ID Q7CJG9_YERPE Unreviewed; 292 AA.
AC Q7CJG9; Q74SH0;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 01-MAY-2013, entry version 63.
DE RecName: Full=Cysteine synthase;
DE EC=2.5.1.47;
GN Name=cysM; Synonyms=cysM1; OrderedLocusNames=y1470, YP_2635, YPO3011;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis, and CO92;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G.,
RA Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V.,
RA Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M.,
RA Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM, and KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/JB.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C.,
RA Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V.,
RA Straley S.C., McDonough K.A., Nilles M.L., Matson J.S., Blattner F.R.,
RA Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CO92;
RX PubMed=12834539; DOI=10.1186/1471-2180-3-13;
RA Delihas N.;
RT "Annotation and evolutionary relationships of a small regulatory RNA
RT gene micF and its target ompF in Yersinia species.";
RL BMC Microbiol. 3:13-13(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001, and 91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z.,
RA Jin L., Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J.,
RA Yang H., Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=91001;
RX PubMed=15262951; DOI=10.1128/JB.186.15.5147-5152.2004;
RA Zhou D., Tong Z., Song Y., Han Y., Pei D., Pang X., Zhai J., Li M.,
RA Cui B., Qi Z., Jin L., Dai R., Du Z., Wang J., Guo Z., Wang J.,
RA Huang P., Yang R.;
RT "Genetics of metabolic variations between Yersinia pestis biovars and
RT the proposal of a new biovar, microtus.";
RL J. Bacteriol. 186:5147-5152(2004).
CC -!- CATALYTIC ACTIVITY: O(3)-acetyl-L-serine + H(2)S = L-cysteine +
CC acetate.
CC -!- SIMILARITY: Belongs to the cysteine synthase/cystathionine beta-
CC synthase family.
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DR EMBL; AE009952; AAM85041.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS62827.1; -; Genomic_DNA.
DR EMBL; AL590842; CAL21614.1; -; Genomic_DNA.
DR PIR; AC0366; AC0366.
DR RefSeq; NP_668790.1; NC_004088.1.
DR RefSeq; NP_993950.1; NC_005810.1.
DR RefSeq; YP_002347933.1; NC_003143.1.
DR HSSP; Q9WZD3; 1O58.
DR STRING; 214092.YPO3011; -.
DR DNASU; 1146417; -.
DR EnsemblBacteria; AAM85041; AAM85041; y1470.
DR EnsemblBacteria; AAS62827; AAS62827; YP_2635.
DR GeneID; 1146417; -.
DR GeneID; 1175833; -.
DR GeneID; 2763561; -.
DR KEGG; ype:YPO3011; -.
DR KEGG; ypk:y1470; -.
DR KEGG; ypm:YP_2635; -.
DR HOGENOM; HOG000217394; -.
DR KO; K12339; -.
DR OMA; CEVALRI; -.
DR ProtClustDB; PRK11761; -.
DR GO; GO:0004124; F:cysteine synthase activity; IEA:EC.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006535; P:cysteine biosynthetic process from serine; IEA:InterPro.
DR InterPro; IPR001216; Cys_synth_BS.
DR InterPro; IPR005856; Cys_synthKM.
DR InterPro; IPR005858; CysM.
DR InterPro; IPR001926; Trp_syn_b_sub_like_PLP_eny_SF.
DR Pfam; PF00291; PALP; 1.
DR SUPFAM; SSF53686; PyrdxlP-dep_enz_bsu; 1.
DR TIGRFAMs; TIGR01136; cysKM; 1.
DR TIGRFAMs; TIGR01138; cysM; 1.
DR PROSITE; PS00901; CYS_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Complete proteome; Cysteine biosynthesis;
KW Hydrolase; Reference proteome; Transferase.
SQ SEQUENCE 292 AA; 31279 MW; 569CDEA6B4BE6721 CRC64;
MTTLEHCIGH TPLVKLQRLS QGLNAEIWVK LEGNNPAGSV KDRAALAMIQ QAELRGDIAP
GDVLIEATSG NTGIALAMIA AMKGYHLKLL MPENMSQERQ AAMRAYGAEL ILVSREQGME
GARDLALTMQ ENGEGNVLDQ FNNADNPYAH FTGTGPEIWQ QTAGKVSHFV SSMGTTGTIT
GVSQYLKSQN PQVKVIGLQP AEGSSIPGIR RWSAEYIPGI FRPELVDQVL DITQSVAEQT
MRRLAKEEGI FCGVSSGGAV AGALRIAADN PDAVIVAIIC DRGDRYLSTG VF
//
