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Database: UniProt/TrEMBL
Entry: Q72H23_THET2
LinkDB: Q72H23_THET2
Original site: Q72H23_THET2 
ID   Q72H23_THET2            Unreviewed;       337 AA.
AC   Q72H23;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   26-NOV-2014, entry version 87.
DE   RecName: Full=Cytochrome c oxidase subunit 2 {ECO:0000256|RuleBase:RU004024};
DE            EC=1.9.3.1 {ECO:0000256|RuleBase:RU004024};
GN   OrderedLocusNames=TT_C1672 {ECO:0000313|EMBL:AAS82014.1};
OS   Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039).
OC   Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae;
OC   Thermus.
OX   NCBI_TaxID=262724 {ECO:0000313|EMBL:AAS82014.1, ECO:0000313|Proteomes:UP000000592};
RN   [1] {ECO:0000313|EMBL:AAS82014.1, ECO:0000313|Proteomes:UP000000592}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HB27 / ATCC BAA-163 / DSM 7039
RC   {ECO:0000313|Proteomes:UP000000592};
RX   PubMed=15064768; DOI=10.1038/nbt956;
RA   Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T.,
RA   Liesegang H., Johann A., Lienard T., Gohl O., Martinez-Arias R.,
RA   Jacobi C., Starkuviene V., Schlenczeck S., Dencker S., Huber R.,
RA   Klenk H.-P., Kramer W., Merkl R., Gottschalk G., Fritz H.-J.;
RT   "The genome sequence of the extreme thermophile Thermus
RT   thermophilus.";
RL   Nat. Biotechnol. 22:547-553(2004).
CC   -!- FUNCTION: Subunits I and II form the functional core of the enzyme
CC       complex. Electrons originating in cytochrome c are transferred via
CC       heme a and Cu(A) to the binuclear center formed by heme a3 and
CC       Cu(B). {ECO:0000256|RuleBase:RU004024}.
CC   -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4
CC       ferricytochrome c + 2 H(2)O. {ECO:0000256|RuleBase:RU004024}.
CC   -!- COFACTOR:
CC       Note=Copper A. {ECO:0000256|RuleBase:RU004024};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU000456};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU000456}.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 2 family.
CC       {ECO:0000256|RuleBase:RU000456}.
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DR   EMBL; AE017221; AAS82014.1; -; Genomic_DNA.
DR   RefSeq; YP_005641.1; NC_005835.1.
DR   ProteinModelPortal; Q72H23; -.
DR   EnsemblBacteria; AAS82014; AAS82014; TT_C1672.
DR   GeneID; 2776061; -.
DR   KEGG; tth:TTC1672; -.
DR   PATRIC; 23953797; VBITheThe54392_1669.
DR   eggNOG; COG2857; -.
DR   KO; K02275; -.
DR   OMA; SYSWLPP; -.
DR   OrthoDB; EOG6S52JN; -.
DR   BioCyc; TTHE262724:GCAT-1705-MONOMER; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0022900; P:electron transport chain; IEA:InterPro.
DR   Gene3D; 1.10.287.90; -; 1.
DR   Gene3D; 1.10.760.10; -; 1.
DR   Gene3D; 2.60.40.420; -; 1.
DR   InterPro; IPR001505; Copper_CuA.
DR   InterPro; IPR008972; Cupredoxin.
DR   InterPro; IPR009056; Cyt_c-like_dom.
DR   InterPro; IPR003088; Cyt_c_dom.
DR   InterPro; IPR014222; Cyt_c_oxidase_su2.
DR   InterPro; IPR002429; Cyt_c_oxidase_su2_C.
DR   InterPro; IPR011759; Cyt_c_oxidase_su2_TM_dom.
DR   Pfam; PF00116; COX2; 1.
DR   Pfam; PF02790; COX2_TM; 1.
DR   Pfam; PF00034; Cytochrom_C; 1.
DR   SUPFAM; SSF46626; SSF46626; 1.
DR   SUPFAM; SSF49503; SSF49503; 1.
DR   SUPFAM; SSF81464; SSF81464; 1.
DR   TIGRFAMs; TIGR02866; CoxB; 1.
DR   PROSITE; PS00078; COX2; 1.
DR   PROSITE; PS50857; COX2_CUA; 1.
DR   PROSITE; PS50999; COX2_TM; 1.
DR   PROSITE; PS51007; CYTC; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000592};
KW   Copper {ECO:0000256|RuleBase:RU004024};
KW   Electron transport {ECO:0000256|RuleBase:RU000456};
KW   Membrane {ECO:0000256|RuleBase:RU000456};
KW   Metal-binding {ECO:0000256|RuleBase:RU004024};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000456,
KW   ECO:0000313|EMBL:AAS82014.1};
KW   Respiratory chain {ECO:0000256|RuleBase:RU000456};
KW   Transmembrane {ECO:0000256|RuleBase:RU000456};
KW   Transport {ECO:0000256|RuleBase:RU000456}.
SQ   SEQUENCE   337 AA;  37271 MW;  E527F9588FF8BF60 CRC64;
     MQRSFAALGL WGLSLAQEAH RVAITHPGGS FNQEVAFLFP WVYFFSFLIF LVVAGSLAYV
     TWKFRARPED QEEPPQIHGN DRLEVVWTLI PLAIVLVLFG LTAKALIQVN RPIPGALKVE
     VTGYQFWWDF HYPELGLRNS NELVLPAGVP VELEITSKDV IHSFWVPGLS GKRDAIPGQT
     TRISFEPKEP GLYYGFCAEL CGASHARMLF RVVVLPKEEF DRFVEQAKAS PAPVADERGQ
     QVFQQNCAAC HGVARSMPPA VIGPELGLLG NRTSLGAGIV ENTPENLKAW IRDPAGMKPG
     VKMPGFPQLS EEDLDALARY LEGLKVEGFD FGALPKF
//
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