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Database: UniProt/TrEMBL
Entry: Q8DJC8_THEEB
LinkDB: Q8DJC8_THEEB
Original site: Q8DJC8_THEEB 
ID   Q8DJC8_THEEB            Unreviewed;       426 AA.
AC   Q8DJC8;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   20-DEC-2017, entry version 99.
DE   RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE            EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN   OrderedLocusNames=tll1299 {ECO:0000313|EMBL:BAC08851.1};
OS   Thermosynechococcus elongatus (strain BP-1).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae;
OC   Thermosynechococcus.
OX   NCBI_TaxID=197221 {ECO:0000313|EMBL:BAC08851.1, ECO:0000313|Proteomes:UP000000440};
RN   [1] {ECO:0000313|EMBL:BAC08851.1, ECO:0000313|Proteomes:UP000000440}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BP-1 {ECO:0000313|EMBL:BAC08851.1,
RC   ECO:0000313|Proteomes:UP000000440};
RX   PubMed=12240834; DOI=10.1093/dnares/9.4.123;
RA   Nakamura Y., Kaneko T., Sato S., Ikeuchi M., Katoh H., Sasamoto S.,
RA   Watanabe A., Iriguchi M., Kawashima K., Kimura T., Kishida Y.,
RA   Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N.,
RA   Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S.;
RT   "Complete genome structure of the thermophilic cyanobacterium
RT   Thermosynechococcus elongatus BP-1.";
RL   DNA Res. 9:123-130(2002).
CC   -!- COFACTOR:
CC       Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC         Evidence={ECO:0000256|RuleBase:RU003423};
CC   -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003423}.
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DR   EMBL; BA000039; BAC08851.1; -; Genomic_DNA.
DR   RefSeq; NP_682089.1; NC_004113.1.
DR   RefSeq; WP_011057139.1; NC_004113.1.
DR   ProteinModelPortal; Q8DJC8; -.
DR   STRING; 197221.tll1299; -.
DR   EnsemblBacteria; BAC08851; BAC08851; BAC08851.
DR   GeneID; 1011099; -.
DR   KEGG; tel:tll1299; -.
DR   PATRIC; fig|197221.4.peg.1367; -.
DR   eggNOG; ENOG4107UKP; Bacteria.
DR   eggNOG; COG0508; LUCA.
DR   HOGENOM; HOG000281566; -.
DR   KO; K00627; -.
DR   OMA; TMEFESF; -.
DR   OrthoDB; POG091H04EL; -.
DR   BioCyc; TELO197221:G13HA-1321-MONOMER; -.
DR   Proteomes; UP000000440; Chromosome.
DR   GO; GO:0016746; F:transferase activity, transferring acyl groups; IEA:UniProtKB-KW.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   Gene3D; 4.10.320.10; -; 1.
DR   InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR   InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR036625; E3-bd_dom_sf.
DR   InterPro; IPR004167; PSBD.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   Pfam; PF00198; 2-oxoacid_dh; 1.
DR   Pfam; PF00364; Biotin_lipoyl; 1.
DR   Pfam; PF02817; E3_binding; 1.
DR   SUPFAM; SSF47005; SSF47005; 1.
DR   SUPFAM; SSF51230; SSF51230; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR   PROSITE; PS00189; LIPOYL; 1.
DR   PROSITE; PS51826; PSBD; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003423};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000440};
KW   Lipoyl {ECO:0000256|RuleBase:RU003423, ECO:0000256|SAAS:SAAS00100674};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000440};
KW   Transferase {ECO:0000256|RuleBase:RU003423,
KW   ECO:0000313|EMBL:BAC08851.1}.
FT   DOMAIN        2     77       Lipoyl-binding. {ECO:0000259|PROSITE:
FT                                PS50968}.
FT   DOMAIN      136    173       Peripheral subunit-binding (PSBD).
FT                                {ECO:0000259|PROSITE:PS51826}.
FT   COILED       76     96       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   426 AA;  44418 MW;  1E529DDF715EB4B1 CRC64;
     MIRELFMPAL SSTMTEGKIV SWLKSPGDKV TKGETVLIVE SDKADMDVES FYDGYLAVIT
     VPAGEVAPVG STIGLVAETE AEIAEAEAKA KSLGTATSSG PAPASTSTVA TSNGSGTAPV
     AAAPAASAAV PAGRVMASPR ARKLAKEHKI DLKTLKGTGP NGRITAADVE ALIGAPATPV
     PPVATSPAPI PTAPPATAAV VAKEDLVPLT TLQNAVVRNM VASLGIPDFH VAYTITTDAL
     DRLYQQIKSK GVTMTALLAK AIALTLQKHP IMNAYYTEQG IQYRRDINIA VAVAMPGGGL
     ITPVLKNADQ IDLYSLSRTW KDLVERARAK QLQPDEYSTG TFSLSNLGMF GVDFFDAILT
     PGQGAIMAVG ASRPTVVATE DGLLGVKRQM KVNITCDHRV IYGADAAAFL QDLAKLIETN
     PQALTL
//
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