ID Q8I4E0_CAEEL Unreviewed; 445 AA.
AC Q8I4E0;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 24-JAN-2024, entry version 133.
DE SubName: Full=Glutamate decarboxylase {ECO:0000313|EMBL:CAD45605.1};
GN Name=unc-25 {ECO:0000313|EMBL:CAD45605.1,
GN ECO:0000313|WormBase:Y37D8A.23b};
GN ORFNames=CELE_Y37D8A.23 {ECO:0000313|EMBL:CAD45605.1}, Y37D8A.23
GN {ECO:0000313|WormBase:Y37D8A.23b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAD45605.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAD45605.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAD45605.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR602129-50, ECO:0000256|RuleBase:RU000382};
CC -!- SIMILARITY: Belongs to the group II decarboxylase family.
CC {ECO:0000256|RuleBase:RU000382}.
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DR EMBL; BX284603; CAD45605.1; -; Genomic_DNA.
DR RefSeq; NP_001022831.1; NM_001027660.2.
DR AlphaFoldDB; Q8I4E0; -.
DR SMR; Q8I4E0; -.
DR PeptideAtlas; Q8I4E0; -.
DR EnsemblMetazoa; Y37D8A.23b.1; Y37D8A.23b.1; WBGene00006762.
DR GeneID; 176713; -.
DR UCSC; Y37D8A.23a; c. elegans.
DR AGR; WB:WBGene00006762; -.
DR WormBase; Y37D8A.23b; CE31832; WBGene00006762; unc-25.
DR GeneTree; ENSGT00940000170473; -.
DR OrthoDB; 888358at2759; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00006762; Expressed in larva and 3 other cell types or tissues.
DR ExpressionAtlas; Q8I4E0; baseline and differential.
DR GO; GO:0030424; C:axon; IDA:WormBase.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0060077; C:inhibitory synapse; IDA:WormBase.
DR GO; GO:0043025; C:neuronal cell body; IDA:WormBase.
DR GO; GO:0008021; C:synaptic vesicle; IDA:WormBase.
DR GO; GO:0004351; F:glutamate decarboxylase activity; ISS:WormBase.
DR GO; GO:0030170; F:pyridoxal phosphate binding; ISS:WormBase.
DR GO; GO:0009449; P:gamma-aminobutyric acid biosynthetic process; ISS:WormBase.
DR GO; GO:0051932; P:synaptic transmission, GABAergic; IGI:WormBase.
DR CDD; cd06450; DOPA_deC_like; 1.
DR Gene3D; 3.90.1150.170; -; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR PANTHER; PTHR45677:SF10; GLUTAMATE DECARBOXYLASE; 1.
DR PANTHER; PTHR45677; GLUTAMATE DECARBOXYLASE-RELATED; 1.
DR Pfam; PF00282; Pyridoxal_deC; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 1: Evidence at protein level;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000382};
KW Proteomics identification {ECO:0007829|EPD:Q8I4E0,
KW ECO:0007829|PeptideAtlas:Q8I4E0};
KW Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR602129-50,
KW ECO:0000256|RuleBase:RU000382};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT MOD_RES 320
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR602129-50"
SQ SEQUENCE 445 AA; 50309 MW; 4FC0C3AFC4E12801 CRC64;
MSSAAADESD AVLENLIAKE ILPQTGNWEG TEEFLNRIVQ VLLKYIKDQN DRDQKILEFH
HPDKMQMLMD LSIPEKPESL LKLVKSCEDV LRLGVRTGHP RFFNQISCGL DLVSMAGEWL
TATANTNMFT YEIAPVFILM EKSVMARMWE AVGWDPEKAD GIFAPGGAIA NLYAMNAARH
QLWPRSKHLG MKDIPTLCCF TSEDSHYSIK SASAVLGIGA DYCFNIPTDK NGKMIPEALE
AKIIECKKEG LTPFFACCTA GSTVYGAFDP LERVANICER HKLWFHVDAA WGGGMLLSPE
HRYKLAGIER ANSVTWNPHK LMGALLQCSA CLFRQDGLLF QCNQMSADYL FQQDKPYDVS
FDTGDKAIQC GRHNDVFKLW LMWKSKGMEG YRQQINKLMD LANYFTRRIK ETEGFELIIE
NVSFARIPEH LFLVRAFKDS KLGAC
//
