ID Q7SDQ3_NEUCR Unreviewed; 1024 AA.
AC Q7SDQ3;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 3.
DT 27-MAR-2024, entry version 121.
DE SubName: Full=C2H2 type zinc finger domain-containing protein {ECO:0000313|EMBL:EAA34907.3};
GN ORFNames=NCU02853 {ECO:0000313|EMBL:EAA34907.3};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA34907.3, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:EAA34907.3, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
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DR EMBL; CM002236; EAA34907.3; -; Genomic_DNA.
DR RefSeq; XP_964143.3; XM_959050.3.
DR AlphaFoldDB; Q7SDQ3; -.
DR EnsemblFungi; EAA34907; EAA34907; NCU02853.
DR GeneID; 3880292; -.
DR KEGG; ncr:NCU02853; -.
DR VEuPathDB; FungiDB:NCU02853; -.
DR HOGENOM; CLU_012538_0_0_1; -.
DR InParanoid; Q7SDQ3; -.
DR OrthoDB; 1361823at2759; -.
DR Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd12148; fungal_TF_MHR; 1.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 2.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR InterPro; IPR001138; Zn2Cys6_DnaBD.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR40626; MIP31509P; 1.
DR PANTHER; PTHR40626:SF3; TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00066; GAL4; 1.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR SUPFAM; SSF57701; Zn2/Cys6 DNA-binding domain; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 8..35
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 71..100
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000259|PROSITE:PS50048"
FT REGION 103..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 220..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 965..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 480..510
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 220..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 968..982
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1024 AA; 119184 MW; EF15DFA6A801FABB CRC64;
MSEAAPVHRC PVCYKTYKRR EHLQRHRASH TSERPHRCIL CSASFQRTDV LKRHIQTCDG
LPHGSSGRRR ACDRCVRQKK ACNSAQPCQN CSKRAVQCLY SSVGSSSTSQ DGEAGSTSAA
NSVESFSNTP STQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQP QQQQQQQQQT
QQYQHQQFLH QQPQQLHQQQ QQQQQEQQQQ QQRQQQRQQQ QQQQHQQQHQ QQHQQQHQQQ
HQQQHQQQHQ QQQHQPIYLQ QQHQYQHQQY HHHQQQQQQQ QHPQRPPHHQ FQPQQHQQQT
YQQHPHQQQH NQQQRHHHNV LHAQVTQPLT QIPQIAPVPV PQIPRNHQVP VPQILQQSHQ
SHQPHSAHQP HHVPFHHPGV AHFDDLDNLL QDAAGQFPML GHQDTHIPDW IEMELPMGTH
AMDTPEGNTT SRSTPSSETH RGYSFDFLYD FTSRTGLVDS FECGTHAQRR AVVDAFYASY
AEQQKHHQQL QQIQQQQQQQ QQHLKAQQQI QGQLEFHPMF PQLQHHMGQP PLSPASSSAV
SISATSNDYS YMPWTPWSSW LSNPIIIKLQ EIVVSIMNVV RHKPSNSTLG TLTWTPDKEQ
ECLQFFSPQR FAKFLELFWS CWHPNVNFMH RPSFDPTSAK PTLLAAMALT GASVSPDEQD
TKDAKVWFNC VEEMVFTDDD FCSDTEPGSP ADDDANPASA LHCKRKLQAL QASYIVCLYQ
NWEGSDASKR RIRRHRFNTV VSVARDIGIP MAKHLEYGRL LRHEFDWHEY VVREELIRTF
LWVFLLDTAF VIFNNLPHRM VIKEMRMHMA SPEAVFQAPT AEKCLEEIYQ WMPSSSPICN
TLLRDVLENV IGTTLDADTL QRLARLGPLN LFVVVSVFHY MIFQHQNLFG VEGQLVPIRN
GLDNWITIWE LWCDHWSSTP PHCMAASDNL TPANMWKRIG FIRCSAEYWL LGSLLTDRIA
RKTSGGVREN QGKGSSPDSY PDELTGSGKG KSNDPILIKY DQTSMRQVNE LISDFKKIQL
EEIE
//
