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Database: UniProt/TrEMBL
Entry: Q7CJG9_YERPE
LinkDB: Q7CJG9_YERPE
Original site: Q7CJG9_YERPE 
ID   Q7CJG9_YERPE            Unreviewed;       292 AA.
AC   Q7CJG9; Q74SH0;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   09-JUL-2014, entry version 72.
DE   RecName: Full=Cysteine synthase;
DE            EC=2.5.1.47;
GN   Name=cysM; Synonyms=cysM1; OrderedLocusNames=y1470, YP_2635, YPO3011;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis, and CO92;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G.,
RA   Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V.,
RA   Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M.,
RA   Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM, and KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/JB.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C.,
RA   Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V.,
RA   Straley S.C., McDonough K.A., Nilles M.L., Matson J.S., Blattner F.R.,
RA   Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CO92;
RX   PubMed=12834539; DOI=10.1186/1471-2180-3-13;
RA   Delihas N.;
RT   "Annotation and evolutionary relationships of a small regulatory RNA
RT   gene micF and its target ompF in Yersinia species.";
RL   BMC Microbiol. 3:13-13(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001, and 91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z.,
RA   Jin L., Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J.,
RA   Yang H., Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=91001;
RX   PubMed=15262951; DOI=10.1128/JB.186.15.5147-5152.2004;
RA   Zhou D., Tong Z., Song Y., Han Y., Pei D., Pang X., Zhai J., Li M.,
RA   Cui B., Qi Z., Jin L., Dai R., Du Z., Wang J., Guo Z., Wang J.,
RA   Huang P., Yang R.;
RT   "Genetics of metabolic variations between Yersinia pestis biovars and
RT   the proposal of a new biovar, microtus.";
RL   J. Bacteriol. 186:5147-5152(2004).
CC   -!- CATALYTIC ACTIVITY: O(3)-acetyl-L-serine + H(2)S = L-cysteine +
CC       acetate.
CC   -!- COFACTOR: Pyridoxal phosphate (By similarity).
CC   -!- SIMILARITY: Belongs to the cysteine synthase/cystathionine beta-
CC       synthase family.
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DR   EMBL; AE009952; AAM85041.1; -; Genomic_DNA.
DR   EMBL; AE017042; AAS62827.1; -; Genomic_DNA.
DR   EMBL; AL590842; CAL21614.1; -; Genomic_DNA.
DR   PIR; AC0366; AC0366.
DR   RefSeq; NP_668790.1; NC_004088.1.
DR   RefSeq; NP_993950.1; NC_005810.1.
DR   RefSeq; YP_002347933.1; NC_003143.1.
DR   STRING; 214092.YPO3011; -.
DR   DNASU; 1146417; -.
DR   EnsemblBacteria; AAM85041; AAM85041; y1470.
DR   EnsemblBacteria; AAS62827; AAS62827; YP_2635.
DR   GeneID; 1146417; -.
DR   GeneID; 1175833; -.
DR   GeneID; 2763561; -.
DR   KEGG; ype:YPO3011; -.
DR   KEGG; ypk:y1470; -.
DR   KEGG; ypm:YP_2635; -.
DR   HOGENOM; HOG000217394; -.
DR   KO; K12339; -.
DR   OMA; LQMQADG; -.
DR   OrthoDB; EOG6Q2SP8; -.
DR   BioCyc; YPES214092:GKDD-2971-MONOMER; -.
DR   GO; GO:0004124; F:cysteine synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006535; P:cysteine biosynthetic process from serine; IEA:InterPro.
DR   InterPro; IPR001216; Cys_synth_BS.
DR   InterPro; IPR005856; Cys_synthKM.
DR   InterPro; IPR005858; CysM.
DR   InterPro; IPR001926; Trp_syn_b_sub_like_PLP_eny_SF.
DR   Pfam; PF00291; PALP; 1.
DR   SUPFAM; SSF53686; SSF53686; 1.
DR   TIGRFAMs; TIGR01136; cysKM; 1.
DR   TIGRFAMs; TIGR01138; cysM; 1.
DR   PROSITE; PS00901; CYS_SYNTHASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Cysteine biosynthesis;
KW   Hydrolase; Pyridoxal phosphate; Reference proteome; Transferase.
SQ   SEQUENCE   292 AA;  31279 MW;  569CDEA6B4BE6721 CRC64;
     MTTLEHCIGH TPLVKLQRLS QGLNAEIWVK LEGNNPAGSV KDRAALAMIQ QAELRGDIAP
     GDVLIEATSG NTGIALAMIA AMKGYHLKLL MPENMSQERQ AAMRAYGAEL ILVSREQGME
     GARDLALTMQ ENGEGNVLDQ FNNADNPYAH FTGTGPEIWQ QTAGKVSHFV SSMGTTGTIT
     GVSQYLKSQN PQVKVIGLQP AEGSSIPGIR RWSAEYIPGI FRPELVDQVL DITQSVAEQT
     MRRLAKEEGI FCGVSSGGAV AGALRIAADN PDAVIVAIIC DRGDRYLSTG VF
//
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