZK99;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 08-NOV-2023, entry version 106.
DE RecName: Full=Transglutaminase-like domain-containing protein {ECO:0000259|SMART:SM00460};
GN ORFNames=RCJMB04_12c19 {ECO:0000313|EMBL:CAG31844.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:CAG31844.1};
RN [1] {ECO:0000313|EMBL:CAG31844.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CB {ECO:0000313|EMBL:CAG31844.1};
RC TISSUE=Bursa {ECO:0000313|EMBL:CAG31844.1};
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|PIRSR:PIRSR000459-2};
CC Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR000459-2};
CC -!- SIMILARITY: Belongs to the transglutaminase superfamily.
CC Transglutaminase family. {ECO:0000256|ARBA:ARBA00005968}.
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DR EMBL; AJ720185; CAG31844.1; -; mRNA.
DR RefSeq; NP_001006368.1; NM_001006368.1.
DR AlphaFoldDB; Q5ZK99; -.
DR GeneID; 420706; -.
DR KEGG; gga:420706; -.
DR CTD; 7047; -.
DR VEuPathDB; HostDB:geneid_420706; -.
DR PhylomeDB; Q5ZK99; -.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR002931; Transglutaminase-like.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR InterPro; IPR023608; Transglutaminase_animal.
DR InterPro; IPR013808; Transglutaminase_AS.
DR InterPro; IPR008958; Transglutaminase_C.
DR InterPro; IPR036238; Transglutaminase_C_sf.
DR InterPro; IPR001102; Transglutaminase_N.
DR PANTHER; PTHR11590; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE; 1.
DR PANTHER; PTHR11590:SF70; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 4; 1.
DR Pfam; PF00927; Transglut_C; 1.
DR Pfam; PF01841; Transglut_core; 1.
DR Pfam; PF00868; Transglut_N; 1.
DR PIRSF; PIRSF000459; TGM_EBP42; 1.
DR SMART; SM00460; TGc; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49309; Transglutaminase, two C-terminal domains; 2.
DR PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE 2: Evidence at transcript level;
KW Calcium {ECO:0000256|PIRSR:PIRSR000459-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2}.
FT DOMAIN 259..352
FT /note="Transglutaminase-like"
FT /evidence="ECO:0000259|SMART:SM00460"
FT ACT_SITE 267
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 326
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 349
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT BINDING 389
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 391
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 441
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 446
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
SQ SEQUENCE 709 AA; 78967 MW; 271D228BFE9BC064 CRC64;
MSQDSDLKVT KVDFLKSQNS VQHHTDAYNT SNLVVRRGQP FLLQLTLSRE LRAADKLSLH
FSIGERPMEP TGTLMSLNPR STRNVSGWQI AIIKSSGTEC TLSVTSAPNA AVGIYGLMVK
TGPNIYKPEK NTVYLLFNPW GEGDIVFLSN EAERKEYVLN DTGYIYVGSA FNIHSKPWNF
GQFEESILDA CMYLLDKSKL KMSSRRDPVV VSRAMSALVN ANDDNGVVLG NWSGKYENGT
SPMAWIGSVA ILQQYYKTKK PVSYGQCWVF SGVLTTVMRC LGIPARSVSN FNSAHDTDEN
LRVDVYLNEK GEKLKWMSSD SVWNFHVWND VWMKRKDLPS GFDGWQAIDA TPQEQSQGTF
QCGPCPLKAV KEGDVYLPYD SKFVYAEVNA DKVYWRVKEE NGRNKYTKLG VESQSIGANI
STKAVGQNRR EDITWQYKFP EGSAEERASM KRAVSYLQPS GLTPRSRFAA VPMEVSLRNV
SDKDTVQNEV VPKSGVQLEI TNEKPLCPGN PIEVTITVKS TVAGSWTVDL ASSCQLQSYT
GKVHANLGYI KQTVKVEGQS EVHVPLKIMP DAYMKALATV DDEEHVHVTA IAEIQGTPEK
LTKEASLSFE YPPIQVQMPE TAKVNNDFTC AFIFKNKLNV PLDNCKLMVE GLGIFKMATF
DEGDIQPGRI IKSEVICTPT RVGEKKIVAR LTSNQVKDIS VEKAITVTH
//