ID Q7QEL8_ANOGA Unreviewed; 407 AA.
AC Q7QEL8;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 07-DEC-2004, sequence version 2.
DT 01-MAY-2013, entry version 78.
DE RecName: Full=Mannose-6-phosphate isomerase;
DE EC=5.3.1.8;
GN ORFNames=AGAP000053, AgaP_AGAP000053;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC Pterygota; Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea;
OC Culicidae; Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B.,
RA Lai Z., Kraft C.L., Abril J.F., Anthouard V., Arensburger P.,
RA Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V.,
RA Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S.,
RA Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M.,
RA Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I.,
RA Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z.,
RA Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R.,
RA Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E.,
RA Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F.,
RA Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R.,
RA Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C.,
RA Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V.,
RA Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D.,
RA Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H.,
RA Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A.,
RA Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F.,
RA Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S.,
RA Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C.,
RA Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
CC -!- CATALYTIC ACTIVITY: D-mannose 6-phosphate = D-fructose 6-
CC phosphate.
CC -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-
CC phosphate: step 1/2.
CC -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 1
CC family.
CC -!- CAUTION: The sequence shown here is derived from an
CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC preliminary data.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AAAB01008846; EAA06219.2; -; Genomic_DNA.
DR RefSeq; XP_311105.2; XM_311105.5.
DR ProteinModelPortal; Q7QEL8; -.
DR STRING; 7165.AGAP000053-PA; -.
DR STRING; Q7QEL8; -.
DR EnsemblMetazoa; AGAP000053-RA; AGAP000053-PA; AGAP000053.
DR GeneID; 1272223; -.
DR KEGG; aga:AgaP_AGAP000053; -.
DR VectorBase; AGAP000053; Anopheles gambiae.
DR eggNOG; COG1482; -.
DR HOGENOM; HOG000241277; -.
DR KO; K01809; -.
DR OMA; ACTPHAY; -.
DR OrthoDB; EOG4J6Q69; -.
DR PhylomeDB; Q7QEL8; -.
DR UniPathway; UPA00126; UER00423.
DR GO; GO:0004476; F:mannose-6-phosphate isomerase activity; IEA:EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.60.120.10; -; 3.
DR InterPro; IPR001250; Man6P_Isoase-1.
DR InterPro; IPR016305; Mannose-6-P_Isomerase.
DR InterPro; IPR018050; Pmannose_isomerase-type1_CS.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin.
DR PANTHER; PTHR10309; PTHR10309; 1.
DR Pfam; PF01238; PMI_typeI; 1.
DR PIRSF; PIRSF001480; Mannose-6-phosphate_isomerase; 1.
DR PRINTS; PR00714; MAN6PISMRASE.
DR SUPFAM; SSF51182; RmlC_like_cupin; 1.
DR TIGRFAMs; TIGR00218; manA; 1.
DR PROSITE; PS00965; PMI_I_1; 1.
DR PROSITE; PS00966; PMI_I_2; 1.
PE 3: Inferred from homology;
KW Complete proteome; Isomerase; Reference proteome; Zinc.
SQ SEQUENCE 407 AA; 44570 MW; B5265A55AF257945 CRC64;
MEIVGNVKCY EWGKLGLDSF VAKLAQANSD GLEVKPDCPY AELWMGDHVS GPATLKTDGK
GLDQAIRADP AGMIGSPTGQ QLPFLLKVLS IRKALSVQVH PDKTEAEKLH RQFPDIYKDP
NHKPELAIAL TDFQALCGFR PHEDIARSLQ ETVELQQLLG AEVLAKLEAR DPSAVREGYE
RLMHSTPEAI ERCIAAMASR MQSADSASEL RDLFLRLHAD FGCDVGVLSI YFLNYLRLQP
GQAIYLAANV PHAYLDGDCV ECMACSDNVV RAGLTPKFKD VDTLLRLVRY DCLPGASMLF
QPRLLQPERQ PHTRTFVPPV PDFAVAEIRL PAASAGGLEY SVTNPANGSI LLTVGGGGTL
VGEDREIRLS MGTIVFLPSS AGKEFLLKVD EAGEPFLAFQ AMRNYFE
//
