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Database: UniProt/TrEMBL
Entry: Q826H9_STRAW
LinkDB: Q826H9_STRAW
Original site: Q826H9_STRAW 
ID   Q826H9_STRAW            Unreviewed;       739 AA.
AC   Q826H9;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   07-JUN-2017, entry version 93.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:BAC74925.1};
GN   Name=icdA {ECO:0000313|EMBL:BAC74925.1};
GN   ORFNames=SAVERM_7214 {ECO:0000313|EMBL:BAC74925.1};
OS   Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 /
OS   NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=227882 {ECO:0000313|EMBL:BAC74925.1, ECO:0000313|Proteomes:UP000000428};
RN   [1] {ECO:0000313|EMBL:BAC74925.1, ECO:0000313|Proteomes:UP000000428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC   NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX   PubMed=11572948; DOI=10.1073/pnas.211433198;
RA   Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C.,
RA   Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T.,
RA   Kikuchi H., Shiba T., Sakaki Y., Hattori M.;
RT   "Genome sequence of an industrial microorganism Streptomyces
RT   avermitilis: deducing the ability of producing secondary
RT   metabolites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN   [2] {ECO:0000313|EMBL:BAC74925.1, ECO:0000313|Proteomes:UP000000428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC   NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX   PubMed=12692562; DOI=10.1038/nbt820;
RA   Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M., Omura S.;
RT   "Complete genome sequence and comparative analysis of the industrial
RT   microorganism Streptomyces avermitilis.";
RL   Nat. Biotechnol. 21:526-531(2003).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; BA000030; BAC74925.1; -; Genomic_DNA.
DR   RefSeq; WP_010988609.1; NZ_JZJK01000085.1.
DR   ProteinModelPortal; Q826H9; -.
DR   STRING; 227882.SAV_7214; -.
DR   EnsemblBacteria; BAC74925; BAC74925; SAVERM_7214.
DR   KEGG; sma:SAV_7214; -.
DR   eggNOG; ENOG4105E9K; Bacteria.
DR   eggNOG; COG2838; LUCA.
DR   HOGENOM; HOG000240860; -.
DR   KO; K00031; -.
DR   OMA; RDSGKMW; -.
DR   OrthoDB; POG091H0B3N; -.
DR   Proteomes; UP000000428; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000428};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000428}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  79490 MW;  A42E3448E700E234 CRC64;
     MTDSTIIYTH TDEAPALATY SFLPVVQAYA SQAGVAVETR DISLAGRIIA LFPEYLEDGR
     RIPDALAELG ELAKTPEANI IKLPNISASI PQLKAAVAEL QEQGYALPDY PDDPKTDEER
     DIRARYDKVK GSAVNPVLRE GNSDRRAPAS VKNYAKTHPH RMGAWTSESK TNVATMGVDD
     FRSTEKSAVI SEAGSLRIEL KGDDGSTTVL RESVPVLPGE VVDASVMHVT ALREFLTAQI
     ARAKAENVLF SVHLKATMMK VSDPIVFGHV VRAFFPKTFA QYGETLAAAG LTPNDGLGGI
     YKGLESLPEG AAIKASFDAE LAEGPELAMV DSDKGITNLH VPSDVIVDAS MPAMIRTSGH
     MWGPDGQEQD TLAVLPDSSY SGVYQVVIDD CRANGAFDPS TMGTVPNVGL MAQKAEEYGS
     HDKTFEIPTT GTVRLVDQAG NVVLEQTVGA GDIFRACQTK DAPIKDWVKL AVTRARATGD
     PAVFWLDETR AHDAVLIEKV KQYLPEHDTE GLDIRVLSPV EATKFSVERI RRGENTISVT
     GNVLRDYLTD LFPILELGTS AKMLSIVPLM AGGGLFETGA GGSAPKHVQQ LVRENYLRWD
     SLGEFLALAS SFEHLATTTG NARAQVLADT LDRATATFLN EDKSPTRRVG GIDNRGSHFF
     LALYWAQELA GQTDDADLAK AFGPVAETLG TNEQKIVDEL ISAQGKPADI GGYYQPDPEK
     AAAVMRPSAT FNEAIASLA
//
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