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Database: UniProt/TrEMBL
Entry: Q7Q1J9_ANOGA
LinkDB: Q7Q1J9_ANOGA
Original site: Q7Q1J9_ANOGA 
ID   Q7Q1J9_ANOGA            Unreviewed;       922 AA.
AC   Q7Q1J9;
DT   15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT   23-OCT-2007, sequence version 3.
DT   27-SEP-2017, entry version 87.
DE   RecName: Full=Angiotensin-converting enzyme {ECO:0000256|RuleBase:RU361144};
DE            EC=3.4.-.- {ECO:0000256|RuleBase:RU361144};
GN   Name=ANCE7 {ECO:0000313|EMBL:EAA14517.3};
GN   Synonyms=1279163 {ECO:0000313|VectorBase:AGAP009757-PA};
GN   ORFNames=AgaP_AGAP009757 {ECO:0000313|EMBL:EAA14517.3};
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=7165 {ECO:0000313|Proteomes:UP000007062};
RN   [1] {ECO:0000313|VectorBase:AGAP009757-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|VectorBase:AGAP009757-PA};
RX   PubMed=9087549; DOI=10.1111/j.1365-2583.1993.tb00131.x;
RA   Beard C.B., Hamm D.M., Collins F.H.;
RT   "The mitochondrial genome of the mosquito Anopheles gambiae: DNA
RT   sequence, genome organization, and comparisons with mitochondrial
RT   sequences of other insects.";
RL   Insect Mol. Biol. 2:103-124(1993).
RN   [2] {ECO:0000313|EMBL:EAA14517.3, ECO:0000313|Proteomes:UP000007062}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA14517.3,
RC   ECO:0000313|Proteomes:UP000007062};
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M., Wides R.,
RA   Salzberg S.L., Loftus B., Yandell M., Majoros W.H., Rusch D.B.,
RA   Lai Z., Kraft C.L., Abril J.F., Anthouard V., Arensburger P.,
RA   Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V.,
RA   Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S.,
RA   Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.,
RA   Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I.,
RA   Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z.,
RA   Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R.,
RA   Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C., Kokoza E.,
RA   Koutsos A., Letunic I., Levitsky A., Liang Y., Lin J.J., Lobo N.F.,
RA   Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.,
RA   Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C.,
RA   Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V.,
RA   Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D.,
RA   Ton L.Q., Topalis P., Tu Z., Unger M.F., Walenz B., Wang A., Wang J.,
RA   Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A.,
RA   Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F.,
RA   Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S.,
RA   Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C.,
RA   Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
RN   [3] {ECO:0000313|EMBL:EAA14517.3}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA14517.3};
RG   The Anopheles Genome Sequencing Consortium;
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:EAA14517.3}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA14517.3};
RX   PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA   Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT   "The Anopheles gambiae genome: an update.";
RL   Trends Parasitol. 20:49-52(2004).
RN   [5] {ECO:0000313|EMBL:EAA14517.3}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA14517.3};
RX   PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA   Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA   Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT   "Update of the Anopheles gambiae PEST genome assembly.";
RL   Genome Biol. 8:R5-R5(2007).
RN   [6] {ECO:0000313|EMBL:EAA14517.3}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA14517.3};
RG   VectorBase;
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|VectorBase:AGAP009757-PA}
RP   IDENTIFICATION.
RC   STRAIN=PEST {ECO:0000313|VectorBase:AGAP009757-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361144};
CC       Note=Binds 1 zinc ion per subunit.
CC       {ECO:0000256|RuleBase:RU361144};
CC   -!- SIMILARITY: Belongs to the peptidase M2 family.
CC       {ECO:0000256|RuleBase:RU361144}.
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DR   EMBL; AAAB01008980; EAA14517.3; -; Genomic_DNA.
DR   RefSeq; XP_318843.3; XM_318843.3.
DR   ProteinModelPortal; Q7Q1J9; -.
DR   STRING; 7165.AGAP009757-PA; -.
DR   PaxDb; Q7Q1J9; -.
DR   EnsemblMetazoa; AGAP009757-RA; AGAP009757-PA; AGAP009757.
DR   GeneID; 1279163; -.
DR   KEGG; aga:AgaP_AGAP009757; -.
DR   VectorBase; AGAP009757-RA; AGAP009757-PA; AGAP009757.
DR   CTD; 1279163; -.
DR   eggNOG; KOG3690; Eukaryota.
DR   eggNOG; ENOG410XPJ3; LUCA.
DR   HOGENOM; HOG000046399; -.
DR   InParanoid; Q7Q1J9; -.
DR   KO; K01283; -.
DR   OMA; ICQASAW; -.
DR   OrthoDB; EOG091G033S; -.
DR   PhylomeDB; Q7Q1J9; -.
DR   Proteomes; UP000007062; Chromosome 3R.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008241; F:peptidyl-dipeptidase activity; IEA:InterPro.
DR   CDD; cd06461; M2_ACE; 1.
DR   InterPro; IPR001548; Peptidase_M2.
DR   PANTHER; PTHR10514; PTHR10514; 1.
DR   Pfam; PF01401; Peptidase_M2; 1.
DR   PRINTS; PR00791; PEPDIPTASEA.
PE   3: Inferred from homology;
KW   Carboxypeptidase {ECO:0000256|RuleBase:RU361144};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007062};
KW   Glycoprotein {ECO:0000256|RuleBase:RU361144};
KW   Hydrolase {ECO:0000256|RuleBase:RU361144};
KW   Metal-binding {ECO:0000256|RuleBase:RU361144};
KW   Metalloprotease {ECO:0000256|RuleBase:RU361144};
KW   Protease {ECO:0000256|RuleBase:RU361144};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007062};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Zinc {ECO:0000256|RuleBase:RU361144}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    922       Angiotensin-converting enzyme.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5010975291.
SQ   SEQUENCE   922 AA;  107563 MW;  6FCF280079F6046F CRC64;
     MLKLLIKCTI GALFALQSIH CEADPQLNLP PLAPPGLEGR RPVTFPNGEA SPTRVPLGVD
     GVVSGDGSSV HDRSRSERFG PPYDGDDDEE DERPNYPAQQ PEGRANDYDR RDRQDSPYSY
     NDRNRYGGDR GYDRNQNRER YPGDRSPNPY VSDVDNPLLY RDGGDRNRNR YVSDVENPLL
     YRDRTPYNPS RDYDDRNRYN PNARPYNPND PSFGGRNPPD PNYRGPGQRD PNYRDQGFRE
     PGQRFPGDDR TRYPDDPNYP YRSPEEERFR IENERRFRAE TEKLRAFLTE IDRKSSLECS
     LNVAAQWNFE TNINDATQVE ALAAQQRYND FQRLLWDQMR RIDQTKIFDD KLYRQVRLMS
     IIGPSALPPD QLDRYNRIVN DMLAIFNGAT ICAYEQPFEC GLRLQPHLKD VSEQSIMAKS
     RDWNELQYTW LEWRRKSGRN MRDLFEQLVD LTNDAGRVNN FTDAAAYWTF PYESRNFREE
     MEQVWREILP LYEMIHAYVR RKLREFYGPD KINKNAPLPD HILGDMYGQS WQNILDIVIP
     YPGRSFLEVT PEMQKQGYNP LVMFQIAEEF FVSMNMSAMP PDFWASSIVT QPPDRPILCQ
     PSSWDFCTGK DYRVKMCTQV THKDFITVHH ELAHIQYFLN YRNNPKVFRD GANPGFHEAI
     GDAISLSVAS PKHLQNLGLV QKSVDDTAHD INFLFSLAME KVVFLPFALA LEAWRYDVFS
     KRVRKEQYNC HWWLLREEYG GVKPPVLRSE LDFDPGAKYH VAANIPYIKY FFSNVLQFQI
     YRALCTASGQ YVPQDPSKPL HKCDIYRQPA AGNILKKLME RGTSQPWQQV LQEVIGEGRL
     DGSALREFFR PLEEWLRNEN LRNNEYVGWI YDGDYCKHSI ETANLQVFGG FYNVAVEVQL
     TSWLMLMLSS WLVVMRTFAI VG
//
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