ID Q8IKD7_PLAF7 Unreviewed; 2454 AA.
AC Q8IKD7;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 2.
DT 24-JAN-2024, entry version 111.
DE RecName: Full=PI3K/PI4K catalytic domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PF3D7_1470100 {ECO:0000313|EMBL:CZU00398.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CZU00398.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|EMBL:CZU00398.1, ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
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DR EMBL; LN999946; CZU00398.1; -; Genomic_DNA.
DR RefSeq; XP_001348842.2; XM_001348806.2.
DR AlphaFoldDB; Q8IKD7; -.
DR STRING; 36329.Q8IKD7; -.
DR PaxDb; 5833-PF14_0668; -.
DR EnsemblProtists; CZU00398; CZU00398; PF3D7_1470100.
DR GeneID; 812250; -.
DR KEGG; pfa:PF3D7_1470100; -.
DR VEuPathDB; PlasmoDB:PF3D7_1470100; -.
DR HOGENOM; CLU_232593_0_0_1; -.
DR InParanoid; Q8IKD7; -.
DR OMA; TSFSIFH; -.
DR OrthoDB; 240713at2759; -.
DR PhylomeDB; Q8IKD7; -.
DR Proteomes; UP000001450; Chromosome 14.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048487; F:beta-tubulin binding; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0007023; P:post-chaperonin tubulin folding pathway; IEA:InterPro.
DR GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR GO; GO:0007021; P:tubulin complex assembly; IEA:InterPro.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR033162; TBCD.
DR PANTHER; PTHR12658; BETA-TUBULIN COFACTOR D; 1.
DR PANTHER; PTHR12658:SF0; TUBULIN-SPECIFIC CHAPERONE D; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 292..310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 628..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2454 AA; 295114 MW; 206E6135BA705216 CRC64;
MESKKTFFRE NEQVKNRLES VMNIINKDDD KYILDNFNII LDNLYYLKSC LNSYREVKNV
LDPHLNLLVH SFLYFMKKSF KNVKYIISYY KKNLYEEEKK RNENDNISVE INKCNIAHID
EDSNNNNNNN NVKISYDTIK ICSEEQFHFG FLKNNLIHGN NNNSNTHQDT EKNVQCTIHI
NNMLNKENIK NHIGCSKDDY EYSACVNSKT NLERKYSDDE FLNMYIIIKE IYKYYNTLIS
VRGEKKIKSL FTCNSFYLYN IVDLLLLLKR EEEIFEYISN LVYNKTGENN SWVFSYILII
WLSFCLYIPF KLKDVDKYML NNIEEIYYYY IKKNEKSKEA CSILYSHFLR RQDVYECNIY
FHHFFLISKE IMMKLIYIDL EKAKSKEPKD EEFYIIKNKE LPSYCNNTKF SNIILHGILL
THKRVLKKVE KKILFNYKKF YNFFLIQNFK YLDFTETSKA LKILCLGYYA LLFLDKNEDY
KNITSTNVET NNNHSCNINI LEKSKEEKKK ESNIYKLTQK NSLSNTKFCY NNLDYEHMYK
DHPLFHKLPM YVNINDAFIE YKTAHETEHF HILGNKKEIN NNILEKNKVN TTSDNINLEN
DYSNTYHIEQ NKCEDNVILF DKKDSSTNNT TITKKDNSNN NNDNDNTNNN NDNDNSNNNN
DNGSNNDNSS NNNIYYRPSY KEQLEHIKIV GGKKFICESH IMEILNIFFF YFNDNNSYIR
WCLSKSFGNI MIYLNVDNIN TVINKFDDFT KYNDYNMLCT INYTLFHFLF NKNIISVDIL
NYLLKKIIHS LYSDKVKIYP SAFVLLYSLF KYNKYIKMNF KNNVTNINYF LFHLIFIKLI
IFSLFEDNIN VRKSSMSLLQ LYVGKFNFFY EIENKNRLDK NTMEIAEMYV NNNNNVCDND
LIVDTPMENN VHNHENKNIN SYFIDNSKGN LNNIIEHPMY ISSSKNNQEH FFDRMLDFIN
LFFSHSDIST YYENVRNMSN EFVDNSKISI PLIKYTINNY NINKNINNDN NENINNNNEN
INNDINENIN NCDNIFYKRN HRYMNQIKRD IFNKNIDLLR TCNFNELINL KKSIIIKTKM
VCNFFLYKYP IIYHLYSNKL FHENVNVRLL SSESLSNLCI LDCDYFIHVV LPFLIKKSYE
ENVLIKHGSI ICISKILLKL KKEINENLQN DIKNIIIYSE KKRIYKFKKG EILRHSLCLL
IQSICQCNYF LVKKNTCTFF KDILHNNLFH YNEIIQFEAS KIFYYMPIYL LSKQHTIEFI
YEVFFNIIKK KNNFLHLKGY FILLCFVNDT IIPYVCSELI QLFYYILKKN STYYKTKNKY
YIKHNKEDIQ NINVENTNDY NDIKKDVYFF KKINFETYPI DYNMKIFCLL SLFNVVNNLR
NIYISDFLKV YTKCTINFKG LIKSRGPKIN KKKKINNINI HEMDYFSNST NENNERENSQ
VNCSNKKASY LNGSGNNSSN GKELEYNLRS GSLYKNDNLN NNKVDEKELC FERDSVDKNY
NELTIPLDVS YHKKKRRKRN TSFYIRKDIN FIRKEISWDK VLEKNKKKNG DMHSDILEYK
LNINKITKIL ILYLQEYVYE NDIGDSHIFV REICLGLTIF LLTSYPLYFF KKRNKNVQNV
NNINDVNDVN NLSNVKNVVN AYKDRIKEKN DDTKIHKVDK CSCPLKLYHP NEKSSDKNKN
MCLSKNYFYE QFDSDNSYED EDEEYINDKN GTDDILKNEK EETYYIYIIY KIKKKYINIL
IQLLLKLLCE KNMRTHKMCL FLLNYLYNYS IFNTKEKIMD TFSFNNIFNK YCHDFSYELF
LKKKIDDNIR KSKMNIYNYL NTYSDNICNV FENIIVHTCD YYQPLYLKED KEQNIEFEEE
DLEKEKIYNN TPCSCVYEEE ITSLFLNKNY KYNLIKTIFN KINNFIYLYN YALKYASFSI
FHKNKYMSTR KGVIKGYSEK DNIESCDNMN NIKDNLDDAH NDPCEFNKLD GNKKSDDLCF
DLIFDNIHIN NDFIDEMNVS ENEDKISMEE EGLIKDVHFL LDKGKKNISV IKCLEYNEIY
LYKHIFYLLF LNKYNYYIIN GFFNSLCYYS SHSEYSNYEY TNLITKGKEK SIEFLFLEFL
ERYKNIYTFG YIRDDILFLY IRYYKKYYVN YDYSIVNNII YQYNDNKNKK MKKLLYPYND
SYEKLIDNEG NENLQMDGYM ENDLEKYDNF GCCYNYEENY FSLFNYNMHD INLKEIISLE
KTCREFNYSY NIFNNYNIYF DGNIILFYNN VESNNMDKSL QKKKRIKENK KIKREQHEKI
ELLPYVNICL IKILYYLNNF NLVQLEIFLK SVNSFIKSSI MNNFAAYSFL YFFLISLDKY
NSFALIKTIS EVIINIFMCL SIHNNIKRLA MFLILQLLVH RYPKIREFTN EYFYANINFI
SPSEFKHYLF KSYEDLESIM SILINTQFSL MLKKENCHIK LAVEEISTLL NIPY
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