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Database: UniProt/TrEMBL
Entry: Q82EQ5_STRAW
LinkDB: Q82EQ5_STRAW
Original site: Q82EQ5_STRAW 
ID   Q82EQ5_STRAW            Unreviewed;       430 AA.
AC   Q82EQ5;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   22-JAN-2014, entry version 83.
DE   RecName: Full=Aspartokinase;
DE            EC=2.7.2.4;
GN   Name=lysC; OrderedLocusNames=SAV_4559;
OS   Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 /
OS   NCIMB 12804 / NRRL 8165 / MA-4680).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=227882;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 /
RC   MA-4680;
RX   PubMed=11572948; DOI=10.1073/pnas.211433198;
RA   Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C.,
RA   Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T.,
RA   Kikuchi H., Shiba T., Sakaki Y., Hattori M.;
RT   "Genome sequence of an industrial microorganism Streptomyces
RT   avermitilis: deducing the ability of producing secondary
RT   metabolites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 /
RC   MA-4680;
RX   PubMed=12692562; DOI=10.1038/nbt820;
RA   Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M., Omura S.;
RT   "Complete genome sequence and comparative analysis of the industrial
RT   microorganism Streptomyces avermitilis.";
RL   Nat. Biotechnol. 21:526-531(2003).
CC   -!- CATALYTIC ACTIVITY: ATP + L-aspartate = ADP + 4-phospho-L-
CC       aspartate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC       pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 1/3.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 1/5.
CC   -!- SIMILARITY: Belongs to the aspartokinase family.
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DR   EMBL; BA000030; BAC72271.1; -; Genomic_DNA.
DR   RefSeq; NP_825736.1; NC_003155.4.
DR   ProteinModelPortal; Q82EQ5; -.
DR   SMR; Q82EQ5; 261-425.
DR   STRING; 227882.SAV_4559; -.
DR   EnsemblBacteria; BAC72271; BAC72271; SAV_4559.
DR   GeneID; 1211011; -.
DR   KEGG; sma:SAV_4559; -.
DR   PATRIC; 23722979; VBIStrAve112782_4870.
DR   HOGENOM; HOG000293093; -.
DR   KO; K00928; -.
DR   OMA; INIMMIS; -.
DR   OrthoDB; EOG6NSGHC; -.
DR   ProtClustDB; PRK06635; -.
DR   BioCyc; SAVE227882:GJU1-4611-MONOMER; -.
DR   UniPathway; UPA00034; UER00015.
DR   UniPathway; UPA00050; UER00461.
DR   UniPathway; UPA00051; UER00462.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004072; F:aspartate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.1160.10; -; 1.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR005260; Asp_kin_monofn.
DR   InterPro; IPR001341; Asp_kinase_dom.
DR   InterPro; IPR018042; Aspartate_kinase_CS.
DR   InterPro; IPR027795; GATS-like_ACT_dom.
DR   Pfam; PF00696; AA_kinase; 1.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF13840; ACT_7; 1.
DR   PIRSF; PIRSF000726; Asp_kin; 1.
DR   SUPFAM; SSF53633; SSF53633; 1.
DR   TIGRFAMs; TIGR00656; asp_kin_monofn; 1.
DR   TIGRFAMs; TIGR00657; asp_kinases; 1.
DR   PROSITE; PS51671; ACT; 2.
DR   PROSITE; PS00324; ASPARTOKINASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Kinase; Transferase.
SQ   SEQUENCE   430 AA;  45385 MW;  E8D01134859C3A2B CRC64;
     MGLVVQKYGG SSVADAEGIK RVAKRIVEAK KNGHQVVVVV SAMGDTTDEL IDLAEQVSPM
     PSGREFDMLL TAGERISMAL LAMAIKNLGH SAQSFTGSQA GVITDSVHNK ARIIDVTPGR
     IRTALDEGNI AIVAGFQGVS QDKKDITTLG RGGSDTTAVA LAAALDAEVC EIYTDVDGVF
     TADPRVVKKA KKIDWIAFED MLELAASGSK VLLHRCVEYA RRYNIPIHVR SSFSGLQGTW
     VSNTPLVQKA QQQGEQKVEQ AIISGVAHDT SEAKVTVVGV PDKPGEAASI FRAIADAEVN
     IDMVVQNVSA ASTGLTDISF TLPKTEGRKA IDALEKAKSV IGFDSLRYDD QIGKISLVGA
     GMKTNPGVTA GFFEALSDAG VNIELISTSE IRISVVTRAD DVPEAVRAVH TAFGLDSDSD
     EAVVYGGTGR
//
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