ID Q82EQ5_STRAW Unreviewed; 430 AA.
AC Q82EQ5;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 01-MAY-2013, entry version 78.
DE RecName: Full=Aspartokinase;
DE EC=2.7.2.4;
GN Name=lysC; OrderedLocusNames=SAV_4559;
OS Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 /
OS NCIMB 12804 / NRRL 8165 / MA-4680).
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Streptomycineae; Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=227882;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 /
RC MA-4680;
RX PubMed=11572948; DOI=10.1073/pnas.211433198;
RA Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C.,
RA Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T.,
RA Kikuchi H., Shiba T., Sakaki Y., Hattori M.;
RT "Genome sequence of an industrial microorganism Streptomyces
RT avermitilis: deducing the ability of producing secondary
RT metabolites.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 /
RC MA-4680;
RX PubMed=12692562; DOI=10.1038/nbt820;
RA Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA Sakaki Y., Hattori M., Omura S.;
RT "Complete genome sequence and comparative analysis of the industrial
RT microorganism Streptomyces avermitilis.";
RL Nat. Biotechnol. 21:526-531(2003).
CC -!- CATALYTIC ACTIVITY: ATP + L-aspartate = ADP + 4-phospho-L-
CC aspartate.
CC -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC novo pathway; L-homoserine from L-aspartate: step 1/3.
CC -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC threonine from L-aspartate: step 1/5.
CC -!- SIMILARITY: Belongs to the aspartokinase family.
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DR EMBL; BA000030; BAC72271.1; -; Genomic_DNA.
DR RefSeq; NP_825736.1; NC_003155.4.
DR ProteinModelPortal; Q82EQ5; -.
DR SMR; Q82EQ5; 261-425.
DR STRING; 227882.SAV_4559; -.
DR EnsemblBacteria; BAC72271; BAC72271; SAV_4559.
DR GeneID; 1211011; -.
DR KEGG; sma:SAV_4559; -.
DR PATRIC; 23722979; VBIStrAve112782_4870.
DR HOGENOM; HOG000293093; -.
DR KO; K00928; -.
DR OMA; SVDMIIQ; -.
DR ProtClustDB; PRK06635; -.
DR BioCyc; SAVE227882:GJU1-4611-MONOMER; -.
DR UniPathway; UPA00034; UER00015.
DR UniPathway; UPA00050; UER00461.
DR UniPathway; UPA00051; UER00462.
DR GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR GO; GO:0004072; F:aspartate kinase activity; IEA:EC.
DR GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-UniPathway.
DR GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.1160.10; -; 1.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR InterPro; IPR005260; Asp_kin_monofn.
DR InterPro; IPR001341; Asp_kinase_dom.
DR InterPro; IPR018042; Aspartate_kinase_CS.
DR Pfam; PF00696; AA_kinase; 1.
DR Pfam; PF01842; ACT; 1.
DR PIRSF; PIRSF000726; Asp_kin; 1.
DR SUPFAM; SSF53633; Aa_kinase; 1.
DR TIGRFAMs; TIGR00656; asp_kin_monofn; 1.
DR TIGRFAMs; TIGR00657; asp_kinases; 1.
DR PROSITE; PS00324; ASPARTOKINASE; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Complete proteome; Kinase; Transferase.
SQ SEQUENCE 430 AA; 45385 MW; E8D01134859C3A2B CRC64;
MGLVVQKYGG SSVADAEGIK RVAKRIVEAK KNGHQVVVVV SAMGDTTDEL IDLAEQVSPM
PSGREFDMLL TAGERISMAL LAMAIKNLGH SAQSFTGSQA GVITDSVHNK ARIIDVTPGR
IRTALDEGNI AIVAGFQGVS QDKKDITTLG RGGSDTTAVA LAAALDAEVC EIYTDVDGVF
TADPRVVKKA KKIDWIAFED MLELAASGSK VLLHRCVEYA RRYNIPIHVR SSFSGLQGTW
VSNTPLVQKA QQQGEQKVEQ AIISGVAHDT SEAKVTVVGV PDKPGEAASI FRAIADAEVN
IDMVVQNVSA ASTGLTDISF TLPKTEGRKA IDALEKAKSV IGFDSLRYDD QIGKISLVGA
GMKTNPGVTA GFFEALSDAG VNIELISTSE IRISVVTRAD DVPEAVRAVH TAFGLDSDSD
EAVVYGGTGR
//
