ID   Q8FA10_LEPIN            Unreviewed;       758 AA.
AC   Q8FA10;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   01-MAY-2013, entry version 54.
DE   SubName: Full=Adenylate/guanylate cyclase;
GN   OrderedLocusNames=LA_0027;
OS   Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai
OS   (strain 56601).
OC   Bacteria; Spirochaetes; Spirochaetales; Leptospiraceae; Leptospira.
OX   NCBI_TaxID=189518;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=56601;
RX   PubMed=12712204; DOI=10.1038/nature01597;
RA   Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H.,
RA   Zhang Y.-X., Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F.,
RA   Jiang J.-X., Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H., Yin H.-F.,
RA   Zhang Y., Zhu G.-F., Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W.,
RA   Yao Z.-J., Shen Y., Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A.,
RA   Saint Girons I., Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z.,
RA   Xu J.-G., Zhao G.-P.;
RT   "Unique physiological and pathogenic features of Leptospira
RT   interrogans revealed by whole-genome sequencing.";
RL   Nature 422:888-893(2003).
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DR   EMBL; AE010300; AAN47226.1; -; Genomic_DNA.
DR   RefSeq; NP_710208.1; NC_004342.2.
DR   ProteinModelPortal; Q8FA10; -.
DR   STRING; 189518.LA0027; -.
DR   EnsemblBacteria; AAN47226; AAN47226; LA_0027.
DR   GeneID; 1149370; -.
DR   KEGG; lil:LA_0027; -.
DR   PATRIC; 22380893; VBILepInt91350_0031.
DR   HOGENOM; HOG000118029; -.
DR   KO; K01768; -.
DR   OMA; MSEIGIR; -.
DR   ProtClustDB; CLSK573299; -.
DR   BioCyc; LINT189518:GJBB-24-MONOMER; -.
DR   GO; GO:0016849; F:phosphorus-oxygen lyase activity; IEA:InterPro.
DR   GO; GO:0004673; F:protein histidine kinase activity; IEA:InterPro.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0070483; P:detection of hypoxia; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0046777; P:protein autophosphorylation; IEA:InterPro.
DR   Gene3D; 3.30.70.1230; -; 1.
DR   InterPro; IPR011623; 7TMR_DISM_rcpt_extracell_dom1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR027035; DosT.
DR   PANTHER; PTHR11347:SF2; PTHR11347:SF2; 1.
DR   Pfam; PF07695; 7TMR-DISM_7TM; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; A/G_cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Complete proteome; Reference proteome.
SQ   SEQUENCE   758 AA;  88485 MW;  043D568226F585C0 CRC64;
     MIRLIRTFAY ILVFWILCSC VSDSDRFQNL DLITQAEWTA SLGNHLKDRL EKSNVQKSFL
     KNKKEKLNIE TNSREKESKD FKNWKLITRF PVNFNFLFSI PKQSGFHDVT VKVEFSIHSD
     SIFLTFLKQP TAIYFPDLGE NWELYLNGIP IRKEKFLKQT DTGDLIPSVR RSLKSVILPI
     PSGVLKEGKN TILIYMIGES DFTHYIPNEH FGFYHSKGYK ILSLEQIYES TFEYWDLLLY
     GIYTIFGIYH IYFYFIRRKD LYYLYFGLFS FFSSVYFFSS SNLIFQKFVN PNPELDSSLF
     FRMQYSSLTL IFPSFYYFLK DYFSPKEKGS MIASFFVIFL IGLFFAFLTV PFSWVHIAFK
     ICQILAICFS VYILFFSIQT VRKKKQDARK ILVGICVCIV FSTWELYGSV FENAKYHSTF
     FKLVYLFFII SIASTLVLRY VQLYKDAQLL NKYLIDQKEA FYRFVPVDFI RIIDRESPIS
     ISVGDSKEKS MTVLTSCIRN FASLSKTVPL NQTITFLNSY LSEMEELVYK TTGFVDKYIG
     NEILALFGDY DERAAKENFN SADNAVESAI KMVNAIRSGK LVKNFLIPSF WNLEIGIGIN
     TGSVILGTVG SERRIDTTVI GDAVDLSSGL RSLTALYKSK ILVSHHTYLR LHRMSEIGIR
     MIDSVILKER DQAVDIYEVI ESDPESIKEF KLKTLELLSQ GILEYKSKRF DEAAKIFRQL
     YREEPKDFIS MIYLKRCKLY SSKPPDENWD GVFRFQTK
//