ID Q898T6_CLOTE Unreviewed; 389 AA.
AC Q898T6;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 01-MAY-2013, entry version 87.
DE SubName: Full=NAD-dependent malic enzyme;
DE EC=1.1.1.38;
GN OrderedLocusNames=CTC_00356;
OS Clostridium tetani (strain Massachusetts / E88).
OC Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=212717;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Massachusetts / E88;
RX PubMed=12552129; DOI=10.1073/pnas.0335853100;
RA Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H.,
RA Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A.,
RA Gottschalk G.;
RT "The genome sequence of Clostridium tetani, the causative agent of
RT tetanus disease.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003).
CC -!- COFACTOR: Divalent metal cations. Prefers magnesium or manganese
CC (By similarity).
CC -!- SIMILARITY: Belongs to the malic enzymes family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AE015927; AAO34993.1; -; Genomic_DNA.
DR RefSeq; NP_781056.1; NC_004557.1.
DR ProteinModelPortal; Q898T6; -.
DR SMR; Q898T6; 2-382.
DR STRING; 212717.CTC00356; -.
DR EnsemblBacteria; AAO34993; AAO34993; CTC_00356.
DR GeneID; 1059931; -.
DR KEGG; ctc:CTC00356; -.
DR PATRIC; 19508534; VBICloTet101274_0323.
DR KO; K00027; -.
DR OMA; VKAREIN; -.
DR ProtClustDB; CLSK911955; -.
DR BioCyc; CTET212717:GJAM-313-MONOMER; -.
DR GO; GO:0016619; F:malate dehydrogenase (oxaloacetate-decarboxylating) activity; IEA:EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0006108; P:malate metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.10380; -; 1.
DR Gene3D; 3.40.50.720; -; 1.
DR InterPro; IPR015884; Malic_enzyme_CS.
DR InterPro; IPR012301; Malic_N.
DR InterPro; IPR012302; Malic_NAD-bd.
DR InterPro; IPR001891; Malic_OxRdtase.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR Pfam; PF00390; malic; 1.
DR Pfam; PF03949; Malic_M; 1.
DR PIRSF; PIRSF000106; ME; 1.
DR PRINTS; PR00072; MALOXRDTASE.
DR SMART; SM00919; Malic_M; 1.
DR PROSITE; PS00331; MALIC_ENZYMES; 1.
PE 3: Inferred from homology;
KW Complete proteome; Metal-binding; Oxidoreductase.
FT ACT_SITE 36 36 Proton donor (By similarity).
FT ACT_SITE 91 91 Proton acceptor (By similarity).
FT METAL 133 133 Divalent metal cation (By similarity).
FT METAL 134 134 Divalent metal cation (By similarity).
FT METAL 159 159 Divalent metal cation (By similarity).
SQ SEQUENCE 389 AA; 42268 MW; B89ECC08D413B72D CRC64;
MDVKEMALKL HSEKKGKLEV VGKISVKNRE DLALAYTPGV AEPCVHISKD KNKVYEYTTK
GNMVAVVTNG TAVLGLGNIG PEAALPVMEG KALLFKEFAN VDAFPICLDT EDPEEIIRTV
KLMAPGFGGI NLEDIKAPEC FYIEERLKKE LDIPVFHDDQ HGTAIVVLAG IYNALKIVDK
KLEEAKILIN GAGSAGIAIC KLLLNAGACN IVMCDINGSL VEGDENLNPA QKEIAKVTNK
EKEKGKLVDV IKDKDIFIGV SGPKILTKEM VSTMAKDSIV FAMANPEPEI LPDEAKAGGA
RVVATGRSDF PNQINNVLVF PGIFRGALDV KAREINEEMK IAAARGVANL IKEEDLNEEY
IIPDPFNKEV AESVSKEVRR IAKEMNICK
//
