ID   Q62J89_BURMA            Unreviewed;       530 AA.
AC   Q62J89;
DT   25-OCT-2004, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2004, sequence version 1.
DT   01-MAY-2013, entry version 62.
DE   RecName: Full=Malate synthase;
DE            EC=2.3.3.9;
GN   Name=aceB; OrderedLocusNames=BMA1590;
OS   Burkholderia mallei (strain ATCC 23344).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=243160;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23344;
RX   PubMed=15377793; DOI=10.1073/pnas.0403306101;
RA   Nierman W.C., DeShazer D., Kim H.S., Tettelin H., Nelson K.E.,
RA   Feldblyum T.V., Ulrich R.L., Ronning C.M., Brinkac L.M.,
RA   Daugherty S.C., Davidsen T.D., DeBoy R.T., Dimitrov G., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Haft D.H., Khouri H.M., Kolonay J.F.,
RA   Madupu R., Mohammoud Y., Nelson W.C., Radune D., Romero C.M.,
RA   Sarria S., Selengut J., Shamblin C., Sullivan S.A., White O., Yu Y.,
RA   Zafar N., Zhou L., Fraser C.M.;
RT   "Structural flexibility in the Burkholderia mallei genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14246-14251(2004).
CC   -!- CATALYTIC ACTIVITY: Acetyl-CoA + H(2)O + glyoxylate = (S)-malate +
CC       CoA.
CC   -!- PATHWAY: Carbohydrate metabolism; glyoxylate cycle; (S)-malate
CC       from isocitrate: step 2/2.
CC   -!- SIMILARITY: Belongs to the malate synthase family.
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DR   EMBL; CP000010; AAU48131.1; -; Genomic_DNA.
DR   RefSeq; YP_103230.1; NC_006348.1.
DR   ProteinModelPortal; Q62J89; -.
DR   STRING; 243160.BMA1590; -.
DR   EnsemblBacteria; AAU48131; AAU48131; BMA1590.
DR   GeneID; 3088474; -.
DR   KEGG; bma:BMA1590; -.
DR   PATRIC; 19118238; VBIBurMal55007_1636.
DR   HOGENOM; HOG000238464; -.
DR   KO; K01638; -.
DR   OMA; GFDGTWV; -.
DR   ProtClustDB; PRK09255; -.
DR   UniPathway; UPA00703; UER00720.
DR   GO; GO:0004474; F:malate synthase activity; IEA:EC.
DR   GO; GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR011076; Malate_synth-like.
DR   InterPro; IPR006252; Malate_synthA.
DR   InterPro; IPR001465; Malate_synthase.
DR   InterPro; IPR019830; Malate_synthase_CS.
DR   PANTHER; PTHR21631:SF1; PTHR21631:SF1; 1.
DR   Pfam; PF01274; Malate_synthase; 1.
DR   PIRSF; PIRSF001363; Malate_synth; 1.
DR   SUPFAM; SSF51645; Malat_synth_like; 1.
DR   TIGRFAMs; TIGR01344; malate_syn_A; 1.
DR   PROSITE; PS00510; MALATE_SYNTHASE; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Complete proteome; Glyoxylate bypass; Transferase;
KW   Tricarboxylic acid cycle.
FT   ACT_SITE    165    165       Proton acceptor (By similarity).
FT   ACT_SITE    447    447       Proton donor (By similarity).
SQ   SEQUENCE   530 AA;  59205 MW;  7938AF88E7BDDA45 CRC64;
     MTTTLKLPQG MAITGEIKPG YEAILTPEAL ELVAKLHRQF EPRRRELLAA RVERTQRLDA
     GERPDFLAET KSIREGDWKI APLPADLQCR RVEITGPVER KMIINALNSG ADSYMTDFED
     SNAPSWTNQI DGQINLKDAV RRTISLEQNG KSYKLNDKIA TLIVRPRGWH LDEKHVTVDG
     QRVSGGVFDF ALFLFHNAQE LIARGSGPYF YLPKMESHLE ARLWNDIFVA AQEALGVPRG
     TIRATVLIET ILAAFEMDEI LYELREHSSG LNAGRWDYIF SAIKKFKNDR DFCLADRAKI
     TMTVPFMRAY ALLLLKTCHK RNAPAIGGMS ALIPIKNDPE ANDRAMAGVR ADKARDAGDG
     YDGGWVAHPG LVSLAMEEFV KVLGDKPNQI GKQRDDVQIE GKNLLDFQPE APITEAGLRN
     NINVGIHYLG SWLAGNGCVP IHNLMEDAAT AEISRSQVWQ WIRSPKGTLD DGRKVTAELV
     REYAKVELAN VKQVVGGDTA PYDRAAAIFE QMSTSENFTE FLTLPLYEEI
//