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Database: UniProt/TrEMBL
Entry: Q72AX3_DESVH
LinkDB: Q72AX3_DESVH
Original site: Q72AX3_DESVH 
ID   Q72AX3_DESVH            Unreviewed;       282 AA.
AC   Q72AX3;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   19-MAR-2014, entry version 76.
DE   RecName: Full=Diaminopimelate epimerase;
DE            Short=DAP epimerase;
DE            EC=5.1.1.7;
GN   Name=dapF; OrderedLocusNames=DVU_1867;
OS   Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB
OS   8303).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Desulfovibrio.
OX   NCBI_TaxID=882;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hildenborough / ATCC 29579 / NCIMB 8303;
RX   PubMed=15077118; DOI=10.1038/nbt959;
RA   Heidelberg J.F., Seshadri R., Haveman S.A., Hemme C.L., Paulsen I.T.,
RA   Kolonay J.F., Eisen J.A., Ward N.L., Methe B.A., Brinkac L.M.,
RA   Daugherty S.C., DeBoy R.T., Dodson R.J., Durkin A.S., Madupu R.,
RA   Nelson W.C., Sullivan S.A., Fouts D.E., Haft D.H., Selengut J.,
RA   Peterson J.D., Davidsen T.M., Zafar N., Zhou L., Radune D.,
RA   Dimitrov G., Hance M., Tran K., Khouri H.M., Gill J., Utterback T.R.,
RA   Feldblyum T.V., Wall J.D., Voordouw G., Fraser C.M.;
RT   "The genome sequence of the anaerobic, sulfate-reducing bacterium
RT   Desulfovibrio vulgaris Hildenborough.";
RL   Nat. Biotechnol. 22:554-559(2004).
CC   -!- FUNCTION: Catalyzes the stereoinversion of LL-2,6-
CC       diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-
CC       DAP), a precursor of L-lysine and an essential component of the
CC       bacterial peptidoglycan (By similarity).
CC   -!- CATALYTIC ACTIVITY: LL-2,6-diaminoheptanedioate = meso-
CC       diaminoheptanedioate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC       pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step
CC       1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the diaminopimelate epimerase family.
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DR   EMBL; AE017285; AAS96343.1; -; Genomic_DNA.
DR   RefSeq; YP_011084.1; NC_002937.3.
DR   ProteinModelPortal; Q72AX3; -.
DR   STRING; 882.DVU1867; -.
DR   EnsemblBacteria; AAS96343; AAS96343; DVU_1867.
DR   GeneID; 2794311; -.
DR   KEGG; dvu:DVU1867; -.
DR   PATRIC; 32063474; VBIDesVul119526_1710.
DR   eggNOG; COG0253; -.
DR   KO; K01778; -.
DR   OMA; CFARFVL; -.
DR   OrthoDB; EOG6ND0M5; -.
DR   ProtClustDB; PRK00450; -.
DR   BioCyc; DVUL882:GJIL-1910-MONOMER; -.
DR   UniPathway; UPA00034; UER00025.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008837; F:diaminopimelate epimerase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_00197; DAP_epimerase; 1.
DR   InterPro; IPR018510; DAP_epimerase_AS.
DR   InterPro; IPR001653; DAP_epimerase_DapF.
DR   PANTHER; PTHR31689:SF0; PTHR31689:SF0; 1.
DR   Pfam; PF01678; DAP_epimerase; 2.
DR   TIGRFAMs; TIGR00652; DapF; 1.
DR   PROSITE; PS01326; DAP_EPIMERASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm; Disulfide bond;
KW   Isomerase; Lysine biosynthesis; Reference proteome.
FT   REGION       83     85       Substrate binding (By similarity).
FT   REGION      208    209       Substrate binding (By similarity).
FT   REGION      219    220       Substrate binding (By similarity).
FT   ACT_SITE     83     83       Proton donor/acceptor (By similarity).
FT   ACT_SITE    218    218       Proton donor/acceptor (By similarity).
FT   BINDING      18     18       Substrate (By similarity).
FT   BINDING      53     53       Substrate (By similarity).
FT   BINDING      74     74       Substrate (By similarity).
FT   BINDING     190    190       Substrate (By similarity).
FT   SITE        158    158       Important for catalytic activity (By
FT                                similarity).
FT   SITE        208    208       Important for catalytic activity (By
FT                                similarity).
FT   DISULFID     83    218       Size: 249-333 (By similarity).
SQ   SEQUENCE   282 AA;  29964 MW;  FC53A0F1844E88E4 CRC64;
     MSGKKATVPF HKLHGCGNDF VFIDNRHLKL SVEAMPDWAR SICRRAFGVG ADGLVFLDTA
     PQGHEADYIW HFYNADGSRA EMCGNASRCA AVLAVDLGFA GPRHAFGTDA GIVHAVADVE
     AGYAKVELTR PRDLAAGTTL ELEGTPFTVH FVNTGVPHAV VFSDSVDGLD LRRLGAALRY
     HPHFSPAGTN ANFASIIDRR TIHLRTYERG VEDETYACGT GAAATAFIAH TLGLTDASVG
     VRTSGGEVLG IDIEDGSIFL SGKAVRVFSG EMHPEGLGLT LP
//
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