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Database: UniProt/TrEMBL
Entry: Q8CWP8_STRR6
LinkDB: Q8CWP8_STRR6
Original site: Q8CWP8_STRR6 
ID   Q8CWP8_STRR6            Unreviewed;       697 AA.
AC   Q8CWP8;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   22-NOV-2017, entry version 101.
DE   SubName: Full=Sialidase B (Neuraminidase B) {ECO:0000313|EMBL:AAL00335.1};
DE            EC=3.2.1.18 {ECO:0000313|EMBL:AAL00335.1};
GN   Name=nanB {ECO:0000313|EMBL:AAL00335.1};
GN   OrderedLocusNames=spr1531 {ECO:0000313|EMBL:AAL00335.1};
OS   Streptococcus pneumoniae (strain ATCC BAA-255 / R6).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=171101 {ECO:0000313|EMBL:AAL00335.1, ECO:0000313|Proteomes:UP000000586};
RN   [1] {ECO:0000313|EMBL:AAL00335.1, ECO:0000313|Proteomes:UP000000586}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-255 / R6 {ECO:0000313|Proteomes:UP000000586};
RX   PubMed=11544234; DOI=10.1128/JB.183.19.5709-5717.2001;
RA   Hoskins J.A., Alborn W.Jr., Arnold J., Blaszczak L., Burgett S.,
RA   DeHoff B.S., Estrem S., Fritz L., Fu D.-J., Fuller W., Geringer C.,
RA   Gilmour R., Glass J.S., Khoja H., Kraft A., LaGace R., LeBlanc D.J.,
RA   Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., McAhren S.,
RA   McHenney M., McLeaster K., Mundy C., Nicas T.I., Norris F.H.,
RA   O'Gara M., Peery R., Robertson G.T., Rockey P., Sun P.-M.,
RA   Winkler M.E., Yang Y., Young-Bellido M., Zhao G., Zook C., Baltz R.H.,
RA   Jaskunas S.Richard., Rosteck P.R.Jr., Skatrud P.L., Glass J.I.;
RT   "Genome of the bacterium Streptococcus pneumoniae strain R6.";
RL   J. Bacteriol. 183:5709-5717(2001).
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DR   EMBL; AE007317; AAL00335.1; -; Genomic_DNA.
DR   PIR; B98063; B98063.
DR   RefSeq; NP_359124.1; NC_003098.1.
DR   RefSeq; WP_001042137.1; NC_003098.1.
DR   ProteinModelPortal; Q8CWP8; -.
DR   STRING; 171101.spr1531; -.
DR   CAZy; CBM40; Carbohydrate-Binding Module Family 40.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   EnsemblBacteria; AAL00335; AAL00335; spr1531.
DR   GeneID; 933504; -.
DR   KEGG; spr:spr1531; -.
DR   PATRIC; fig|171101.6.peg.1651; -.
DR   eggNOG; ENOG4108J4G; Bacteria.
DR   eggNOG; COG4409; LUCA.
DR   HOGENOM; HOG000285031; -.
DR   KO; K01186; -.
DR   OMA; IFLMADM; -.
DR   Proteomes; UP000000586; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IBA:GO_Central.
DR   GO; GO:0006689; P:ganglioside catabolic process; IBA:GO_Central.
DR   GO; GO:0009313; P:oligosaccharide catabolic process; IBA:GO_Central.
DR   InterPro; IPR002860; BNR_rpt.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR004124; Glyco_hydro_33_N.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; PTHR10628; 1.
DR   Pfam; PF02012; BNR; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   Pfam; PF02973; Sialidase; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   SUPFAM; SSF50939; SSF50939; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000586};
KW   Glycosidase {ECO:0000313|EMBL:AAL00335.1};
KW   Hydrolase {ECO:0000313|EMBL:AAL00335.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000586};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     29       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        30    697       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004304157.
FT   DOMAIN       42    227       Sialidase. {ECO:0000259|Pfam:PF02973}.
FT   DOMAIN      457    661       Sialidase. {ECO:0000259|Pfam:PF13088}.
SQ   SEQUENCE   697 AA;  77664 MW;  38766D2F6747AE53 CRC64;
     MNKRGLYSKL GISVVGISLL MGVPALIHAN ELNYGQLSIS PIFQGGSYQL NNKSIDISPL
     LLDKLSGDSQ TVVMKFKADK PNSLQALFGL SNSKAGFKNN YFSIFMRDSG EIGVEIRDAQ
     KGINYLFSRP ASLWGKHKGQ AVENTLVFVS DSKDKTYTMY VNGIEVFSET VDTFLPISNI
     NGIDKATLGA VNREGKEHYL AKGSIDEISL FNKAISDQEV STIPLSNPFQ LIFQSGDSTQ
     ANYFRIPTLY TLSSGRVLSS IDARYGGTHD SKSKINIATS YSDDNGKTWS EPIFAMKFND
     YEEQLVYWPR DNKLKNSQIS GSASFIDSSI VEDKKSGKTI LLADVMPAGI GNNNANKADS
     GFKEINGHYY LKLKKNGDND FRYTVRENGV VYDETTNKPT NYTINDKYEV LEGGKSLTVE
     QYSVDFDSGS LRERHNGKQV PMNVFYKDSL FKVTPTNYIA MTTSQNRGES WEQFKLLPPF
     LGEKHNGTYL CPGQGLALKS SNRLIFATYT SGELTYLISD DSGQTWKKSS ASIPFENATA
     EAQMVELRDG VIRTFFRTTT GKIAYMTSRD SGETWSEVSY IDGIQQTSYG TQVSAIKYSQ
     LIDGKEAVIL STPNSRSGRK GGQLVVGLVN KEDDSIDWKY HYDIDLPSYG YAYSAITELP
     NHHIGVLFEK YDSWSRNELH LSNVVQYIDL EINDLTK
//
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