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Database: UniProt/TrEMBL
Entry: Q7Q9W7_ANOGA
LinkDB: Q7Q9W7_ANOGA
Original site: Q7Q9W7_ANOGA 
ID   Q7Q9W7_ANOGA            Unreviewed;      1225 AA.
AC   Q7Q9W7;
DT   15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2007, sequence version 3.
DT   20-DEC-2017, entry version 94.
DE   RecName: Full=Angiotensin-converting enzyme {ECO:0000256|RuleBase:RU361144};
DE            EC=3.4.-.- {ECO:0000256|RuleBase:RU361144};
GN   Name=ANCE9 {ECO:0000313|EMBL:EAA09164.3};
GN   Synonyms=1274704 {ECO:0000313|VectorBase:AGAP004563-PA};
GN   ORFNames=AgaP_AGAP004563 {ECO:0000313|EMBL:EAA09164.3};
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA09164.3, ECO:0000313|Proteomes:UP000007062};
RN   [1] {ECO:0000313|VectorBase:AGAP004563-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|VectorBase:AGAP004563-PA};
RX   PubMed=9087549; DOI=10.1111/j.1365-2583.1993.tb00131.x;
RA   Beard C.B., Hamm D.M., Collins F.H.;
RT   "The mitochondrial genome of the mosquito Anopheles gambiae: DNA
RT   sequence, genome organization, and comparisons with mitochondrial
RT   sequences of other insects.";
RL   Insect Mol. Biol. 2:103-124(1993).
RN   [2] {ECO:0000313|EMBL:EAA09164.3, ECO:0000313|Proteomes:UP000007062}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA09164.3,
RC   ECO:0000313|Proteomes:UP000007062};
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M., Wides R.,
RA   Salzberg S.L., Loftus B., Yandell M., Majoros W.H., Rusch D.B.,
RA   Lai Z., Kraft C.L., Abril J.F., Anthouard V., Arensburger P.,
RA   Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V.,
RA   Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S.,
RA   Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.,
RA   Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I.,
RA   Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z.,
RA   Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R.,
RA   Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C., Kokoza E.,
RA   Koutsos A., Letunic I., Levitsky A., Liang Y., Lin J.J., Lobo N.F.,
RA   Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.,
RA   Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C.,
RA   Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V.,
RA   Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D.,
RA   Ton L.Q., Topalis P., Tu Z., Unger M.F., Walenz B., Wang A., Wang J.,
RA   Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A.,
RA   Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F.,
RA   Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S.,
RA   Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C.,
RA   Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
RN   [3] {ECO:0000313|EMBL:EAA09164.3}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA09164.3};
RG   The Anopheles Genome Sequencing Consortium;
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:EAA09164.3}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA09164.3};
RX   PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA   Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT   "The Anopheles gambiae genome: an update.";
RL   Trends Parasitol. 20:49-52(2004).
RN   [5] {ECO:0000313|EMBL:EAA09164.3}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA09164.3};
RX   PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA   Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA   Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT   "Update of the Anopheles gambiae PEST genome assembly.";
RL   Genome Biol. 8:R5-R5(2007).
RN   [6] {ECO:0000313|EMBL:EAA09164.3}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA09164.3};
RG   VectorBase;
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|VectorBase:AGAP004563-PA}
RP   IDENTIFICATION.
RC   STRAIN=PEST {ECO:0000313|VectorBase:AGAP004563-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361144};
CC       Note=Binds 2 Zn(2+) ions per subunit.
CC       {ECO:0000256|RuleBase:RU361144};
CC   -!- SIMILARITY: Belongs to the peptidase M2 family.
CC       {ECO:0000256|RuleBase:RU361144}.
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DR   EMBL; AAAB01008898; EAA09164.3; -; Genomic_DNA.
DR   RefSeq; XP_313865.3; XM_313865.5.
DR   ProteinModelPortal; Q7Q9W7; -.
DR   STRING; 7165.AGAP004563-PA; -.
DR   PaxDb; Q7Q9W7; -.
DR   EnsemblMetazoa; AGAP004563-RA; AGAP004563-PA; AGAP004563.
DR   GeneID; 1274704; -.
DR   KEGG; aga:AgaP_AGAP004563; -.
DR   VectorBase; AGAP004563-RA; AGAP004563-PA; AGAP004563.
DR   CTD; 1274704; -.
DR   eggNOG; KOG3690; Eukaryota.
DR   eggNOG; ENOG410XPJ3; LUCA.
DR   HOGENOM; HOG000007838; -.
DR   InParanoid; Q7Q9W7; -.
DR   KO; K01283; -.
DR   OMA; VTMEQLF; -.
DR   OrthoDB; EOG091G06JU; -.
DR   PhylomeDB; Q7Q9W7; -.
DR   Proteomes; UP000007062; Chromosome 2R.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008241; F:peptidyl-dipeptidase activity; IEA:InterPro.
DR   CDD; cd06461; M2_ACE; 2.
DR   InterPro; IPR001548; Peptidase_M2.
DR   PANTHER; PTHR10514; PTHR10514; 2.
DR   Pfam; PF01401; Peptidase_M2; 2.
DR   PRINTS; PR00791; PEPDIPTASEA.
PE   3: Inferred from homology;
KW   Carboxypeptidase {ECO:0000256|RuleBase:RU361144};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007062};
KW   Glycoprotein {ECO:0000256|RuleBase:RU361144};
KW   Hydrolase {ECO:0000256|RuleBase:RU361144};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|RuleBase:RU361144};
KW   Metalloprotease {ECO:0000256|RuleBase:RU361144};
KW   Protease {ECO:0000256|RuleBase:RU361144};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007062};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|RuleBase:RU361144}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20   1225       Angiotensin-converting enzyme.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5011427052.
FT   TRANSMEM   1205   1224       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   1225 AA;  142803 MW;  45708A1A09DC5826 CRC64;
     MKVFVYLVFL CVWYGRTSQS LPQVVVHREA LTEEQMAATL EQYDQDVRVL CNRNAIANWN
     VATDTENEYL QEVQNNVSLE YAKFRNDYYE QHFKSANVED YRSEKIRKQL RLLKDLGTAA
     LPAEKLASLN RVLRKMDTAY QLAEVCPYEN QQCDAADSKW TLDPELEKVM AESDNYDELE
     YVWRRWREES GKKMRSDYKE YVALVNEAAR LNGYEDYGAL WRSKYDDPKL RETLERLWSE
     VEPLYDELHS YVRYRLFELY GDRMDKMNPM IPAHLLGNMW AQSWANMYDR LKPFSNASLV
     DVTAKMKELG FNATRMFEMS DEFYQSLGLP SSAMSYGAKA VIEKPPQKIV CHASAWDFCD
     GEDFRIKMCT NINMGDFITV HHEMGHIMYY ILYKDQPNLF RTGATPAFHE AVGDTIALSV
     ATPNHLRKVG LLDEYEDSQA DNVNALFEMA LERVAFLPFG YLIDMWRWDV FSGAVNESEW
     NAHWWKLREK YQKVYAPVTR SEEDFDPGAK YHIPASSQYI AYFLAHILEF QFYRALCIEA
     GQYDPSQTSG QPLHKCDFYR SKAAGDKLRD GLSLGYSEDW EDALEMLTGE REISGKALLE
     YFEPLYQFLK EENRKFKTAQ MPNIVERYSE QYSTACTKQV RAQYATQVDV GNPQLQQQLT
     DVLAENTQFV LENYNRYFAD VDPKDVSDPI VSRQLEFLTQ ISINKLPAQD LTKLQHALGR
     MQNIYSSATI CPYRDRKCSE GRLSLDPELY EIMAKSEDFE EMQYVWNEWR RVTGRNMKPD
     FKTYVDMMNR AAKLGGFQDM GELWRSSFEQ DDFVNGMKRL WGELKPFYDE LHKYVHRKLK
     AIYGERIKDD NIPAHLLGNM WAQSWLNVYE RTKPFENTVD LDITEALKAK NYTVRQLFEI
     ANDFYVGLGL PDNSMSYDTA RGAMIEKPTD GRVVTCHASA WDFCDREDFR IKMCTRMNME
     DFVTIHHEMG HINYYILYKD QPVTLRSGAN PGFHEAVGDT ISLSVATPKH FEKIGLLQGY
     NDTYEENINA LYQKALDRVA FLPFGLLIDM WRWEVFAGKV DYSRWNERWW ELREEYQKVS
     APVERDGDDF DPGAKYHIPY DSQYVSYFIA HILDLQLHKA LCTAANQYDP NDPAKPLHKC
     DIDGSRAAGD LLRAGLSLGR SVHWSEALKA MTGETELRSD ALLEYYKPLY EFLREENAKA
     GSARFVPVSI SLILIPCIVF LFRYY
//
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