ID Q6D1D5_PECAS Unreviewed; 511 AA.
AC Q6D1D5;
DT 16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE SubName: Full=Multidrug resistance protein B {ECO:0000313|EMBL:CAG76411.1};
GN Name=emrB {ECO:0000313|EMBL:CAG76411.1};
GN OrderedLocusNames=ECA3513 {ECO:0000313|EMBL:CAG76411.1};
OS Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia
OS carotovora subsp. atroseptica).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Pectobacteriaceae; Pectobacterium.
OX NCBI_TaxID=218491 {ECO:0000313|EMBL:CAG76411.1, ECO:0000313|Proteomes:UP000007966};
RN [1] {ECO:0000313|EMBL:CAG76411.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SCRI1043 {ECO:0000313|EMBL:CAG76411.1};
RA Bell K.S., Sebaihia M., Pritchard L., Holden M., Hyman L.J., Holeva M.C.,
RA Thomson N.R., Bentley S.D., Churcher C., Mungall K., Atkin R., Bason N.,
RA Brooks K., Chillingworth T., Clark K., Doggett J., Fraser A., Hance Z.,
RA Hauser H., Jagels K., Moule S., Norbertczak H., Ormond D., Price C.,
RA Quail M.A., Sanders M., Walker D., Whitehead S., Salmond G.P.C.,
RA Birch P.R.J., Barrell B.G., Parkhill J., Toth I.K.;
RT "The genome sequence of the enterobacterial phytopathogen Erwinia
RT carotovora subsp. atroseptica SCRI1043 and functional genomic
RT identification of novel virulence factors.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. EmrB family.
CC {ECO:0000256|ARBA:ARBA00008537}.
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DR EMBL; BX950851; CAG76411.1; -; Genomic_DNA.
DR RefSeq; WP_011095018.1; NC_004547.2.
DR AlphaFoldDB; Q6D1D5; -.
DR STRING; 218491.ECA3513; -.
DR GeneID; 57210181; -.
DR KEGG; eca:ECA3513; -.
DR PATRIC; fig|218491.5.peg.3559; -.
DR eggNOG; COG2814; Bacteria.
DR HOGENOM; CLU_000960_28_0_6; -.
DR OrthoDB; 9812221at2; -.
DR Proteomes; UP000007966; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17503; MFS_LmrB_MDR_like; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR Gene3D; 1.20.1720.10; Multidrug resistance protein D; 1.
DR InterPro; IPR004638; EmrB-like.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR NCBIfam; TIGR00711; efflux_EmrB; 1.
DR PANTHER; PTHR42718:SF47; DRUG EFFLUX PUMP JEFA; 1.
DR PANTHER; PTHR42718; MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007966};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..511
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004271777"
FT TRANSMEM 50..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 80..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 105..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 479..497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..502
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
SQ SEQUENCE 511 AA; 55559 MW; 4E70B2D59E838BBB CRC64;
MQRKPLKGAS LAWMTVALSL ATFMQVLDST IANVAIPTIA GNLGASNSQG TWVITSFGVA
NAISIPITGW LAKRFGEVRL FLWSTALFAL TSWLCGMSTS LEMLIFARVL QGIVAGPLIP
LSQSLLLSNY PPAKRSIALA LWSMTVVVAP ICGPILGGWI SDNYHWGWIF FINVPLGIAV
VFIALQTLRG RETKTEIKPI DTIGLALLVV GIGSLQMMLD RGKELDWFNS TEIITLTVVA
VIAITFLIVW ELTDDHPVVD LSLFKSRNFT IGCLCISLAY MFYFGAIVLL PQLLQEVYGY
TATWAGLASA PVGLMPVLLS PIIGRFAPRL DMRKLVTFSF IMYAVCFYWR AYTFEPGMDF
GASAWPQFVQ GFAVACFFMP LTTITLSGLP PERLAAASSL SNFARTLAGS IGTSLTTTLW
TQRESLHHAH LTESITPYNP IAQETYQQLQ AMGMSQTQAS AYIAEQITAQ GLIISANEIF
WAAAAVFLVL LVLVWFARPP FTTGGGGGGA H
//
