ID   Q6KZW6_PICTO            Unreviewed;       334 AA.
AC   Q6KZW6;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 125.
DE   SubName: Full=Zinc-binding dehydrogenase {ECO:0000313|EMBL:AAT43736.1};
GN   OrderedLocusNames=PTO1151 {ECO:0000313|EMBL:AAT43736.1};
OS   Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC
OS   100828 / KAW 2/3).
OC   Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC   Picrophilaceae; Picrophilus.
OX   NCBI_TaxID=1122961 {ECO:0000313|EMBL:AAT43736.1, ECO:0000313|Proteomes:UP000000438};
RN   [1] {ECO:0000313|EMBL:AAT43736.1, ECO:0000313|Proteomes:UP000000438}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828
RC   {ECO:0000313|Proteomes:UP000000438};
RX   PubMed=15184674; DOI=10.1073/pnas.0401356101;
RA   Futterer O., Angelov A., Liesegang H., Gottschalk G., Schleper C.,
RA   Schepers B., Dock C., Antranikian G., Liebl W.;
RT   "Genome sequence of Picrophilus torridus and its implications for life
RT   around pH 0.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9091-9096(2004).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
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DR   EMBL; AE017261; AAT43736.1; -; Genomic_DNA.
DR   RefSeq; WP_011177952.1; NC_005877.1.
DR   AlphaFoldDB; Q6KZW6; -.
DR   STRING; 263820.PTO1151; -.
DR   PaxDb; 263820-PTO1151; -.
DR   GeneID; 2845129; -.
DR   KEGG; pto:PTO1151; -.
DR   eggNOG; arCOG01455; Archaea.
DR   HOGENOM; CLU_026673_11_0_2; -.
DR   InParanoid; Q6KZW6; -.
DR   OrthoDB; 8709at2157; -.
DR   Proteomes; UP000000438; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd08259; Zn_ADH5; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR42940; ALCOHOL DEHYDROGENASE 1-RELATED; 1.
DR   PANTHER; PTHR42940:SF8; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Zinc {ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          8..330
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   334 AA;  36571 MW;  523F11978CED032C CRC64;
     MKAAFLKKLN SELEIDDIEE PEPGDDEVVI EQRYTGICYR DILTMQGFQP RVNIPVIPGH
     EISGRIIKKG KNVESFNINE RVSSLIYIPC GKCEFCLSGN ENLCVNKRIF GESVNGAYRK
     YINVNMNSLV HVPDNVPEES SVIAACVTGM IIHALRLGNI SEKKTVLITG AGGGVGMHAI
     EIAKTYGATV IAETTSEWKK KAIYEAGADY VVSGSYSKDV KNYGGADIVL EIVGKDTFNE
     SLRSLKTGGS LVLIGNVRPA SAEMPIGLII MKGNRIIGSL SSTRKDVSEA LQLSSEKRIS
     PRIFDKVSLN DVNRAFDDMI NKRNNGRILI DLNK
//