ID Q5ZTD3_LEGPH Unreviewed; 581 AA.
AC Q5ZTD3;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Saframycin Mx1 synthetase B {ECO:0000313|EMBL:AAU28294.1};
GN OrderedLocusNames=lpg2229 {ECO:0000313|EMBL:AAU28294.1};
OS Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC
OS 33152 / DSM 7513).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=272624 {ECO:0000313|EMBL:AAU28294.1, ECO:0000313|Proteomes:UP000000609};
RN [1] {ECO:0000313|EMBL:AAU28294.1, ECO:0000313|Proteomes:UP000000609}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Philadelphia 1 / ATCC 33152 / DSM 7513
RC {ECO:0000313|Proteomes:UP000000609};
RX PubMed=15448271; DOI=10.1126/science.1099776;
RA Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G.,
RA Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V.,
RA Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S., Georghiou A.,
RA Chou I.C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A.,
RA Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A.,
RA Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A.,
RA Russo J.J.;
RT "The genomic sequence of the accidental pathogen Legionella pneumophila.";
RL Science 305:1966-1968(2004).
RN [2] {ECO:0007829|PDB:3KXW, ECO:0007829|PDB:3LNV}
RP X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 2-581.
RX PubMed=21185305; DOI=10.1016/j.jmb.2010.12.011;
RA Zhang Z., Zhou R., Sauder J.M., Tonge P.J., Burley S.K., Swaminathan S.;
RT "Structural and functional studies of fatty acyl adenylate ligases from E.
RT coli and L. pneumophila.";
RL J. Mol. Biol. 406:313-324(2011).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE017354; AAU28294.1; -; Genomic_DNA.
DR RefSeq; WP_010947938.1; NC_002942.5.
DR RefSeq; YP_096241.1; NC_002942.5.
DR PDB; 3KXW; X-ray; 1.85 A; A=2-581.
DR PDB; 3LNV; X-ray; 2.00 A; A=2-581.
DR PDBsum; 3KXW; -.
DR PDBsum; 3LNV; -.
DR AlphaFoldDB; Q5ZTD3; -.
DR SMR; Q5ZTD3; -.
DR STRING; 272624.lpg2229; -.
DR PaxDb; 272624-lpg2229; -.
DR GeneID; 66491356; -.
DR KEGG; lpn:lpg2229; -.
DR PATRIC; fig|272624.6.peg.2341; -.
DR eggNOG; COG0318; Bacteria.
DR HOGENOM; CLU_000022_23_7_6; -.
DR OrthoDB; 9757559at2; -.
DR EvolutionaryTrace; Q5ZTD3; -.
DR Proteomes; UP000000609; Chromosome.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:InterPro.
DR CDD; cd05931; FAAL; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR040097; FAAL/FAAC.
DR PANTHER; PTHR22754:SF32; DISCO-INTERACTING PROTEIN 2; 1.
DR PANTHER; PTHR22754; DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:3KXW, ECO:0007829|PDB:3LNV};
KW Reference proteome {ECO:0000313|Proteomes:UP000000609}.
FT DOMAIN 21..412
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
SQ SEQUENCE 581 AA; 66038 MW; 7072340A7913B292 CRC64;
MKKEYLQCQS LVDVVRLRAL HSPNKKSCTF LNKELEETMT YEQLDQHAKA IAATLQAEGA
KPGDRVLLLF APGLPLIQAF LGCLYAGCIA VPIYPPAQEK LLDKAQRIVT NSKPVIVLMI
ADHIKKFTAD ELNTNPKFLK IPAIALESIE LNRSSSWQPT SIKSNDIAFL QYTSGSTMHP
KGVMVSHHNL LDNLNKIFTS FHMNDETIIF SWLPPHHDMG LIGCILTPIY GGIQAIMMSP
FSFLQNPLSW LKHITKYKAT ISGSPNFAYD YCVKRIREEK KEGLDLSSWV TAFNGAEPVR
EETMEHFYQA FKEFGFRKEA FYPCYGLAEA TLLVTGGTPG SSYKTLTLAK EQFQDHRVHF
ADDNSPGSYK LVSSGNPIQE VKIIDPDTLI PCDFDQVGEI WVQSNSVAKG YWNQPEETRH
AFAGKIKDDE RSAIYLRTGD LGFLHENELY VTGRIKDLII IYGKNHYPQD IEFSLMHSPL
HHVLGKCAAF VIQEEHEYKL TVMCEVKNRF MDDVAQDNLF NEIFELVYEN HQLEVHTIVL
IPLKAMPHTT SGKIRRNFCR KHLLDKTLPI VATWQLNKIE E
//